scholarly journals Review Article: Mechanical ventilation in Duchenne patients with chronic respiratory insufficiency: clinical implications of 20 years published experience

2007 ◽  
Vol 4 (3) ◽  
pp. 167-177 ◽  
Author(s):  
M. Toussaint ◽  
M. Chatwin ◽  
P. Soudon
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Insufficiency ◽  
Review Article ◽  
Clinical Implications ◽  
Chronic Respiratory Insufficiency

scholarly journals Daytime mechanical ventilation in chronic respiratory insufficiency

1997 ◽  
Vol 10 (12) ◽  
pp. 2840-2846 ◽  
Author(s):  
B. Schönhofer ◽  
M. Geibel ◽  
M. Sonneborn ◽  
P. Haidl ◽  
D. Köhler
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Insufficiency ◽  
Chronic Respiratory Insufficiency

scholarly journals Psychometric properties of the Arabic-validated Severe Respiratory Insufficiency Questionnaire for the assessment of Health-Related Quality of Life in patients on home mechanical ventilation

2021 ◽  
Author(s):  
Salah Zeineldine ◽  
Marwan Alawieh ◽  
Mohamad Khatib ◽  
Rania Bzeih ◽  
Lilian Ghandour ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Insufficiency ◽  
Arabic Version ◽  
Health Related Quality ◽  
Home Mechanical Ventilation ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related ◽  
Chronic Respiratory Insufficiency

Abstract Background/objectives:Assessment of Health-Related Quality of Life (HRQL) in patients with chronic respiratory insufficiency requiring Home Mechanical Ventilation (HMV) needs a valid measurement tool. The Severe Respiratory Insufficiency (SRI) questionnaire, originally developed in German, has been translated into different languages and tested in different contexts, except in Arabic-speaking populations of Arab world. The objective of this study is to validate the Arabic version of the SRI questionnaire from its original German version.Methods:Forward/backward translations between German and Arabic were conducted. The final Arabic version was administered to 149 patients (53 males - 96 females, age 69.8±10 years) receiving HMV recruited from outpatient clinics. Patients were scheduled for a home visit during which the Arabic SRI and the 36-Item Short-Form Health Survey (SF-36) questionnaires were administered; data on sociodemographic and medical history were also collected. Dimensionality internal construct validity were assessed using exploratory factor analysis; internal consistency of the unidimensional scale and its subscales was also assessed using Cronbach’s alpha. External nomological validity was tested by assessing correlation between the SRI and SF-36 questionnaires.Results:PCA scree plot indicated the presence of only one factor that explained 63% of the total variability. The Cronbach alpha for the total scale was 0.897 (ranged between 0.73 and 0.87 for all subscales). Correlation between the SRI and SF-36 was highest amongst comparable subscales yielding r=0.81 and r=0.74 (P < 0.01).Conclusion & Recommendations:The Arabic SRI is a reliable and valid tool for assessing HRQL in patients with chronic respiratory insufficiency receiving home mechanical ventilation.

scholarly journals Validation of the Arabic Severe Respiratory Insufficiency Questionnaire

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Marwan F. Alawieh ◽  
Rania N. Bzeih ◽  
Mohamad F. El-Khatib ◽  
Abla M. Sibai ◽  
Lilian A. Ghandour ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Internal Consistency ◽  
Respiratory Insufficiency ◽  
Internal Consistency Reliability ◽  
Measurement Tool ◽  
Arabic Version ◽  
Home Mechanical Ventilation ◽  
Sf 36 ◽  
Chronic Respiratory Insufficiency ◽  
Arabic Speaking

Abstract Background/objectives Assessment of Health-Related Quality of Life (HRQL) in patients with chronic respiratory insufficiency requiring Home Mechanical Ventilation (HMV) requires a valid measurement tool. The Severe Respiratory Insufficiency (SRI) questionnaire, originally developed in German, has been translated into different languages and tested in different contexts, but has so far not been in use in Arabic-speaking populations. The objective of this study is to validate the Arabic version of the SRI questionnaire in a sample of Arabic-speaking patients from Lebanon. Methods Following forward/backward translations, the finalized Arabic version was administered to 149 patients (53 males–96 females, age 69.80 ± 10 years) receiving HMV. Patients were recruited from outpatient clinics and visited at home. The Arabic SRI and the 36-Item Short-Form Health Survey (SF-36) were administered, in addition to questions on sociodemographics and medical history. Exploratory Factor Analysis (EFA) was used to explore dimensionality; internal consistency reliability of the unidimensional scale and its subscales was assessed using Cronbach’s alpha. External nomological validity was examined by assessing the correlation between the SRI and SF-36 scores. Results The 49-item Arabic SRI scale showed a high internal consistency reliability (Cronbach alpha for the total scale was 0.897 and ranged between 0.73 and 0.87 for all subscales). Correlations between the SF-36-Mental Health Component MHC and SF-36-Physical Health Component with SRI-Summary Scale were 0.57 and 0.66, respectively, with higher correlations observed between the SF-36 and specific sub-scales such as the Physical Functioning and the Social Functioning subscales [r = 0.81 and r = 0.74 (P < 0.01), respectively]. Conclusion and recommendations The Arabic SRI is a reliable and valid tool for assessing HRQL in patients with chronic respiratory insufficiency receiving home mechanical ventilation.

Treatment Considerations for Adolescents Who Exhibit Cognitive/Communication Problems: A Neuroscience Perspective

2020 ◽  
Vol 5 (6) ◽  
pp. 1767-1775
Author(s):  
Martha S. Burns
Keyword(s):  
Social Communication ◽  
Transition Period ◽  
Clinical Intervention ◽  
Review Article ◽  
Sensitive Period ◽  
Clinical Implications ◽  
Evidence Based ◽  
Communication Problems ◽  
Treatment Considerations ◽  
Behavioral Growth

Purpose Adolescence is a period of substantial neurophysiological and behavioral growth, representing a second sensitive period of brain development. It is a psychological and social transition period between childhood and adulthood with many beneficial changes occurring, especially with respect to potential responsiveness to clinical intervention. However, adolescent behavioral complexities introduce clinical challenges as well. The purpose of this review article is to review the current neuroimaging research on neurophysiological changes observed during adolescence and the cognitive and social behavioral counterparts, with specific attention to the clinical implications. The review article will then summarize currently available intervention tools that can be utilized by speech-language pathologists working with this population. It will conclude with available evidence-based social-communication approaches that may be applicable as well as available evidence-based supplemental technological cognitive interventions that may be useful in working with adolescents who exhibit language and communication issues. Conclusion As a transition period between childhood and adulthood, adolescence represents a second sensitive period during which there is opportunity for clinically derived beneficial cognitive and communication growth.

scholarly journals Non-Oncological Neuroradiological Manifestations in NF1 and Their Clinical Implications

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1831
Author(s):  
Camilla Russo ◽  
Carmela Russo ◽  
Daniele Cascone ◽  
Federica Mazio ◽  
Claudia Santoro ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Structural Organization ◽  
Neurofibromatosis Type ◽  
Review Article ◽  
Tumor Suppressor Protein ◽  
Clinical Implications ◽  
Nf1 Gene ◽  
The Central Nervous System

Neurofibromatosis type 1 (NF1), the most frequent phakomatosis and one of the most common inherited tumor predisposition syndromes, is characterized by several manifestations that pervasively involve central and peripheral nervous system structures. The disorder is due to mutations in the NF1 gene, which encodes for the ubiquitous tumor suppressor protein neurofibromin; neurofibromin is highly expressed in neural crest derived tissues, where it plays a crucial role in regulating cell proliferation, differentiation, and structural organization. This review article aims to provide an overview on NF1 non-neoplastic manifestations of neuroradiological interest, involving both the central nervous system and spine. We also briefly review the most recent MRI functional findings in NF1.

scholarly journals Dyspnea on Exercise Is Associated with Overall Symptom Burden in Patients with Chronic Respiratory Insufficiency

2021 ◽  
Vol 2 (1) ◽  
pp. 48-53
Author(s):  
Heidi A. Rantala ◽  
Sirpa Leivo-Korpela ◽  
Juho T. Lehto ◽  
Lauri Lehtimäki
Keyword(s):  
Respiratory Insufficiency ◽  
Symptom Burden ◽  
Chronic Respiratory Insufficiency

scholarly journals NOVOSTI V OBRAVNAVI PLJUČNE BOLEZNI PRI OTROCIH IN MLADOSTNIKIH S CISTIČNO FIBROZO

2015 ◽  
Vol 84 (2) ◽  
Author(s):  
Marina Praprotnik ◽  
Ana Kotnik Pirš ◽  
Barbara Salobir ◽  
Majda Oštir ◽  
Matjaž Turel ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Transplantation ◽  
Lung Disease ◽  
Respiratory Insufficiency ◽  
Clinical Skills ◽  
Holistic Approach ◽  
Patient Registries ◽  
Recent Developments ◽  
Chronic Respiratory Insufficiency ◽  
Infection And Inflammation

Cystic fibrosis (CF) is a multi-organ disease,  affecting mostly lungs and gastrointestinal tract. Data from patient registries show that the survival of patients with CF has progressively improved over the past several decades, as a result of advances in antibiotic treatment, supplementation of pancreatic enzymes, better nutrition and a holistic approach to treatment in CF centres.The purpose of this review is to survey recent developments in the treatment of lung disease  in children and adolescents with CF.We describe newborn screening for CF.When chronic respiratory insufficiency occurs, lung transplantation becomes a very important issue.Lung disease is the most common cause of morbidity and mortality in CF patients. Emerging new therapies are targeted at all points in the pathogenesis of lung disease, from drugs that treat infection and inflammation in the airways to gene transfer studies  and to drugs that augment airway surface liquid height. A number of antibacterial agents formulated for inhalation are at various stages of study and there are several anti-inflammatory candidate drugs in  clinical trials.  The most important development  in the recent years is  modulation of the abnormal protein that causes CF, the cystic fibrosis transmembrane regulator (CFTR), where drugs are targeted at specific defects in the transcription, processing or functioning.When chronic respiratory insufficiency occurs, lung transplantation becomes a very important issue. The role of the CF nurse, who has responsibilities in educating and teaching clinical skills to patients and families, is described.

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