scholarly journals THE DEVELOPMENT OF LYSOSOMES IN RAT SKELETAL MUSCLE IN TRICHINOUS MYOSITIS

1966 ◽  
Vol 14 (5) ◽  
pp. 396-400 ◽  
Author(s):  
DAVID M. MAEIR ◽  
HERMAN ZAIMAN
Keyword(s):  
Skeletal Muscle ◽  
Enzyme Activity ◽  
Acid Phosphatase ◽  
Striated Muscle ◽  
Muscle Fibers ◽  
Regenerative Process ◽  
Rat Skeletal Muscle ◽  
Thiamine Pyrophosphatase ◽  
Pyrophosphatase Activity

Rat striated muscle (gastroenemius) containing encysted Trichinella larvae was studied histochemically for hydrolases associated with lysosomes. Activity of the enzymes studied (acid phosphatase, esterase, aminopeptidase), not demonstrable in appreciable amounts in normal striated muscle, appears in the altered muscle fibers in granules which by various criteria are demonstrated to be lysosomes. The increase in lysosomal enzyme activity is accompanied by increased prominence of the Golgi apparatus, as demonstrated by thiamine pyrophosphatase activity, and by an increase in the ribonucleoprotein content of the muscle fibers. These changes illustrate the facultative development of lysosomes and their associated ferments during a regenerative process. They suggest the need for a revision of the classic concept of the primarily degenerative nature of the trichinous lesion as well as a possible role of the developing lysosomes in this process.

scholarly journals The Recent Understanding of the Neurotrophin's Role in Skeletal Muscle Adaptation

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Kunihiro Sakuma ◽  
Akihiko Yamaguchi
Keyword(s):  
Skeletal Muscle ◽  
Neuromuscular Disorders ◽  
Muscle Fibers ◽  
Brain Disorders ◽  
Muscle Adaptation ◽  
Bdnf Mrna ◽  
Pathological Conditions ◽  
Development And Differentiation ◽  
And Function

This paper summarizes the various effects of neurotrophins in skeletal muscle and how these proteins act as potential regulators of the maintenance, function, and regeneration of skeletal muscle fibers. Increasing evidence suggests that this family of neurotrophic factors influence not only the survival and function of innervating motoneurons but also the development and differentiation of myoblasts and muscle fibers. Muscle contractions (e.g., exercise) produce BDNF mRNA and protein in skeletal muscle, and the BDNF seems to play a role in enhancing glucose metabolism and may act for myokine to improve various brain disorders (e.g., Alzheimer's disease and major depression). In adults with neuromuscular disorders, variations in neurotrophin expression are found, and the role of neurotrophins under such conditions is beginning to be elucidated. This paper provides a basis for a better understanding of the role of these factors under such pathological conditions and for treatment of human neuromuscular disease.

scholarly journals Role of Nebulin on Actomyosin Interaction Studied in situ in Demembranated Skeletal Muscle Fibers from Newborn Mice

2009 ◽  
Vol 96 (3) ◽  
pp. 127a
Author(s):  
M.L. Bang ◽  
M. Caremani ◽  
E. Brunello ◽  
R. Littlefield ◽  
R. Lieber ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Fibers ◽  
Newborn Mice ◽  
Skeletal Muscle Fibers ◽  
Actomyosin Interaction

Extracellular divalent cations in excitation–contraction coupling: hypertonic solution effects

1982 ◽  
Vol 60 (4) ◽  
pp. 440-445
Author(s):  
Isao Oota ◽  
Isao Kosaka ◽  
Torao Nagai ◽  
Hideyo Yabu
Keyword(s):  
Skeletal Muscle ◽  
Divalent Cations ◽  
Muscle Fibers ◽  
Hypertonic Solution ◽  
Excitation Contraction Coupling ◽  
Contraction Coupling ◽  
Skeletal Muscle Fibers ◽  
Membrane Bound

It is the purpose of this article to point out that the membrane-bound Ca plays an important role in excitation–contraction (E–C) coupling of skeletal muscle fibers and that other divalent cations are unable to substitute for this role of membrane-bound Ca.

Glycogen Depletion in Rat Skeletal Muscle Fibers During Exercise

1975 ◽  
pp. 397-401 ◽  
Author(s):  
R. B. Armstrong ◽  
C. W. Saubert ◽  
W. L. Sembrowich ◽  
R. E. Shepherd ◽  
P. D. Gollnick
Keyword(s):  
Skeletal Muscle ◽  
Muscle Fibers ◽  
Glycogen Depletion ◽  
Rat Skeletal Muscle ◽  
Skeletal Muscle Fibers

Excitation-contraction latencies in postnatal rat skeletal muscle fibers

1970 ◽  
Vol 29 (1) ◽  
pp. 142-151 ◽  
Author(s):  
Edward R. Chaplin ◽  
George W. Nell ◽  
Sheppard M. Walker
Keyword(s):  
Skeletal Muscle ◽  
Muscle Fibers ◽  
Rat Skeletal Muscle ◽  
Skeletal Muscle Fibers

EFFECT OF HIGH DOSES OF AMYTAL ON SKELETAL MUSCLE

1951 ◽  
Vol 29 (3) ◽  
pp. 79-82
Author(s):  
Bernard E. Riedel ◽  
Mervyn J. Huston
Keyword(s):  
Skeletal Muscle ◽  
Synergistic Effect ◽  
Striated Muscle ◽  
Direct Action ◽  
Muscle Fibers ◽  
Electrical Stimulus ◽  
High Doses

Sodium amytal, 350 mgm. per kgm., injected intraperitoneally into rats caused a marked depression in the response of normal and denervated striated muscle to electrical stimulus. It is believed that the effect is due primarily to a direct action on the muscle. Sodium amytal and curare have a synergistic effect in depression of muscle fibers.

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