Adaptive function in preschoolers in relation to developmental delay and diagnosis of autism spectrum disorders: Insights from a clinical sample

Autism ◽  
2012 ◽  
Vol 17 (6) ◽  
pp. 743-753 ◽  
Author(s):  
Susan L Milne ◽  
Jenny L McDonald ◽  
Elizabeth J Comino
Keyword(s):  
Autism Spectrum Disorders ◽  
Developmental Delay ◽  
Clinical Sample ◽  
Autism Spectrum ◽  
Adaptive Function ◽  
Spectrum Disorders

scholarly journals Dopaminergic Gene Dosage in Autism versus Developmental Delay: From Complex Networks to Machine Learning approaches

2020 ◽  
Author(s):  
André Santos ◽  
Francisco Caramelo ◽  
Joana Barbosa de Melo ◽  
Miguel Castelo-Branco
Keyword(s):  
Machine Learning ◽  
Autism Spectrum Disorders ◽  
Network Analysis ◽  
Developmental Delay ◽  
Gene Dosage ◽  
Genetic Alterations ◽  
Autism Spectrum ◽  
Compact Set ◽  
Neural Basis ◽  
Spectrum Disorders

AbstractThe neural basis of behavioural changes in Autism Spectrum Disorders (ASD) remains a controversial issue. One factor contributing to this challenge is the phenotypic heterogeneity observed in ASD, which suggests that several different system disruptions may contribute to diverse patterns of impairment between and within study samples. Here, we took a retrospective approach, using SFARI data to study ASD by focusing on participants with genetic imbalances targeting the dopaminergic system. Using complex network analysis, we investigated the relations between participants, Gene Ontology (GO) and gene dosage related to dopaminergic neurotransmission from a polygenic point of view. We converted network analysis into a machine learning binary classification problem to differentiate ASD diagnosed participants from DD (developmental delay) diagnosed participants. Using 1846 participants to train a Random Forest algorithm, our best classifier achieved on average a diagnosis predicting accuracy of 85.18% (sd 1.11%) on a test sample of 790 participants using gene dosage features. In addition, we observed that if the classifier uses GO features it was also able to infer a correct response based on the previous examples because it is tied to a set of biological process, molecular functions and cellular components relevant to the problem. This yields a less variable and more compact set of features when comparing with gene dosage classifiers. Other facets of knowledge-based systems approaches addressing ASD through network analysis and machine learning, providing an interesting avenue of research for the future, are presented through the study.Lay SummaryThere are important issues in the differential diagnosis of Autism Spectrum Disorders. Gene dosage effects may be important in this context. In this work, we studied genetic alterations related to dopamine processes that could impact brain development and function of 2636 participants. On average, from a genetic sample we were able to correctly separate autism from developmental delay with an accuracy of 85%.

scholarly journals Cerebral Palsy, Autism Spectrum Disorders, and Developmental Delay in Children Born After Assisted Conception

2009 ◽  
Vol 163 (1) ◽  
pp. 72 ◽  
Author(s):  
Dorte Hvidtjørn ◽  
Laura Schieve ◽  
Diana Schendel ◽  
Bo Jacobsson ◽  
Claus Sværke ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Autism Spectrum Disorders ◽  
Developmental Delay ◽  
Autism Spectrum ◽  
Assisted Conception ◽  
Spectrum Disorders

scholarly journals Evaluating the appropriateness of a new computer-administered measure of adaptive function for children and youth with autism spectrum disorders

Autism ◽  
2015 ◽  
Vol 20 (1) ◽  
pp. 14-25 ◽  
Author(s):  
Wendy J Coster ◽  
Jessica M Kramer ◽  
Feng Tian ◽  
Meghan Dooley ◽  
Kendra Liljenquist ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Autism Spectrum ◽  
Children And Youth ◽  
Adaptive Function ◽  
Spectrum Disorders

scholarly journals The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly

2009 ◽  
Vol 11 (2) ◽  
pp. 111-117 ◽  
Author(s):  
Elizabeth A Varga ◽  
Matthew Pastore ◽  
Thomas Prior ◽  
Gail E Herman ◽  
Kim L McBride
Keyword(s):  
Autism Spectrum Disorders ◽  
Developmental Delay ◽  
Autism Spectrum ◽  
Clinical Pediatric ◽  
Spectrum Disorders

scholarly journals Deletions in chromosome 6p22.3-p24.3, including ATXN1, are associated with developmental delay and autism spectrum disorders

2012 ◽  
Vol 5 (1) ◽  
pp. 17 ◽  
Author(s):  
Patrícia BS Celestino-Soper ◽  
Cindy Skinner ◽  
Richard Schroer ◽  
Patricia Eng ◽  
Jayant Shenai ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Developmental Delay ◽  
Autism Spectrum ◽  
Spectrum Disorders

scholarly journals Simple Mindreading Abilities Predict Complex Theory of Mind: Developmental Delay in Autism Spectrum Disorders

2017 ◽  
Vol 47 (9) ◽  
pp. 2743-2756 ◽  
Author(s):  
Maria Chiara Pino ◽  
Monica Mazza ◽  
Melania Mariano ◽  
Sara Peretti ◽  
Dagmara Dimitriou ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Theory Of Mind ◽  
Developmental Delay ◽  
Autism Spectrum ◽  
Complex Theory ◽  
Spectrum Disorders
Sign in / Sign up

Export Citation Format

Share Document