Studies on hypoglycaemic effects of polyherbal preparation in streptozotocin-induced diabetic male albino rats

2009 ◽  
Vol 28 (11) ◽  
pp. 679-687
Author(s):  
A. Ismail Khan ◽  
S. Yuvaraj ◽  
E. Suthagar ◽  
C. Parthasarathy ◽  
K. Balasubramanian
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Skeletal Muscles ◽  
Glucose Oxidation ◽  
Serum Insulin ◽  
Insulin Level ◽  
Diabetic Rats ◽  
Vehicle Group ◽  
Albino Rats ◽  
Serum Insulin Level

Many traditional treatments have been recommended in the alternative system of medicine for diabetes mellitus. However, the mode of action of most of the herbals used has not been defined. It has been reported that sex hormones are important regulators of insulin-mediated events in skeletal muscles. In view of this, a novel herbal preparation containing antidiabetic and aphrodisiac plants was used in the present study. Adult male albino rats were divided into following groups after induction of diabetes. Rats were given an intraperitoneal (i.p.) injection of streptozotocin (STZ), at a dose of 65 mg/kg body weight after overnight fasting, to induce diabetic state with blood glucose levels >250 mg/dL. Group 1—Control rats treated with single i.p. injection of vehicle, Group 2—Rats treated with polyherbal preparation (PHP; 500 mg/kg body weight by oral intubation, morning and evening for 30 days), Group 3—STZ-diabetic rats treated orally with equal volumes of vehicle (water) alone and Group 4—STZ-diabetic rats treated with PHP after 10 days of diabetic induction. STZ-diabetes decreased the body weight, serum insulin level and glucose oxidation in liver and skeletal muscles but increased the fasting blood glucose level. After polyherbal treatment, body weight and glucose oxidation were completely restored to control level while serum insulin level was restored partially and the glucose tolerance was significantly improved. There was a significant decrease in total haemoglobin (Hb) level of diabetic rats when compared to control but polyherbal treatment significantly improved the same. However, the other parameters studied (red blood cell [RBC], white blood corpuscle [WBC], packed cell volume [PCV], mean corpuscular volume [MCV] and mean corpuscular haemoglobin [MCH]) were unaltered. In conclusion, the anti-diabetic properties of PHP appear to be mediated through pancreatic β-cell regeneration, resulting in maintenance of optimal blood glucose and its oxidation in liver and skeletal muscles.

scholarly journals Anti-diabetic effect of metformin combined with peanut (Arachis hypogaea L.) on streptozotocin induced diabetic rats

2018 ◽  
Vol 13 (2) ◽  
pp. 59-67
Author(s):  
Shehrina Nazmin ◽  
Nayma Sultana
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Arachis Hypogaea ◽  
Serum Insulin ◽  
Insulin Level ◽  
Diabetic Rats ◽  
Diabetic Group ◽  
Glycemic Status ◽  
Final Body Weight ◽  
Arachis Hypogaea L

Background: Diabetes mellitus (DM) is a common metabolic disorder. Metformin is the initial drug of choice for treatment of type 2 DM. In many cases, metformin mono-therapy cannot effectively achieve the targeted glycemic control. However, metformin along with peanut (Arachis hypogaea L.) may reduce blood glucose level more effectively. Objective: To evaluate the anti-diabetic effect of metformin in combination with peanut on streptozotocin induced diabetic rats. Methods: This experimental study was conducted in the Department of Physiology, Sir Salimullah Medical College, in 2016. Forty (40) Wistar Albino male rats, 90-120 days old, weighing 225-240 g (initial body weight) were taken and divided into four groups containing 10 rats in each group, i.e. Non-diabetic group (ND), Streptozotocin induced diabetic group (STZ), Diabetic group treated with metformin (STZ-M) and Diabetic group treated with metformin and peanut (STZ-MP). Diabetic model was developed by giving single intraperitoneal injection of streptozotocin (50mg/kg body weight) to STZ, STZ-M and STZ-MP groups on day-1. In addition, STZ-M group received metformin (500mg/kg body weight) orally and STZ-MP group received both metformin and peanut extract orally (both 500mg/kg body weight) once daily in the morning for 21 days (day-4 to day-24). After measuring the final body weight, rats were sacrificed on day-25. To observe glycemic status, Fasting Blood Glucose (FBG), serum insulin levels were estimated and HOMA-IR was calculated. Statistical analyses were done by one way ANOVA and Bonferroni test as applicable. Results: Mean FBG level and HOMA-IR were significantly (p<0.001) higher and serum insulin level and final body weight were significantly (p<0.001) lower in STZ group when compared to those of ND group. Whereas, FBG level and HOMA-IR were significantly (p<0.001) lower and insulin level and final body weight were significantly higher (p<0.001) in both STZ-M and STZ-MP groups in comparison to those of STZ group but more profound effects were found in STZ-MP group than those of STZ-M group. Conclusion: The present study revealed that, metformin combined with peanut was more effective to control glycemic status in diabetic rats than metformin alone. J Bangladesh Soc Physiol. 2018, December; 13(2): 59-67

scholarly journals Inhibition ofα-Glucosidase by Thiosulfinate as a Target for Glucose Modulation in Diabetic Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Abdulrahman L. Al-Malki
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Hydrolytic Enzyme ◽  
Positive Control ◽  
Diabetic Rats ◽  
Postprandial Hyperglycemia ◽  
Postprandial Blood Glucose ◽  
Control Group ◽  
Albino Rats ◽  
Predisposing Factor

Postprandial hyperglycemia is a predisposing factor for vascular dysfunction and organ damage.α-glucosidase is a hydrolytic enzyme that increases the glucose absorption rate and subsequently elevates blood glucose levels. Garlic (Allium sativumL.) is a rich source of several phytonutrients, including thiosulfinate (THIO). The aim of this study was to evaluate the ability of THIO, a potent inhibitor of intestinalα-glucosidase, to reduce postprandial blood glucose. Male albino rats were randomly assigned to five different groups (n=10/group). Group 1 served as the control group. Groups 2–5 were injected intraperitoneally with a single dose of streptozotocin (STZ) to induce diabetes. Group 2 comprised untreated diabetic rats. Groups 3 and 4 contained diabetic rats that were given THIO orally (20 mg/kg body weight/day and 40 mg/kg body weight/day, resp.). Group 5 was the positive control having diabetic rats treated orally with acarbose (10 mg/kg body weight/day; positive control). Diabetic rats treated with THIO displayed a significant blood glucose reduction (p<0.001and < 0.01 by analysis of variance, resp.) and a significant elevation in insulin compared with that of untreated rats. THIO is an effective noncompetitive intestinalα-glucosidase inhibitor that promotes hypoglycemic action (p<0.001) in STZ-injected rats. THIO is a promising agent for the management of postprandial hyperglycemia.

scholarly journals Hypoglycaemic and Hypolipidemic Effects of Treculia africana Aqueous Leaves Extract in Alloxan Induced Diabetic Rats

2018 ◽  
pp. 1-9
Author(s):  
Idris A. Kankara ◽  
Gayus A. Paulina ◽  
M. Aliyu
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Fasting Blood Glucose ◽  
Hdl Cholesterol ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Treculia Africana

This study investigated the hypoglycaemic and hypolipidaemic effects of Treculia africana plant used in Nigeria as medicinal plant. Diabetes mellitus was induced by a single dose intraperitoneal injection of alloxan 150 mg/kg body weight. Twenty five (25) male albino rats were divided into five groups, five (5) rats per group; normal control, diabetic control and diabetic groups treated with aqueous leaves extract of 200,400 and 800 mg/Kg body weight respectively for 21 days orally. The effects of the extract on some biochemical parameters were evaluated; fasting blood glucose level was assayed using glucose oxidase method, total cholesterol and HDL –cholesterol were assayed using enzymatic method while LDL- cholesterol was determined by Friedewald equation. The results showed that, extract significantly (p<0.05) decrease the elevated fasting blood glucose levels, total cholesterol, triglyceride and LDL- cholesterol when compared with the diabetic control rats. The extract also caused significant (p<0.05) increased in HDL –cholesterol and body weight when compared with diabetic control rats. Aqueous leave extract of Treculia africana possess hypoglycemic effect and the most effective dose was 800 mg/Kg body weight in amelioration of hyperglycaemia and most all toxicity effects of alloxan on lipid profile.

scholarly journals Can troxerutin pretreatment prevent testicular complications in prepubertal diabetic male rats?

2020 ◽  
Vol 54 (2) ◽  
pp. 85-95
Author(s):  
Afsaneh Ghadiri ◽  
Fariba Mirzaei Bavil ◽  
Gholam Reza Hamidian ◽  
Hajar Oghbaei ◽  
Zohreh Zavvari Oskuye ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Blood Glucose ◽  
Serum Insulin ◽  
Insulin Level ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Male Rats ◽  
Male Wistar Rats ◽  
Apoptosis Process

AbstractObjective. The vast majority of type 1 diabetes leads to a higher prevalence of reproductive system’s impairments. Troxerutin has attracted much attention owing to its favorable properties, including antihyperglycemic, anti-inflammatory, and antiapoptotic effects. This investigation was proposed to evaluate whether pretreatment with troxerutin could prevent apoptosis-induced testicular disorders in prepubertal diabetic rats.Methods. Fifty prepubertal male Wistar rats were randomly allocated into five groups: control (C), troxerutin (TX), diabetic (D), diabetic+troxerutin (DTX), and diabetic+insulin (DI). Diabetes was induced by 55 mg/kg of streptozotocin applied intraperitoneally. In TX and DTX groups, 150 mg/kg troxerutin was administered by oral gavage. Diabetic rats in DI group received 2–4 U NPH insulin subcutaneously. Troxerutin and insulin treatments were begun immediately on the day of diabetes confirmation. After 30 days, the testicular lipid peroxidation and antioxidant activity, apoptosis process, and stereology as well as serum glucose and insulin levels were assessed.Results. The results showed that diabetes caused a significant increase in the blood glucose, the number of TUNEL positive cells and tubules, and the malondialdehyde level as well as a significant decrease in serum insulin level compared to controls. The stereological analysis also revealed various alterations in diabetic rats compared to controls. Troxerutin treatment improved these alterations compared to the diabetic group.Conclusion. Troxerutin-pretreatment may play an essential role in the management of the type-1 diabetes-induced testicular disorders by decreasing blood glucose and modulating apoptosis.

scholarly journals Hypoglycemic and hypolipidemic activity of combined milk thistle and fenugreek seeds in alloxan-induced diabetic albino rats

2020 ◽  
Vol 13 (8) ◽  
pp. 1732-1736
Author(s):  
Mohamed Jamal Saadh
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Oral Administration ◽  
Glycosylated Hemoglobin ◽  
Diabetic Rats ◽  
Antidiabetic Drugs ◽  
Albino Rats ◽  
Milk Thistle ◽  
Fenugreek Seeds ◽  
Ameliorative Effect

Background and Aim: Despite the availability of antidiabetic drugs, they are not free from associated adverse side effects. This study aimed to evaluate the hypoglycemic and hypolipidemic effects of oral administration of seeds from two medicinal plants: (1) Milk thistle and (2) fenugreek. Materials and Methods: Plant seeds were washed in distilled water and ground with a coffee grinder. Alloxan was used to induce diabetes in 20 male albino rats. Diabetic rats were randomly divided into two groups: (1) Group 1 (n=10), diabetic rats fed with 0.5 g/kg milk thistle and 2 g/kg fenugreek seeds per day and (2) Group 2 (n=10), diabetic rats fed standard rodent food for 4 weeks. Results: Oral administration of milk thistle and fenugreek seeds for 2 weeks resulted in significant improvement in body weight, blood glucose, glycosylated hemoglobin (HbA1c), cholesterol, and triglyceride levels in alloxan-induced diabetic rats. After 4 weeks, this ameliorative effect was significantly elevated with respect to blood glucose (155.00±9.70 mg/ dL vs. 427.50±5.70 mg/dL; p<0.001), HbA1c (5.5±0.19% vs. 13.65±1.77%; p<0.001), cholesterol (281.50±10.95 mg/dL vs. 334.30±6.80 mg/dL; p<0.001), triglyceride (239.60±6.87 mg/dL vs. 284.20±9.95 mg/dL; p<0.01), and body weight (265.30±8.10 g vs. 207.40±11.4 g; p<0.01) as compared with non-treated diabetic rats. Conclusion: Milk thistle and fenugreek seeds possess hypoglycemic and hypolipidemic properties and could be used as natural compounds that are suitable as parent compounds for the development of new antidiabetic drugs.

scholarly journals Anti-hyperglycemic Effects of Diacerein in Alloxan-Induced Diabetes Mellitus in Wistar Albino Rats

2020 ◽  
pp. 107-113
Author(s):  
Arsalan Uqaili ◽  
Samia Siddiqui ◽  
Roomi Aijaz ◽  
Yar Muhammad Nizammani ◽  
Navaid Kazi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Blood Glucose ◽  
Treated Group ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Control Group ◽  
Albino Rats ◽  
Group B ◽  
Group D

Objective: To determine the anti-hyperglycemic effects of interleukin-1 inhibitor (diacerein) in alloxan induced diabetic albino wistar rats. This experimental study was performed at the Department of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tando Jam within 6 months from April 2016 to September 2016. Total of 160 adult Albino Wistar Rats having an average of 200 to 300 grams body weights were selected. Animals were categorized into 4 groups as; Group A (n=15): Control rats – receive 0.9% normal saline as placebo Experimental Groups Group B (n=15): Experimental Control (Diabetic rats) - Alloxan50 mg/kg body weight intraperitoneal. Group C (n=15): Diabetic rats + Diacerein (30 mg/kg/day) orally daily. Group D (n=15): Diabetic rats + Diacerein (50 mg/kg/day) orally daily. Animals were kept and treated as per the NIH Guideline for Use and Care of Laboratory Animals. Diabetes mellitus was induced via a single intraperitoneal injection of 50 milligram/kg alloxan monohydrated dissolved in aseptic 0.9% saline. After 72 hours, blood specimens were taken from the caudal vein of the rats and glucose level>200 mg/dL was taken as diabetes. Experimental rats were given diacerein approximately 30 and 50 mg orally for 6 weeks. At the completion of experiment the body weight was measured of each animal by electronic measuring balance and blood sample was taken from each animal of all groups to assess the blood glucose level and HbA1c level. Data were recorded via self-made proforma and analysis was done by using SPSS version 20. Results: Average body weight of Diabetic control (Group B) was 193.33±22.50 grams, which was lower in contrast to Diacerein treated group C 202.47±25.70 grams and significantly lower as compared to Diacerein treated group D as  212.6±23.43 grams. A significant increase in blood glucose levels 182.07±10.63 mg/dl was noted in the Diabetic control (Group B) compared to Diacerein treated group C (110.13± 8.54 mg/dl) and group D (85.87±8.41 mg/dl) (P=0.001). HbA1c was markedly raised in the Group B- diabetic controls, while diacerein treated diabetic rats (groups C and D) showed a significant decrease in HbA1c (P=0.001). Conclusion: It was concluded that Diacerein achieves the Euglycemic state by reducing the levels of blood glucose and glycated hemoglobin (HbA1c) in Alloxan-Induced diabetes mellitus in Wistar Albino Rats.

The anti-diabetic effect of some plant extracts against Streptozotocin - induced diabetes type 2 in male albino rats.

2020 ◽  
Vol 20 ◽  
Author(s):  
Heba F. Gomaa ◽  
Imen Ben Abdelmalek ◽  
Khaled G. Abdel-Wahhab
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Total Cholesterol ◽  
Plant Extracts ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
Male Rats ◽  
Postprandial Blood Glucose ◽  
Albino Rats

Background: One of the widely spread disorders is Diabetes mellitus, especially type 2 (T2DM). T2DM is attributed to the change in life style and stress. A possible strategy to block dietary carbohydrate absorption, is regulation of postprandial blood glucose level as well, the use of some natural plant extracts with inhibitory effect against carbohydrate digestive enzymes such as alpha-amylase and fewer side effects than synthetic drugs. This study was conducted to investigate the anti-diabetic effect of Cinnamon and Saussurea extract, individually, on blood glucose, lipid profile, insulin, interleukin1-beta and weight loss in diabetic rats treated with Streptozotocin (STZ). Methods: The experiment was performed on 60 Wistar male rats, the experimental study include 6 groups (10 rats each): (I) normal rats, (II) Streptozotocin- induced diabetic rats, (III) normal rats orally received (200 mg/kg/day) Saussurea ethanolic extract (SEE) for consecutive 4 weeks, (IV) normal rats orally received (100mg/kg/day) Cinnamon aqueous extract (CAE) for consecutive 4 weeks, (V) Streptozotocin –treated rats received SEE orally (200mg /kg/ day) for consecutive 4 weeks, and (VI) Streptozotocin –treated rats received CAE orally (100mg /kg/ day) for consecutive 4 weeks. Results: The results of the following study revealed that SEE has more anti-diabetic effect against Streptozotocin treatment than CAE due to the high α-amylase inhibition potential and higher phenolic content, Also, GC-MS analysis of SEE exhibited higher concentrations of phenolic compounds such as : dehydrocostus lactone, azuleno, eicosa-pentaenoic acid and linoelaidic acid that revealed anti-diabetic, anti-lipidemic and anti-inflammatory activities, while CAE showed presence of cinnamic and quinic acids. Injection of STZ resulted in a decline in the insulin, high density lipoprotein and body weight values matched with increase of glucose, total cholesterol, LDL-Cholesterol, triglycerides and interleukin1- β (IL-1β). The administration of extracts of SEE and CAE into STZ-treated rats separately resulted in a decline in the elevated levels of blood glucose, total cholesterol, triglycerides and improving serum HDL-Cholesterol and body weight. Conclusion: Both tested herbal extracts performed anti-diabetic effect that mainly could be mechanized via the α-amylaseinhibitory potentials due to the high phenolic and flavonoids content.

scholarly journals Antidiabetic and antioxidant potentials of Vitellaria paradoxa barks in alloxan-induced diabetic rats

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
David Miaffo ◽  
Oulianovie Guessom Kamgue ◽  
Narcisse Ledang Tebou ◽  
Clarice Maa Maa Temhoul ◽  
Albert Kamanyi
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Antioxidant Activities ◽  
Insulin Level ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Hepatic Glycogen ◽  
Vitellaria Paradoxa ◽  
Relative Body Weight ◽  
Antioxidant Parameters

Abstract Background Vitellaria paradoxa (V. paradoxa) is a plant used in traditional medicine in the treatment of many diseases including diabetes mellitus. Although the different parts of this plant are used empirically as antidiabetic drug, no scientific work to our knowledge has yet been undertaken to evaluate its effects on blood glucose, and lipid and antioxidant parameters of diabetic animals. The objective of this study is therefore to evaluate the hypoglycaemic, hypolipidemic and antioxidant activities of the aqueous extract of V. paradoxa barks in diabetic rats. Methods Diabetes was induced by intraperitoneal injection of alloxan (120 mg/kg bw). Thirty male albino rats were divided into groups and orally treated for 14 days with distilled water, glibenclamide (2.5 mg/kg bw) and aqueous extract of V. paradoxa (125, 250 and 500 mg/kg bw). Glycaemia, insulin level, relative body weight, hepatic glycogen level, some liver enzymes, and lipid and antioxidant parameters were evaluated. Results The results showed that the extract caused a significant increase in relative body weight, insulin level, HDL-cholesterol, hepatic glycogen rate, and fructose-1,6-biphosphate and glucokinase activities. A significant decrease in glycaemia, glucose-6-phosphatase activity, total cholesterol, triglycerides and LDL-cholesterol were also observed after the administration of V. paradoxa. Glutathione level and the activities of catalase and superoxide dismutase increased significantly while the nitric oxide and malondialdehyde levels decreased significantly in the liver of animals treated with the extract of V. paradoxa. Conclusion These results justify the hypoglycaemic, hypolipidemic and antioxidant effects of aqueous extract of V. paradoxa barks, which can reduce the complications associated with diabetes.

scholarly journals Relationship of serum fasting insulin with gonadotropins in infertile women

2014 ◽  
Vol 29 (1-2) ◽  
pp. 17-24
Author(s):  
Shamima Bari ◽  
Rokeya Begum ◽  
Qazi Shamima Akter ◽  
Tanvir Alam ◽  
Kadeja Begum
Keyword(s):  
Blood Glucose ◽  
Serum Insulin ◽  
Fasting Blood Glucose ◽  
Insulin Level ◽  
Fasting Insulin ◽  
Serum Insulin Level ◽  
Fasting Serum ◽  
Infertile Women ◽  
Group B ◽  
Fertile Women

Background: Infertility has become a global health problem in the world wide affecting 8-10% of couple. It is also a matter of social injustice and inequality. Increase level of insulin has been implicated as a cause of infertility. Objective: To find out the association of fasting serum insulin level with gonadotropins in infertile women. Methods: This cross sectional study was conducted in the department of Physiology, Dhaka Medical College, Dhaka from July 2010 to June 2011. A total number of 150 female age ranged from 20 – 40 years were included in this study. Out of them100 infertile women were selected as study group (group B). Group B was subdivided into group B1 and B2. Group B1 consisted of 50 primary infertile women and group B2 consisted of 50 secondary infertile women. Rest 50 age matched apparently healthy parous women were considered as base line control group A. All the study subjects were selected from out patient department of infertility unit, BSMMU, Dhaka. The control subjects were selected by personal contact. Serum fasting insulin was measured by enzyme-link-immunosorbend assay. Fasting blood glucose and blood glucose two hours after breakfast were measured by glucose oxidase method. The Data were collected in a prescribed data sheet after taking written consent. Statistical analyses were done by unpaired students “t” tests by SPSS program version 12. The level of significance was calculated and p value <0.05 was accepted as level of significance. Results: In this study, the mean fasting serum insulin level were significantly higher in infertile women than those of fertile women (p<0.001). Within the study group serum fasting insulin was higher in primary infertile women than that of secondary infertile women both were statistically not significant. Again, serum FSH and LH levels were significantly lower (P<.0001) in infertile women than those of fertile women. But serum FSH level was lower and LH level was higher in primary infertile women than that of secondary infertile women. In addition, fasting blood glucose level was almost similar but within normal limits in all groups. Blood glucose 2HABF was significantly higher in secondary infertile women than that of fertile women but within in normal limit. Moreover, fasting serum insulin level was negatively correlated with serum FSH and LH in primary infertility but negatively correlated with serum FSH and positive correlation with serum LH in secondary infertility. Conclusion: From the above study it may be concluded that fasting serum insulin level was higher in infertile women than those of healthy fertile women. These alterations may lead to menstrual irregularities, ovulatory dysfunction and infertility. http://dx.doi.org/10.3329/bjpp.v29i1-2.20063 Bangladesh J Physiol Pharmacol 2013; 29(1&2) : 17-24

scholarly journals Antidiabetic and antihyperlipidemic activities of extracts of Barleria cuspidata Heyne ex Nees on streptozotocin induced diabetic rats

2021 ◽  
Vol 12 (1) ◽  
pp. 643-652
Author(s):  
Manohar Reddy ◽  
Raja Sundararajan
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Glycosylated Hemoglobin ◽  
Hdl Cholesterol ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Serum Triglycerides ◽  
Methanol Extracts ◽  
Glucose Levels ◽  
Blood Glucose Levels

Traditionally, Barleria cuspidata Heyne ex Nees is utilized for antidiabetic action with the absence of logical investigation. Thus, the current examination was attempted to explore for its antidiabetic and antihyperlipidemic movement in streptozotocin instigated diabetic animal models. Blood glucose levels were estimated in normoglycemic rats at initial, 60th and 120th minutes intervals and in glucose feed hyperglycemic rats at initial, 30, 60, 90 and 120 minutes after a solitary portion of streptozotocin at 55 mg/kg body weight intraperitoneal were made diabetic in albino rats. Blood glucose levels were estimated at week by week spans after everyday administration of chloroform and methanol extracts of Barleria cuspidata at dosages of 250 and 500 mg/kg body weight. Other biochemical boundaries of serum triglycerides, cholesterol, HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol, total protein, albumin, globulin, uric acid, creatinine, urea, transaminases, alkaline phosphatase, alanine aminotransaminase, insulin and glycosylated hemoglobin were likewise estimated toward the finish of the investigation. Chloroform and methanol extracts of Barleria cuspidata by an oral organization for 21 days altogether (P<0.001) decreases the elevated blood glucose extents in diabetic rats whereas in normoglycemic rats it doesn't adjust the blood glucose amounts altogether and in glucose feed hyperglycemic rats significantly decreases the raised blood glucose levels. Likewise, the chloroform and methanol extracts of Barleria cuspidata improved other biochemical boundaries related to diabetes. Moreover, the extracts of Barleria cuspidata favourable affect the histopathological changes of pancreas in streptozotocin initiated diabetic rats. Delayed consequences legitimize the traditional utilization of Barleria cuspidata for its anti-diabetic action.

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