scholarly journals Serum visfatin level is associated with complexity of coronary artery disease in patients with stable angina pectoris

2019 ◽  
Vol 13 ◽  
pp. 175394471988044
Author(s):  
Hakan Duman ◽  
Ali Gökhan Özyıldız ◽  
İlkay Bahçeci ◽  
Handan Duman ◽  
Abdulkadir Uslu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Angina Pectoris ◽  
Stable Angina ◽  
Multivariate Logistic Regression Analysis ◽  
Syntax Score ◽  
Stable Angina Pectoris ◽  
Artery Disease ◽  
Visfatin Level ◽  
Group 1

Background: Visfatin is an adipokine that plays a role in the inflammatory process of atherosclerosis. This study aimed to investigate whether adipokine is associated with the extent of stable coronary artery disease (CAD). Methods: The study population included 110 patients who underwent elective coronary angiography (CAG) due to stable angina pectoris. The severity of CAD was assessed by the ‘Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery (SYNTAX)’ score. We evaluated patients in two groups: group 1 with a SYNTAX score <22 (low) and group 2 with a SYNTAX score ⩾22 (intermediate to high). Results: Serum visfatin (8.6 ± 4.2 ng/ml versus 13.4 ± 5.2 ng/ml, p < 0.001) and serum C-reactive protein (CRP) levels [0.46 (0.25–0.77) mg/dl versus 0.71 (0.32–1.10) mg/dl, p < 0.001] were lower in group 1. A positive significant correlation was found between serum visfatin level and SYNTAX score ( r = 0.559, p < 0.001). In a multivariate logistic regression analysis, visfatin [odds ratio (OR) 1.22, 95% confidence interval (CI) 1.10–1.36; p < 0.001], CRP (OR 6.22, 95% CI 1.70–22.7; p = 0.006), and diabetes mellitus (OR 3.83, 95% CI 1.10–13.2; p = 0.034) were found to be independent predictors of SYNTAX score. Conclusions: Serum visfatin level was positively correlated with CAD severity in patients with high SYNTAX score. Serum visfatin level can be a useful biomarker for predicting high SYNTAX scores in patients with angina pectoris undergoing CAG.

scholarly journals Plasma MicroRNA-126-5p is Associated with the Complexity and Severity of Coronary Artery Disease in Patients with Stable Angina Pectoris

2016 ◽  
Vol 39 (3) ◽  
pp. 837-846 ◽  
Author(s):  
Hai-yu Li ◽  
Xin Zhao ◽  
Yu-Zhou Liu ◽  
Zhe Meng ◽  
Dan Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Angina Pectoris ◽  
Stable Angina ◽  
Syntax Score ◽  
Stable Angina Pectoris ◽  
Vessel Disease ◽  
Potential Biomarker ◽  
Artery Disease

Background: Coronary artery disease (CAD) is a major problem worldwide. As an endothelium-enriched microRNA (miRNA), miR-126 has been reported to serve as a potential biomarker of acute myocardial infarction. However, the relationship between miR-126 and the severity of CAD remains unknown. This study was designed to test whether circulating miR-126 levels are associated with the severity of CAD. Methods: The present study enrolled 40 patients who had risk factors for CAD without angiographically significant CAD, and 110 patients presenting with stable angina pectoris, who were validated left main coronary artery disease (LMCA) and/or multi-vessel disease by coronary angiography. The expression levels of plasma miR-126-5p from all enrolled subjects were estimated by quantitative real-time polymerase chain reaction (qRT-PCR). Then, the relationships between plasma miR-126-5p levels, number of diseased vessels and the corresponding Synergy between PCI with Taxus and Cardiac surgery (SYNTAX) score were analyzed. Results: The expression of circulating miR-126-5p was affected by some CAD risk factors including aging, dyslipidemia and DM. Furthermore, plasma miR-126-5p levels were significantly down-regulated in CAD patients with multi-vessel disease, higher SYNTAX score, rather than isolated LMCA and low SYNTAX score. Conclusion: Circulating miR-126-5p has emerged as a potential biomarker for complexity and severity of CAD in patients with stable angina pectoris.

scholarly journals Changes in blood rheology in patients with stable angina pectoris as a result of coronary artery disease.

Circulation ◽  
1987 ◽  
Vol 76 (1) ◽  
pp. 15-20 ◽  
Author(s):  
C Rainer ◽  
D T Kawanishi ◽  
P A Chandraratna ◽  
R M Bauersachs ◽  
C L Reid ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Angina Pectoris ◽  
Stable Angina ◽  
Blood Rheology ◽  
Stable Angina Pectoris ◽  
Artery Disease

Relationship between mild renal dysfunction and coronary artery disease in young patients with stable angina pectoris

2020 ◽  
Author(s):  
Mustafa Duran ◽  
Deniz Elcik ◽  
Mehmet T Inanc ◽  
Mikail Yarlıoglues ◽  
Ibrahim E Celik ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Angina Pectoris ◽  
Renal Dysfunction ◽  
Stable Angina ◽  
Control Group ◽  
Stable Angina Pectoris ◽  
Number Of Patients ◽  
Study Results ◽  
Artery Disease

Aim: We investigated the relationship between mild renal dysfunction (MRD) and the presence of coronary artery disease (CAD) in people under 60. Materials & methods: A total of 634 (317 patients with vessel stenosis ≥50% and 317 with normal angiography) individuals diagnosed with stable angina pectoris and estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m2 were included in the present study. Results: The mean eGFR was lower (95.3 ± 23.7 vs 109.7 ± 22.3, respectively, p = 0.002) and the number of patients with MRD was higher in patients with CAD (137, 43.2%) than in the control group (52, 16.4%, p < 0.001). The multivariate analysis showed that lower eGFR is an independent risk factor for presence of CAD in people under 60 with stable angina pectoris. Conclusion: According to our retrospective study, the risk of developing CAD appears to be slightly increased in individuals under 60 with MRD.

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