Innate immune pathways in afferent lymph following vaccination with poly(I:C)-containing liposomes

2013 ◽  
Vol 20 (5) ◽  
pp. 501-510 ◽  
Author(s):  
Melissa L Burke ◽  
Michael de Veer ◽  
Jill Pleasance ◽  
Melanie Neeland ◽  
Martin Elhay ◽  
...  
Keyword(s):  
Innate Immune ◽  
Poly I:C ◽  
Immune Pathways ◽  
Afferent Lymph

scholarly journals Prolonged activation of innate immune pathways by a polyvalent STING agonist

2021 ◽  
Author(s):  
Suxin Li ◽  
Min Luo ◽  
Zhaohui Wang ◽  
Qiang Feng ◽  
Jonathan Wilhelm ◽  
...  
Keyword(s):  
Innate Immune ◽  
Immune Pathways

Interaction Between Adaptive and Innate Immune Pathways in the Pathogenesis of Atopic Asthma

CHEST Journal ◽  
2011 ◽  
Vol 139 (5) ◽  
pp. 1165-1171 ◽  
Author(s):  
Patrick G. Holt ◽  
Peter D. Sly
Keyword(s):  
Innate Immune ◽  
Atopic Asthma ◽  
Immune Pathways

scholarly journals Targeting the Complement Cascade in the Pathophysiology of COVID-19 Disease

2021 ◽  
Vol 10 (10) ◽  
pp. 2188
Author(s):  
Nicole Ng ◽  
Charles A. Powell
Keyword(s):  
Clinical Trials ◽  
Endothelial Dysfunction ◽  
Severe Acute Respiratory Syndrome ◽  
Disease Progression ◽  
Organ Dysfunction ◽  
Innate Immune ◽  
Complement Cascade ◽  
Significant Morbidity ◽  
Immune Pathways ◽  
Complement Pathways

Severe coronavirus disease 2019 causes multi-organ dysfunction with significant morbidity and mortality. Mounting evidence implicates maladaptive over-activation of innate immune pathways such as the complement cascade as well as endothelial dysfunction as significant contributors to disease progression. We review the complement pathways, the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on these pathways, and promising therapeutic targets in clinical trials.

scholarly journals An In Vitro Assessment of Immunostimulatory Responses to Ten Model Innate Immune Response Modulating Impurities (IIRMIs) and Peptide Drug Product, Teriparatide

Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7461
Author(s):  
Claire K. Holley ◽  
Edward Cedrone ◽  
Duncan Donohue ◽  
Barry W. Neun ◽  
Daniela Verthelyi ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Cytokine Secretion ◽  
Poly I:C ◽  
In Vitro Assays ◽  
Innate Immune Responses ◽  
Vitro Assay

Understanding, predicting, and minimizing the immunogenicity of peptide-based therapeutics are of paramount importance for ensuring the safety and efficacy of these products. The so-called anti-drug antibodies (ADA) may have various clinical consequences, including but not limited to the alteration in the product’s distribution, biological activity, and clearance profiles. The immunogenicity of biotherapeutics can be influenced by immunostimulation triggered by the presence of innate immune response modulating impurities (IIRMIs) inadvertently introduced during the manufacturing process. Herein, we evaluate the applicability of several in vitro assays (i.e., complement activation, leukocyte proliferation, and cytokine secretion) for the screening of innate immune responses induced by ten common IIRMIs (Bacillus subtilis flagellin, FSL-1, zymosan, ODN2006, poly(I:C) HMW, poly(I:C) LMW, CLO75, MDP, ODN2216, and Escherichia coli O111:B4 LPS), and a model biotherapeutic Forteo™ (teriparatide). Our study identifies cytokine secretion from healthy human donor peripheral blood mononuclear cells (PBMC) as a sensitive method for the in vitro monitoring of innate immune responses to individual IIRMIs and teriparatide (TP). We identify signature cytokines, evaluate both broad and narrow multiplex cytokine panels, and discuss how the assay logistics influence the performance of this in vitro assay.

scholarly journals Distinct Roles of Hemocytes at Different Stages of Infection by Dengue and Zika Viruses in Aedes aegypti Mosquitoes

2021 ◽  
Vol 12 ◽  
Author(s):  
Thiago H. J. F. Leite ◽  
Álvaro G. A. Ferreira ◽  
Jean-Luc Imler ◽  
João T. Marques
Keyword(s):  
Aedes Aegypti ◽  
Cellular Responses ◽  
Innate Immune ◽  
Mosquito Vector ◽  
Phagocytic Function ◽  
Systemic Dissemination ◽  
Latex Beads ◽  
Medical Importance ◽  
Immune Pathways

Aedes aegypti mosquitoes are vectors for arboviruses of medical importance such as dengue (DENV) and Zika (ZIKV) viruses. Different innate immune pathways contribute to the control of arboviruses in the mosquito vector including RNA interference, Toll and Jak-STAT pathways. However, the role of cellular responses mediated by circulating macrophage-like cells known as hemocytes remains unclear. Here we show that hemocytes are recruited to the midgut of Ae. aegypti mosquitoes in response to DENV or ZIKV. Blockade of the phagocytic function of hemocytes using latex beads induced increased accumulation of hemocytes in the midgut and a reduction in virus infection levels in this organ. In contrast, inhibition of phagocytosis by hemocytes led to increased systemic dissemination and replication of DENV and ZIKV. Hence, our work reveals a dual role for hemocytes in Ae. aegypti mosquitoes, whereby phagocytosis is not required to control viral infection in the midgut but is essential to restrict systemic dissemination. Further understanding of the mechanism behind this duality could help the design of vector-based strategies to prevent transmission of arboviruses.

scholarly journals Association of Symptoms and Severity of Rift Valley Fever with Genetic Polymorphisms in Human Innate Immune Pathways

2015 ◽  
Vol 9 (3) ◽  
pp. e0003584 ◽  
Author(s):  
Amy G. Hise ◽  
Zachary Traylor ◽  
Noémi B. Hall ◽  
Laura J. Sutherland ◽  
Saidi Dahir ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Innate Immune ◽  
Valley Fever ◽  
Immune Pathways

Identification of circular RNAs and their altered expression under poly(I:C) challenge in key antiviral immune pathways in amphioxus

2019 ◽  
Vol 86 ◽  
pp. 1053-1057 ◽  
Author(s):  
Qi-Lin Zhang ◽  
Xin-Yu Ji ◽  
Hong-Wei Li ◽  
Jun Guo ◽  
Feng Wang ◽  
...  
Keyword(s):  
Poly I:C ◽  
Circular Rnas ◽  
Altered Expression ◽  
Immune Pathways
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