scholarly journals Anti-tumorigenic effects of a novel digitoxin derivative on both estrogen receptor–positive and triple-negative breast cancer cells

Tumor Biology ◽  
2017 ◽  
Vol 39 (6) ◽  
pp. 101042831770533 ◽  
Author(s):  
Yogesh M Kulkarni ◽  
Juan S Yakisich ◽  
Neelam Azad ◽  
Rajkumar Venkatadri ◽  
Vivek Kaushik ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Estrogen Receptor Positive

scholarly journals Agonists and knockdown of estrogen receptor β differentially affect invasion of triple-negative breast cancer cells in vitro

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Susanne Schüler-Toprak ◽  
Julia Häring ◽  
Elisabeth C. Inwald ◽  
Christoph Moehle ◽  
Olaf Ortmann ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Estrogen Receptor Β

Novel thiosemicarbazones induce high toxicity in estrogen-receptor-positive breast cancer cells (MCF7) and exacerbate cisplatin effectiveness in triple-negative breast (MDA-MB231) and lung adenocarcinoma (A549) cells

2019 ◽  
Vol 38 (3) ◽  
pp. 558-573
Author(s):  
Estefany Ingrid Medina-Reyes ◽  
Marco Antonio Mancera-Rodríguez ◽  
Norma Laura Delgado-Buenrostro ◽  
Adriana Moreno-Rodríguez ◽  
Juan Luis Bautista-Martínez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
A549 Cells ◽  
High Toxicity ◽  
Estrogen Receptor Positive ◽  
Lung Adenocarcinoma A549 ◽  
Positive Breast Cancer

scholarly journals Estrogen Receptor Mediates the Radiosensitivity of Triple-Negative Breast Cancer Cells

2017 ◽  
Vol 23 ◽  
pp. 2674-2683 ◽  
Author(s):  
Xingxing Chen ◽  
Ningyi Ma ◽  
Zhirui Zhou ◽  
Ziliang Wang ◽  
Qunchao Hu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative

scholarly journals The Aryl Hydrocarbon Receptor Undergoes Chaperone-Mediated Autophagy in Triple-Negative Breast Cancer Cells

2021 ◽  
Vol 22 (4) ◽  
pp. 1654
Author(s):  
Jinyun Chen ◽  
Yujie Yang ◽  
Wade A. Russu ◽  
William K. Chan
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Aryl Hydrocarbon Receptor ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
26S Proteasome ◽  
Aryl Hydrocarbon ◽  
Chaperone Mediated Autophagy

The aryl hydrocarbon receptor (AHR) is a ligand-activated signaling molecule expressed in many cell types, including triple-negative and non-triple-negative breast cancer cells. It affects breast cancer growth and crosstalk with estrogen receptor signaling. Normally, this receptor is degraded shortly after ligand activation via the 26S proteasome. Here, we report that AHR undergoes chaperone-mediated autophagy in MDA-MB-468 triple-negative breast cancer cells. This lysosomal degradation of AHR exhibits the following characteristics: (1) it is triggered by 6 amino-nicotinamide, starvation, and piperazinylpyrimidine compound Q18; (2) it is not observed in non-triple-negative breast cancer cells (MCF-7, T47D, and MDA-MB-361); (3) it can be inhibited by progesterone receptor B but not estrogen receptor alpha; (4) it can be reversed by chloroquine but not MG132; (5) it requires LAMP2A; and (6) it involves AHR-HSC70 and AHR-LAMP2A interactions. The NEKFF sequence localized at amino acid 558 of human AHR appears to be a KFERQ-like motif of chaperone-mediated autophagy, responsible for the LAMP2A-mediated AHR protein degradation.

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