The DAMA Trial: A Diet and Physical Activity Intervention Trial to Reduce Mammographic Breast Density in Postmenopausal Women in Tuscany, Italy. Study Protocol and Baseline Characteristics

2014 ◽  
Vol 100 (4) ◽  
pp. 377-385 ◽  
Author(s):  
Giovanna Masala ◽  
Melania Assedi ◽  
Saverio Caini ◽  
Ilaria Ermini ◽  
Daniela Occhini ◽  
...  
Keyword(s):  
Physical Activity ◽  
Postmenopausal Women ◽  
Breast Density ◽  
Study Protocol ◽  
Physical Activity Intervention ◽  
Mammographic Breast Density ◽  
Intervention Trial ◽  
Diet And Physical Activity ◽  
Baseline Characteristics

scholarly journals Effects of a 1-Year Physical Activity Intervention on Markers of Hemostasis among Breast Cancer Survivors: A Randomized Controlled Trial

TH Open ◽  
2021 ◽  
Vol 05 (01) ◽  
pp. e14-e23
Author(s):  
Siv Kjølsrud Bøhn ◽  
Inger Thune ◽  
Vidar Gordon Flote ◽  
Hanne Frydenberg ◽  
Gro Falkenér Bertheussen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Postmenopausal Women ◽  
Cancer Patients ◽  
Physical Activity Intervention ◽  
Intervention Group ◽  
Factor Vii ◽  
Breast Cancer Patients ◽  
Hemostatic Factors

Abstract Introduction Physical activity may reduce the development of breast cancer. Whereas hypercoagulability has been linked to adverse outcomes in breast cancer patients, the effects of physical activity on their hemostatic factors are unknown. The study aimed to assess whether long-term (1 year) physical activity can affect hemostatic factors in breast cancer patients. Methods Fifty-five women (35–75 years) with invasive breast cancer stage I/II were randomized to a physical activity intervention (n = 29) lasting 1 year or to a control group (n = 26), and analyzed as intention to treat. Fibrinogen, factor VII antigen, tissue factor pathway inhibitor, and von Willebrand factor (VWF) antigen as well as prothrombin fragment 1 + 2, the endogenous thrombin potential and D-dimer, were measured in plasma before intervention (baseline), and then after 6 and 12 months. Results Maximal oxygen uptake (measure of cardiorespiratory fitness) decreased the first 6 months among the controls, but remained stable in the intervention group. We found no significant differences between the two study groups regarding any of the hemostatic factors, except a significantly higher increase in factor VII antigen in the intervention group. The effect of the intervention on VWF was, however, significantly affected by menopausal stage, and a significant effect of the intervention was found on VWF among postmenopausal women, even after adjustment for dietary intake. Conclusion Long-term physical activity had no effect on the majority of the hemostatic factors measured, but led to increased plasma concentrations of factor VII antigen and prevented an increase in VWF concentration after breast cancer treatment in postmenopausal women. The clinical impact of these findings for risk of vascular thrombosis warrants further studies.

Health-related lifestyle and dropout from a web-based physical activity intervention trial in older adults: A latent profile analysis.

2021 ◽  
Vol 40 (8) ◽  
pp. 481-490
Author(s):  
Tiara Ratz ◽  
Claudia Voelcker-Rehage ◽  
Claudia R. Pischke ◽  
Saskia Muellmann ◽  
Manuela Peters ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Latent Profile Analysis ◽  
Physical Activity Intervention ◽  
Profile Analysis ◽  
Intervention Trial ◽  
Web Based ◽  
Health Related ◽  
Latent Profile
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