Regulation of colon cancer cell proliferation and migration by MD-2 activity

2010 ◽  
Vol 17 (4) ◽  
pp. 414-422 ◽  
Author(s):  
Virginie Grondin ◽  
Philippe Seksik ◽  
Sylvie Dumont ◽  
Ginette Thomas ◽  
Germain Trugnan ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Colon Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Abril Sánchez-Botet ◽  
Laura Gasa ◽  
Eva Quandt ◽  
Sara Hernández-Ortega ◽  
Javier Jiménez ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Colon Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration

Citrate synthase desuccinylation by SIRT5 promotes colon cancer cell proliferation and migration

2020 ◽  
Vol 401 (9) ◽  
pp. 1031-1039
Author(s):  
Mengmeng Ren ◽  
Xin Yang ◽  
Juntao Bie ◽  
Zhe Wang ◽  
Minghui Liu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Proliferation ◽  
Enzymatic Activity ◽  
Cancer Cell ◽  
Citrate Synthase ◽  
Colon Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration

AbstractCitrate synthase (CS), the rate-limiting enzyme in the tricarboxylic acid (TCA) cycle catalyzes the first step of the cycle, namely, the condensation of oxaloacetate and acetyl-CoA to produce citrate. The expression and enzymatic activity of CS are altered in cancers, but posttranslational modification (PTM) of CS and its regulation in tumorigenesis remain largely obscure. SIRT5 belongs to the nicotinamide adenine dinucleotide (NAD)+-dependent deacetylase sirtuin family and plays vital roles in multiple biological processes via modulating various substrates. Here, we show that SIRT5 interacts with CS and that SIRT5 desuccinylates CS at the evolutionarily conserved residues K393 and K395. Moreover, hypersuccinylation of CS at K393 and K395 dramatically reduces its enzymatic activity and suppresses colon cancer cell proliferation and migration. These results provide experimental evidence in support of a potential therapeutic approach for colon cancer.

Sign in / Sign up

Export Citation Format

Share Document