scholarly journals Managing acute central nervous system infections in the UK adult intensive care unit in the wake of UK encephalitis guidelines

2015 ◽  
Vol 16 (4) ◽  
pp. 330-338
Author(s):  
DJ Stoeter ◽  
BD Michael ◽  
T Solomon ◽  
L Poole
Keyword(s):  
Intensive Care Unit ◽  
Central Nervous System ◽  
Nervous System ◽  
Intensive Care ◽  
Central Nervous System Infections ◽  
Adult Intensive Care Unit ◽  
The Uk

scholarly journals Central nervous system infection in the intensive care unit: Development and validation of a multi-parameter diagnostic prediction tool to identify suspected patients

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0260551
Author(s):  
Hugo Boechat Andrade ◽  
Ivan Rocha Ferreira da Silva ◽  
Justin Lee Sim ◽  
José Henrique Mello-Neto ◽  
Pedro Henrique Nascimento Theodoro ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Central Nervous System ◽  
Nervous System ◽  
Intensive Care ◽  
Validation Cohort ◽  
Diagnostic Model ◽  
High Morbidity ◽  
Operating Characteristics ◽  
Central Nervous System Infections ◽  
Receiver Operating

Background Central nervous system infections (CNSI) are diseases with high morbidity and mortality, and their diagnosis in the intensive care environment can be challenging. Objective: To develop and validate a diagnostic model to quickly screen intensive care patients with suspected CNSI using readily available clinical data. Methods Derivation cohort: 783 patients admitted to an infectious diseases intensive care unit (ICU) in Oswaldo Cruz Foundation, Rio de Janeiro RJ, Brazil, for any reason, between 01/01/2012 and 06/30/2019, with a prevalence of 97 (12.4%) CNSI cases. Validation cohort 1: 163 patients prospectively collected, between 07/01/2019 and 07/01/2020, from the same ICU, with 15 (9.2%) CNSI cases. Validation cohort 2: 7,270 patients with 88 CNSI (1.21%) admitted to a neuro ICU in Chicago, IL, USA between 01/01/2014 and 06/30/2019. Prediction model: Multivariate logistic regression analysis was performed to construct the model, and Receiver Operating Characteristic (ROC) curve analysis was used for model validation. Eight predictors—age <56 years old, cerebrospinal fluid white blood cell count >2 cells/mm3, fever (≥38°C/100.4°F), focal neurologic deficit, Glasgow Coma Scale <14 points, AIDS/HIV, and seizure—were included in the development diagnostic model (P<0.05). Results The pool data’s model had an Area Under the Receiver Operating Characteristics (AUC) curve of 0.892 (95% confidence interval 0.864–0.921, P<0.0001). Conclusions A promising and straightforward screening tool for central nervous system infections, with few and readily available clinical variables, was developed and had good accuracy, with internal and external validity.

Sign in / Sign up

Export Citation Format

Share Document