scholarly journals Association of angiotensin-converting enzyme insertion/deletion gene polymorphism with susceptibility of minimal change nephrotic syndrome in Asians: a meta-analysis

2012 ◽  
Vol 13 (3) ◽  
pp. 407-407 ◽  
Author(s):  
T-B Zhou ◽  
Z Chen ◽  
Y-H Qin ◽  
H-L Xu
Keyword(s):  
Nephrotic Syndrome ◽  
Gene Polymorphism ◽  
Angiotensin Converting Enzyme ◽  
Meta Analysis ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change ◽  
Converting Enzyme

scholarly journals Association of angiotensin converting enzyme insertion/deletion gene polymorphism with idiopathic nephrotic syndrome susceptibility in children: a meta-analysis

2011 ◽  
Vol 12 (4) ◽  
pp. 601-610 ◽  
Author(s):  
Tian-Biao Zhou ◽  
Chao Ou ◽  
Yuan-Han Qin ◽  
Li-Na Su ◽  
Feng-Ying Lei ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Gene Polymorphism ◽  
Angiotensin Converting Enzyme ◽  
Idiopathic Nephrotic Syndrome ◽  
Meta Analysis ◽  
Positive Association ◽  
Converting Enzyme ◽  
Positive Role ◽  
Different Populations ◽  
Search And Selection

Background and objective: Angiotensin converting enzyme (ACE) gene contains either an insertion (I) allele or a deletion (D) allele forming three potential genotypes: II, ID and DD. The D allele or DD genotype has been reported to be associated with higher plasma ACE level. An assessment of the association between ACE I/D gene polymorphism and idiopathic nephrotic syndrome (INS) susceptibility in children is still controversial. This meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and the onset of INS. Method: A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases, and eligible investigations were synthesized using the meta-analysis method. Results: Nine investigations were identified for the analysis of association between ACE I/D gene polymorphism and INS risk in children, including six in Asians, one study for Caucasians and two for Africans. There was positive association between D allele or DD genotype and INS susceptibility in Asians (OR = 1.75, p = 0.01; OR = 2.01, p = 0.02), but not for Caucasian children and Africans (for Caucasians, D: OR=1.35, p = 0.27, DD: OR = 0.95, p = 0.91; for Africans, D: OR = 1.70, p = 0.56, DD: OR = 1.60, p = 0.73). Furthermore, II homozygous seemed to play a positive role against INS onset for Asians (OR = 0.59, p = 0.02), but the link between II genotype and INS risk was not observed in Caucasian children and Africans (Caucasians: OR = 0.31, p = 0.06; Africans: OR = 0.50, p = 0.59). Conclusions: D allele and DD homozygous might become significant genetic molecular markers for INS susceptibility in Asian children, but the association was not observed in Caucasians or Africans. However, the conclusion from our study cannot be sustained and more investigations on larger sample in different populations are required to further clarify the role of D allele or DD homozygous in the onset of INS in difference races.

scholarly journals A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and steroid-sensitive nephrotic syndrome in children

2011 ◽  
Vol 13 (1) ◽  
pp. 175-183 ◽  
Author(s):  
Tian-Biao Zhou ◽  
Yuan-Han Qin ◽  
Chao Ou ◽  
Li-Na Su ◽  
Feng-Ying Lei ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Gene Polymorphism ◽  
Angiotensin Converting Enzyme ◽  
Meta Analysis ◽  
Positive Association ◽  
Protective Role ◽  
Cochrane Library ◽  
Converting Enzyme ◽  
Steroid Sensitive Nephrotic Syndrome ◽  
Steroid Sensitive

Background and objective: Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism correlates with circulating and cellular ACE concentration. Association between ACE I/D gene polymorphism and steroid-sensitive nephrotic syndrome (SSNS) risk in children is still controversial. This meta-analysis was performed to evaluate the relation between ACE I/D gene polymorphism and SSNS susceptibility in children. Methods: The relevant investigations were screened from the search engines of PubMed, Cochrane Library and CBM-disc (China Biological Medicine Database) as of 1 March 2011, and eligible studies were synthesized using meta-analysis methods. Results: Ten studies were identified for the analysis of association between ACE I/D gene polymorphism and SSNS risk in children, including seven in Asians, one for Caucasians and two in Africans. There was no markedly positive association between D allele or DD genotype and SSNS susceptibility in Asians, Caucasians and Africans (D: Asians OR = 1.24, p = 0.28; Caucasians OR = 1.61, p = 0.15; Africans OR = 1.61, p = 0.53; DD: Asians OR = 1.72, p = 0.15; Caucasians OR = 1.39, p = 0.48; Africans OR = 1.80, p = 0.56). Furthermore, II homozygous seemed not to play a protective role against SSNS onset for Asians, Caucasians and Africans (Asians OR = 0.95, p = 0.85; Caucasians OR = 0.30, p = 0.11; Africans OR = 0.60, p = 0.65). Conclusions: There was no association between ACE I/D gene polymorphism and SSNS susceptibility in Asians, Caucasians and Africans. However, the conclusions for Caucasians and Africans were less powerful.

scholarly journals Influence of low birth weight on minimal change nephrotic syndrome in children, including a meta-analysis

2008 ◽  
Vol 23 (5) ◽  
pp. 1615-1620 ◽  
Author(s):  
N. Teeninga ◽  
M. F. Schreuder ◽  
A. Bokenkamp ◽  
H. A. D.-v. d. Waal ◽  
J. A.E. v. Wijk
Keyword(s):  
Nephrotic Syndrome ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Meta Analysis ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change
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