scholarly journals The amazing innate immune response to influenza A virus infection

2013 ◽  
Vol 21 (1) ◽  
pp. 73-98 ◽  
Author(s):  
Shweta Tripathi ◽  
Mitchell R White ◽  
Kevan L Hartshorn
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Innate Immune Response ◽  
Influenza A ◽  
Innate Immune ◽  
Influenza A Virus Infection

scholarly journals Model of influenza A virus infection: Dynamics of viral antagonism and innate immune response

2014 ◽  
Vol 351 ◽  
pp. 47-57 ◽  
Author(s):  
M. Fribourg ◽  
B. Hartmann ◽  
M. Schmolke ◽  
N. Marjanovic ◽  
R.A. Albrecht ◽  
...  
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Innate Immune Response ◽  
Influenza A ◽  
Innate Immune ◽  
Infection Dynamics ◽  
Influenza A Virus Infection

scholarly journals The adaptor protein FHL2 enhances the cellular innate immune response to influenza A virus infection

2012 ◽  
Vol 14 (7) ◽  
pp. 1135-1147 ◽  
Author(s):  
Carolin Nordhoff ◽  
Andrea Hillesheim ◽  
Beate M. Walter ◽  
Emanuel Haasbach ◽  
Oliver Planz ◽  
...  
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Innate Immune Response ◽  
Influenza A ◽  
Adaptor Protein ◽  
Innate Immune ◽  
Influenza A Virus Infection

scholarly journals NMP4 regulates the innate immune response to influenza A virus infection

2020 ◽  
Vol 14 (1) ◽  
pp. 209-218
Author(s):  
Shuangshuang Yang ◽  
Michele Adaway ◽  
Jianguang Du ◽  
Shengping Huang ◽  
Jie Sun ◽  
...  
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Innate Immune Response ◽  
Influenza A ◽  
Innate Immune ◽  
Influenza A Virus Infection

scholarly journals Pulmonary influenza A virus infection leads to suppression of the innate immune response to dermal injury

2018 ◽  
Vol 14 (8) ◽  
pp. e1007212 ◽  
Author(s):  
Meredith J. Crane ◽  
Yun Xu ◽  
William L. Henry ◽  
Sean P. Gillis ◽  
Jorge E. Albina ◽  
...  
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Innate Immune Response ◽  
Influenza A ◽  
Innate Immune ◽  
Influenza A Virus Infection

scholarly journals Complexes of Oligoribonucleotides with d-Mannitol Modulate the Innate Immune Response to Influenza A Virus H1N1 (A/FM/1/47) In Vivo

2018 ◽  
Vol 11 (3) ◽  
pp. 73 ◽  
Author(s):  
Nataliia Melnichuk ◽  
Vladimir Kashuba ◽  
Svitlana Rybalko ◽  
Zenoviy Tkachuk
Keyword(s):  
Immune Response ◽  
Influenza Virus ◽  
Virus Infection ◽  
Signaling Pathways ◽  
Influenza A Virus ◽  
Innate Immune Response ◽  
Influenza A ◽  
Inflammatory Responses ◽  
Influenza Virus Infection ◽  
Innate Immune

Rapid replication of the influenza A virus and lung tissue damage caused by exaggerated pro-inflammatory host immune responses lead to numerous deaths. Therefore, novel therapeutic agents that have anti-influenza activities and attenuate excessive pro-inflammatory responses that are induced by an influenza virus infection are needed. Oligoribonucleotides-d-mannitol (ORNs-d-M) complexes possess both antiviral and anti-inflammatory activities. The current research was aimed at studying the ORNs-d-M effects on expression of innate immune genes in mice lungs during an influenza virus infection. Expression of genes was determined by RT-qPCR and Western blot assays. In the present studies, we found that the ORNs-d-M reduced the influenza-induced up-expression of Toll-like receptors (TLRs) (tlr3, tlr7, tlr8), nuclear factor NF-kB (nfkbia, nfnb1), cytokines (ifnε, ifnk, ifna2, ifnb1, ifnγ, il6, il1b, il12a, tnf), chemokines (ccl3, ccl4, сcl5, cxcl9, cxcl10, cxcl11), interferon-stimulated genes (ISGs) (oas1a, oas2, oas3, mx1), and pro-oxidation (nos2, xdh) genes. The ORNs-d-M inhibited the mRNA overexpression of tlr3, tlr7, and tlr8 induced by the influenza virus, which suggests that they impair the upregulation of NF-kB, cytokines, chemokines, ISGs, and pro-oxidation genes induced by the influenza virus by inhibiting activation of the TLR-3, TLR-7, and TLR-8 signaling pathways. By impairing activation of the TLR-3, TLR-7, and TLR-8 signaling pathways, the ORNs-d-M can modulate the innate immune response to an influenza virus infection.

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