Novel alginate, chitosan, and psyllium composite fiber for wound-care applications

2016 ◽  
Vol 47 (1) ◽  
pp. 20-37 ◽  
Author(s):  
Rashid Masood ◽  
Tanveer Hussain ◽  
Mohsen Miraftab ◽  
Azeem Ullah ◽  
Zulfiqar Ali Raza ◽  
...  
Keyword(s):  
Tensile Strength ◽  
Sodium Alginate ◽  
Wound Care ◽  
Antibacterial Properties ◽  
Coagulation Bath ◽  
Composite Fibers ◽  
Absorption Properties ◽  
Swelling Properties ◽  
Liquid Absorption ◽  
Dope Solution

Alginate/psyllium and alginate/chitosan fibers have great potential for wound-care applications. However, alginate/psyllium fibers have poor tensile strength and alginate/chitosan fibers comparatively have low liquid absorption properties. The main aim was to develop a tri-component fiber with comparatively better tensile strength and liquid absorption properties using three different natural polysaccharides. Alginate, chitosan, and psyllium composite fibers were made by using two different coagulation bath compositions. In method A, psyllium-containing sodium alginate dope solution was extruded into a bath containing CaCl2 and subsequently passed through hydrolyzed chitosan bath, whereas in method B: psyllium-containing sodium alginate dope solution was directly extruded into hydrolyzed chitosan and subsequently passed through CaCl2 bath. The produced fibers were rinsed using 25–100% acetone solutions and dried in air. Tensile, antibacterial, swelling, and absorption properties of these fibers were measured. The study showed that homogeneous fibers can be extruded by using both methods. The fibers produced showed good antibacterial, absorption, and swelling properties. Antibacterial activity of the controlled and composite fibers was more or less the same. However, tensile properties of fibers produced by method A and method B were less than the control alginate–chitosan fibers. The composite fibers produced by method A showed better absorption of saline and solution A than control fiber and composite fibers produced by method B. Therefore, method A is recommended for producing the psyllium-containing alginate chitosan fibers for wound-dressing applications. The fibers produced by this method showed comparable tensile and antibacterial properties, superior absorbency, and swelling properties.

Silver-containing polysaccharide-based tricomponent antibacterial fibres for wound care applications

2021 ◽  
Vol 30 (1) ◽  
pp. 81-88
Author(s):  
Rashid Masood ◽  
M. Anam Khubaib ◽  
Tanveer Hussain ◽  
Zulfiqar Ali Raza
Keyword(s):  
Infection Control ◽  
Calcium Chloride ◽  
Wound Care ◽  
Antibacterial Properties ◽  
Coagulation Bath ◽  
Silver Carbonate ◽  
Gelling Properties ◽  
Liquid Absorption ◽  
Dope Solution ◽  
Complex Wounds

Objective: Polysaccharide-based biomaterials are extensively used in wound care healing due to their unique liquid absorption, gelling properties and biocompatibility properties. They play an important role in controlling infections of highly exuding hard-to-heal wounds. The main objective of this study was to develop silver-containing polysaccharide-based tricomponent antibacterial fibres for use in these complex wounds. Method: The fibres were developed by coating silver-containing alginate and psyllium fibres with hydrolysed chitosan. Dope solution containing alginate, psyllium and silver carbonate was extruded into a coagulation bath containing calcium chloride and hydrolysed chitosan. The developed fibres were tested for liquid absorption, swelling and antibacterial properties against a control fibre (of alginate and psyllium). Results: The developed fibres showed comparatively better liquid absorption, gelling and antibacterial properties than the control fibres. Conclusion: The study concluded that developed fibres could be a preferred choice for application on hard-to-heal wounds with high levels of exudate, to support infection control and faster healing.

Preparation and Characterization of Alginate/Polyvinyl Alcohol Composite Fibers Containing Copper Ions

2013 ◽  
Vol 652-654 ◽  
pp. 1562-1565 ◽  
Author(s):  
Jing Guo ◽  
Qian He Chen ◽  
Yu Yan Zhang ◽  
Yu Mei Gong ◽  
Hong Zhang
Keyword(s):  
Tensile Strength ◽  
Polyvinyl Alcohol ◽  
Copper Ions ◽  
Fiber Surface ◽  
Coagulation Bath ◽  
Wet Spinning ◽  
Composite Fibers ◽  
Pseudoplastic Fluid ◽  
Cu Ions

Alginate/polyvinyl alcohol (PVA) composite fibers containing copper ions were prepared by wet spinning. The spinning solution and manufacturing process were researched. The composite fibers were characterized by Tensile Strength Tester, SEM and TGA. This report shows that the spinning solution is a typical kind of pseudoplastic fluid. Adding boric acid to coagulation bath and putting Cu ions into composite fibers can improve the strength. The structure of composite fibers with Cu ions is denser and there are grooves on the fiber surface. In addition, the thermal property of composite fibers is steady.

Preparation of Chitosan-Based Fiber Reticulated Medical Dressing and Its Application in Wound Care

2020 ◽  
Vol 12 (6) ◽  
pp. 921-931
Author(s):  
Peiying Han ◽  
Jie Ma ◽  
Min Lin ◽  
Xiaoyan Cai ◽  
Fang Fang
Keyword(s):  
Wound Healing ◽  
Wound Care ◽  
Antibacterial Properties ◽  
Biological Properties ◽  
Wound Area ◽  
Cell Compatibility ◽  
Wound Recovery ◽  
Liquid Absorption ◽  
Healing Of Wounds ◽  
Chitosan Fiber

With the continuous development of medical dressings, patients start to focus on how to take care of wounds caused by different reasons. Therefore, there is a need for medical dressings that can stop the bleeding and promote the healing of wounds with excellent biological properties. This study produced seven different dressing samples by combining chitosan fiber and hydroentanglement technique. The different dressings were characterized and analyzed for biological properties. At the same time, 60 New Zealand rabbits were selected for wound care experiments. Respectively, the wounds were constructed and were treated with sample 1 and sample 3, which were selected as experimental materials from the prepared dressing samples. Besides, the polyacrylate (SAP) and common gauze were taken as the control materials. Then, different dressings were used to cover the wounds of rabbits. Three days later, the dressings were changed every few days to observe the wounds. At the same time, the wound area and wound healing scores of the sample 1 group, sample 3 group, and SAP group were counted at 7 days, 14 days and 21 days after the operations. During the experiment, the chitosan fiber-based fiber web dressing showed excellent hygroscopicity and rigidity. For the comparison of biological properties, different samples all had excellent cell compatibility and antibacterial properties. Meanwhile, the antibacterial properties of sample 1 and sample 3 were all above 90%. For the wound care experiment, the adsorbent rate of sample 1 dressing was the fastest in the first 8 min, reaching 70% of the maximum liquid absorption. For the comparison of the wound recovery area and wound healing scores, compared with SAP and common gauze, the medical dressings based on composite chitosan fiber-hydroentanglement technique had better wound recovery performance. This has proved that the medical dressings proposed in this study have better wound care performances.

Tensile and Liquid Absorption Properties of Polyester-based Composites as Alternative Marble Materials

2021 ◽  
Vol 19 (12) ◽  
pp. 55-68
Author(s):  
Lamees Khalaf ◽  
Israa. Ghazi
Keyword(s):  
Tensile Strength ◽  
Composite Materials ◽  
Modulus Of Elasticity ◽  
Filler Content ◽  
Absorption Properties ◽  
Volume Fractions ◽  
Liquid Absorption ◽  
Absorption Percentage ◽  
Marble Industry ◽  
Strength And Toughness

Three polyester-based composite materials were prepared with different volume fractions of three types of fillers (i.e. cement, gypsum and limestone) with the aim of improving the tensile and liquid absorption properties of the former for the synthetic marble industry. The tensile strength, modulus of elasticity, toughness, ductility and liquid absorption percentage of the composites were characterized. Results revealed an increase in the modulus of elasticity, tensile strength and toughness of all prepared composites, as well as a decrease in their ductility, with increasing filler amount. The liquid absorption values of all composites increased with increasing filler content. The composites were able to absorb water extensively but absorbed benzene, kerosene and gasoil minimally.

scholarly journals Formulation and Optimization of Sodium Alginate Polymer Film as a Buccal Mucoadhesive Drug Delivery System Containing Cetirizine Dihydrochloride

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 619
Author(s):  
Krisztián Pamlényi ◽  
Katalin Kristó ◽  
Orsolya Jójárt-Laczkovich ◽  
Géza Regdon
Keyword(s):  
Drug Delivery ◽  
Tensile Strength ◽  
Sodium Alginate ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polymer Films ◽  
Hydroxypropyl Methylcellulose ◽  
Chemical Properties ◽  
Active Pharmaceutical Ingredient ◽  
Swallowing Problems

Currently, pharmaceutical companies are working on innovative methods, processes and products. Oral mucoadhesive systems, such as tablets, gels, and polymer films, are among these possible products. Oral mucoadhesive systems possess many advantages, including the possibility to be applied in swallowing problems. The present study focused on formulating buccal mucoadhesive polymer films and investigating the physical and physical–chemical properties of films. Sodium alginate (SA) and hydroxypropyl methylcellulose (HPMC) were used as film-forming agents, glycerol (GLY) was added as a plasticizer, and cetirizine dihydrochloride (CTZ) was used as an active pharmaceutical ingredient (API). The polymer films were prepared at room temperature with the solvent casting method by mixed two-level and three-level factorial designs. The thickness, tensile strength (hardness), mucoadhesivity, surface free energy (SFE), FTIR, and Raman spectra, as well as the dissolution of the prepared films, were investigated. The investigations showed that GLY can reduce the mucoadhesivity of films, and CTZ can increase the tensile strength of films. The distribution of CTZ proved to be homogeneous in the films. The API could dissolve completely from all the films. We can conclude that polymer films with 1% and 3% GLY concentrations are appropriate to be formulated for application on the buccal mucosa as a drug delivery system.

scholarly journals Green Synthesis and Incorporation of Sericin Silver Nanoclusters into Electrospun Ultrafine Cellulose Acetate Fibers for Anti-Bacterial Applications

Polymers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1411
Author(s):  
Mujahid Mehdi ◽  
Huihui Qiu ◽  
Bing Dai ◽  
Raja Fahad Qureshi ◽  
Sadam Hussain ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Green Synthesis ◽  
Cellulose Acetate ◽  
Antibacterial Properties ◽  
Vital Role ◽  
Silver Nanoclusters ◽  
Composite Fibers ◽  
E Coli ◽  
Antibacterial Performance ◽  
Field Emission Electron Microscopy

Fiber based antibacterial materials have gained an enormous attraction for the researchers in these days. In this study, a novel Sericin Encapsulated Silver Nanoclusters (sericin-AgNCs) were synthesized through single pot and green synthesis route. Subsequently these sericin-AgNCs were incorporated into ultrafine electrospun cellulose acetate (CA) fibers for assessing the antibacterial performance. The physicochemical properties of sericin-AgNCs/CA composite fibers were investigated by transmission electron microscopy (TEM), field emission electron microscopy (FE-SEM), Fourier transform infrared spectroscopy (FTIR) and wide X-ray diffraction (XRD). The antibacterial properties of sericin-AgNCs/CA composite fibers against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) were systematically evaluated. The results showed that sericin-AgNCs incorporated in ultrafine CA fibers have played a vital role for antibacterial activity. An amount of 0.17 mg/mL sericin-AgNCs to CA fibers showed more than 90% results and elevated upto >99.9% with 1.7 mg/mL of sericin-AgNCs against E. coli. The study indicated that sericin-AgNCs/CA composite confirms an enhanced antibacterial efficiency, which could be used as a promising antibacterial product.

Preparation and properties of wet-spun microcomposite filaments from cellulose nanocrystals and alginate using a microfluidic device

BioResources ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. 5780-5793
Author(s):  
Ji-Soo Park ◽  
Chan-Woo Park ◽  
Song-Yi Han ◽  
Eun-Ah Lee ◽  
Azelia Wulan Cindradewi ◽  
...  
Keyword(s):  
Tensile Properties ◽  
Sodium Alginate ◽  
Calcium Chloride ◽  
Microfluidic Device ◽  
Cellulose Nanocrystals ◽  
Average Diameter ◽  
Coagulation Bath ◽  
Al Content ◽  
Orientation Index ◽  
Cacl2 Solution

Cellulose nanocrystals (CNCs) were wet-spun in a coagulation bath for the fabrication of microfilaments, and the effect of sodium alginate (AL) addition on the wet-spinnability and properties of the microcomposite filament was investigated. The CNC suspension exhibited excellent wet-spinnability in calcium chloride (CaCl2) solution, and the addition of AL in CNC suspension resulted in the enhancement of the wet-spinnability of CNCs. As the AL content increased from 3% to 10%, the average diameter of the microcomposite filament decreased, and its tensile properties deteriorated. The increased spinning rate caused an increase in the orientation index of CNCs, resulting in an improvement in the tensile properties of the microcomposite filament.

scholarly journals FORMULATION OF AN ANTI-WRINKLE HYDROGEL FACE MASK CONTAINING ETHANOL EXTRACT OF NONI FRUIT (MORINDA CITRIFOLIA L) FOR USE AS A NUTRACOSMECEUTICAL PRODUCT

2017 ◽  
Vol 9 ◽  
pp. 74 ◽  
Author(s):  
Silvia Surini ◽  
Annisa Auliyya
Keyword(s):  
Tensile Strength ◽  
Sodium Alginate ◽  
Ursolic Acid ◽  
Xanthan Gum ◽  
Physical Stability ◽  
Ethanol Extract ◽  
Face Mask ◽  
Skin Care ◽  
Morinda Citrifolia ◽  
Water Holding

Objectives: Noni fruit (Morinda citrifolia L) containing ursolic acid and 3,3’ bisdemethylpinoresinol can be useful as an anti-wrinkle agent. Thehydrogel face mask is an alternative skin care product.Methods: In this study, 0.1% ethanol extract of noni fruit was formulated with a concentration of 4% sodium alginate and 0.5% xanthan gum to formthe hydrogel face mask. Physical stability of the hydrogel face mask was evaluated using organoleptic observation, consistency rates, swelling indexmeasurements, and mechanical strength.Results: The results showed that the hydrogel face mask has good water holding capacity, a tensile strength of 35.6524±0.8842 kgf/cm2, an elongationrate of 272.00±4.47%, and remains stable in color and odor for 12 weeks.Conclusions: This study revealed that the hydrogel face mask containing an ethanol extract of noni fruit is stable and has good physical characteristics;therefore, the hydrogel face mask is satisfactory for use as a nutracosmeceutical product.

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