scholarly journals Establishment of cervical dynamic and static imbalance models and preliminary study on the mechanism of cervical degeneration in rats

2019 ◽  
Vol 26 (2) ◽  
pp. 107-116
Author(s):  
Haibo Li ◽  
Jianjian Yin ◽  
Yongjing Huang ◽  
Nanwei Xu ◽  
Liang Chen ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Inflammatory Cytokines ◽  
Test Group ◽  
Cervical Disc ◽  
Control Group ◽  
Sprague Dawley ◽  
Intervertebral Disc Space ◽  
Disc Space ◽  
X Ray ◽  
Post Operation

This study aimed to observe dynamically the changes of x-ray, histomorphology appearance and serum inflammatory cytokines of cervical degenerative disease in rat models and to discuss the mechanism of cervical degeneration. Sixty Sprague Dawley rats were randomised into test ( n = 45) and control ( n = 15) groups, which were randomly subdivided into three groups corresponding to 1, 3 and 6 mo post operation. At the corresponding postoperative stage, cervical x-ray films were acquired, and intervertebral disc space and intervertebral foramen size were measured. Some serum inflammatory cytokines from all rats were quantitatively determined. Then, the morphological change in cervical intervertebral disc specimens stained with hematoxylin and eosin was observed. The results were analysed and compared among groups. Compared to the control group, the cervical x-ray and histomorphology appearance of rats in the test group showed varying degrees of degeneration. Furthermore, the serum IL-1β, TNF-α and IL-10 in the test group increased significantly at the corresponding postoperative stage ( P < 0.05, P < 0.01 and P < 0.001, respectively) compared to the control group. This model of cervical disc degeneration can accelerate imaging and histological degeneration, but it may be accompanied by changes in serum inflammatory cytokines levels.

Intervertebral disc space cyst simulating a recurrent herniated nucleus pulposus

1988 ◽  
Vol 69 (1) ◽  
pp. 137-139 ◽  
Author(s):  
Jordan C. Grabel ◽  
Raphael Davis ◽  
Rosario Zappulla
Keyword(s):  
Intervertebral Disc ◽  
Preoperative Diagnosis ◽  
Relevant Literature ◽  
Radicular Pain ◽  
Lumbar Region ◽  
Intervertebral Disc Space ◽  
Disc Space ◽  
Content Type ◽  
Herniated Nucleus Pulposus ◽  
Fine Print

✓ The case presented is of a patient with an intervertebral disc space cyst producing recurrent radicular pain following microdiscectomy in the lumbar region. Difficulties with the preoperative diagnosis of this and other recurrent radicular syndromes are discussed, and a review of the relevant literature is presented.

scholarly journals NADPH Oxidase Inhibitor Apocynin Attenuates PCB153-Induced Thyroid Injury in Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Ablikim Abliz ◽  
Chen Chen ◽  
Wenhong Deng ◽  
Weixing Wang ◽  
Rongze Sun
Keyword(s):  
Thyroid Hormone ◽  
Nadph Oxidase ◽  
Inflammatory Cytokines ◽  
Thyroid Dysfunction ◽  
Thyroid Tissue ◽  
Oxidase Inhibitor ◽  
Control Group ◽  
Ros Generation ◽  
Sprague Dawley ◽  
Serum Thyroid Hormone

PCBs, widespread endocrine disruptors, cause the disturbance of thyroid hormone (TH) homeostasis in humans and animals. However, the exact mechanism of thyroid dysfunction caused by PCBs is still unknown. In order to clarify the hypotheses that NADPH oxidase (NOX) and subsequent NF-κB pathway may play roles in thyroid dysfunction, sixty Sprague-Dawley rats were randomly divided into four groups: control group, PCB153 treated (PCB) group, received apocynin with PCB153 treatment (APO + PCB) group, and drug control (APO) group. Serum thyroid hormone levels were evaluated. The morphological change of thyroid tissue was analyzed under the light and transmission electron microscopy. NOX2, 8-OHdG, and NF-κB expression in the thyroid tissue was evaluated by immune-histochemical staining. Oxidative stress and inflammatory cytokines were detected. The following results were reduced after apocynin treatment: (1) serum thyroid hormone, (2) thyroid pathological injuries, (3) thyroid MDA, (4) thyroid ultrastructural change, (5) serum inflammatory cytokines, and (6) thyroid expression of NOX2, 8-OHdG, and NF-κB. These results suggested that NOX inhibition attenuates thyroid dysfunction induced by PCB in rats, presumably because of its role in preventing ROS generation and inhibiting the activation of NF-κB pathway. Our findings may provide new therapeutic targets for PCBs induced thyroid dysfunction.

Radiographic Morphometry of Lumbar Intervertebral Disc Space in Normal Korean

2007 ◽  
Vol 14 (3) ◽  
pp. 129 ◽  
Author(s):  
Eun-Su Moon ◽  
Nam-Hyun Kim ◽  
Jin-Oh Park ◽  
Si-Young Park ◽  
Ho-Joong Kim ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Intervertebral Disc Space ◽  
Disc Space ◽  
Lumbar Intervertebral Disc ◽  
Radiographic Morphometry

THE HARTSHILL HORSESHOE: THE TREATMENT OF CHRONIC PAIN PATIENTS WITH DISCOGENIC PAIN IN THE ABSENCE OF NEURAL COMPRESSION A PROSPECTIVE 2½- TO 3-YEAR REVIEW

2000 ◽  
Vol 04 (03) ◽  
pp. 209-220 ◽  
Author(s):  
W. Peckett ◽  
P. Hardcastle ◽  
J. Sheppherd ◽  
C. Sridhar
Keyword(s):  
Intervertebral Disc ◽  
Bone Graft ◽  
Spinal Fusion ◽  
Central Area ◽  
Disc Height ◽  
Intervertebral Disc Space ◽  
Disc Space ◽  
Discogenic Pain ◽  
Radiological Results ◽  
Intervertebral Disc Height

Interbody fusion is a well-recognized technique to achieve spinal fusion. The advantage of using tricortical blocks as opposed to the dowel technique is that intervertebral disc height can be restored. Both techniques can be performed either by the anterior or posterior approach. The traditional tricortical block technique has advantages over using dowels as it is a more stable construct and can restore intervertebral disc height. However, autologous bone graft has an unpredictable behavior causing potential problems of disc space collapse, forward displacement of the graft and donor bone graft site morbidity. The Hartshill horseshoe was developed to overcome these autograft problems. It is an implant that is placed within the periphery of the intervertebral disc space where the vertebral end plate is strongest to resist compression forces. It has holes that allow screw fixation of the implant to bone to provide immediate stability and a central area for bone graft where the vertebral body is most vascular to allow incorporation of such a graft. Previous reports on the Hartshill horseshoe have used autograft (single tricortical graft). This prospective study reports the clinical and radiological results of 19 patients who underwent this procedure using xenograft 2½ to 3 years postoperative. The radiological results do not show any evidence of loosening of the screws or implant nor evidence of intervertebral disc space subsidence. It was not possible to assess the exact incidence of spinal fusion.

Outcome and prognostic factors in nonambulatory Hansen Type I intervertebral disc extrusions: 308 cases

2006 ◽  
Vol 19 (01) ◽  
pp. 29-34 ◽  
Author(s):  
D. A. Allen ◽  
E. R. Schertel ◽  
M. D. Barnhart ◽  
E. R. Wilson ◽  
J. A. Lineberger ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Intervertebral Disc ◽  
Motor Neuron ◽  
Lower Motor Neuron ◽  
Decompressive Surgery ◽  
Type I ◽  
Lumbar Region ◽  
Intervertebral Disc Space ◽  
Disc Space ◽  
Favourable Prognosis

SummaryThoracolumbar intervertebral disc disease is the most common cause of caudal paresis in dogs (1). Whilst the pathogenesis of the extrusion has been widely studied, treatment protocols and prognostic factors relating to outcome remain controversial. Recent studies have examined a multitude of factors relating to time to regain ambulation after decompressive surgery. Most intervertebral disc herniations occur in the thoracolumbar region, causing upper motor neuron signs in the rear limbs, which are thought to have a more favourable prognosis compared to the lower motor neuron signs created by herniation of an intervertebral disc in the caudal lumbar region. Due to the potential disruption of the lumbar intumescence, lower motor neuron signs have been reported as having a less favourable prognosis. The purpose of this study was to evaluate the intervertebral disc space as a prognostic factor relating to ambulatory outcome and time to ambulation after decompressive surgery. Hansen Type I intervertebral disc extrusions were studied in 308 non-ambulatory dogs. Preoperative and postoperative neurological status, corticosteroid use, signalment, intervertebral disc space, postoperative physical rehabilitation, previous hemilaminectomy surgery, disc fenestration, return to ambulation, and time to ambulation were reviewed.

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