scholarly journals Cefoxitin-Serum Creatinine Interference in a Patient With Nontuberculous Mycobacteria Ventriculomeningitis

2020 ◽  
pp. 089719002092161
Author(s):  
Dan Wang ◽  
Anthony J. Emanuel ◽  
Ron R. Neyens ◽  
Eugene Bakharev ◽  
Nikolina Babic
Keyword(s):  
Serum Creatinine ◽  
Nontuberculous Mycobacteria ◽  
Package Insert ◽  
Mycobacterium Abscessus ◽  
Critically Ill Patient ◽  
Post Infusion ◽  
Spiking Experiment ◽  
Creatinine Measurement ◽  
Serum Creatinine Measurement ◽  
Antimicrobial Regimen

Cefoxitin is a second-generation cephamycin antibiotic, which at concentrations ≥100 µg/mL is known to modestly interfere, for up to 2 hours post-infusion, with serum creatinine measurement via the traditional Jaffe-based assay. We report a case of a severe serum creatinine elevation while utilizing cefoxitin as a component of an antimicrobial regimen in a critically ill patient with Mycobacterium abscessus ventriculomeningitis. Our results, both via patient serum analysis and a cefoxitin spiking experiment, demonstrate interference despite the utilization of improved modern Jaffe-based assays. In fact, the cefoxitin-creatinine interference may be clinically relevant at concentrations 3 times lower than that listed in the package insert and may display more than a modest interference at typical therapeutic concentrations.

Impact of the biochemical assay for serum creatinine measurement on the individual carboplatin dosing

2002 ◽  
Vol 38 (1) ◽  
pp. 52-56 ◽  
Author(s):  
F. Léger ◽  
S. Séronie-Vivien ◽  
J. Makdessi ◽  
I. Lochon ◽  
J.P. Delord ◽  
...  
Keyword(s):  
Serum Creatinine ◽  
Biochemical Assay ◽  
The Individual ◽  
Creatinine Measurement ◽  
Serum Creatinine Measurement

F-28 Systematic error in MELD calculation by using serum creatinine measurement in cirrhosis

2011 ◽  
Vol 43 ◽  
pp. S100-S101
Author(s):  
E. Tsochatzis ◽  
M. Garcovich ◽  
P. Manousou ◽  
G. Germani ◽  
G. Fede ◽  
...  
Keyword(s):  
Serum Creatinine ◽  
Systematic Error ◽  
Creatinine Measurement ◽  
Serum Creatinine Measurement

Use of a synthetic soluble bilirubin derivative to assess interference in creatinine measurements

1991 ◽  
Vol 37 (2) ◽  
pp. 236-238 ◽  
Author(s):  
Carlo Franzini ◽  
Anna M Morelli ◽  
Glanpaolo Cattozzo
Keyword(s):  
Hydrogen Peroxide ◽  
Serum Creatinine ◽  
Interference Effect ◽  
Nadh Oxidation ◽  
Enzymatic Method ◽  
Negative Interference ◽  
Significant Interference ◽  
Creatinine Measurement ◽  
Serum Creatinine Measurement ◽  
Enzymatic Methods

Abstract In assessing interference from bilirubin, the use of a synthetic soluble derivative (ditaurobilirubin, DTB) is recommended as a surrogate for the natural conjugates (Bc). We compared the interference effect of unconjugated bilirubin (Bu), Bc, and DTB, using six mechanized methods for serum creatinine measurement. No significant interference was noted in methods that include removal of proteins or in an enzymatic method involving NADH oxidation. Heavy (negative) interference was observed in an alkaline picrate method, and in direct enzymatic methods based on hydrogen peroxide measurement: interference was always more pronounced in the presence of the two soluble derivatives (Bc and DTB), whose interference was of the same magnitude. These results point out the utility of testing for bilirubin interference by using soluble derivatives, in addition to Bu, and suggest the feasibility of using DTB as a surrogate for Bc for this purpose.

Serum Creatinine Measurement Immediately After Cardiac Surgery and Prediction of Acute Kidney Injury

2012 ◽  
Vol 59 (2) ◽  
pp. 196-201 ◽  
Author(s):  
Julie Ho ◽  
Martina Reslerova ◽  
Brent Gali ◽  
Peter W. Nickerson ◽  
David N. Rush ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Serum Creatinine ◽  
Kidney Injury ◽  
Creatinine Measurement ◽  
Serum Creatinine Measurement

How well do Croatian laboratories adhere to national recommendations for laboratory diagnostics of chronic kidney disease (CKD)?

2020 ◽  
Vol 58 (2) ◽  
pp. 202-212
Author(s):  
Vanja Radišić Biljak ◽  
Lorena Honović ◽  
Jasminka Matica ◽  
Branka Krešić ◽  
Sanela Šimić Vojak ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Serum Creatinine ◽  
Implementation Process ◽  
Substantial Improvement ◽  
Initial Assessment ◽  
Laboratory Diagnostics ◽  
Urine Albumin ◽  
Creatinine Measurement ◽  
Serum Creatinine Measurement

AbstractBackgroundIn 2014, the Joint Croatian Working Group (JCWG) for laboratory diagnostic of chronic kidney disease (CKD) conducted a survey across medical-biochemistry laboratories which demonstrated a large heterogeneity in this area of laboratory medicine. To ensure the tools for the standardization process, in 2017 the JCWG-CKD published the first Croatian recommendations for laboratory diagnostics of CKD. To assess the implementation process, we have repeated a survey to explore how well laboratories adhere to the recommendations.MethodsAn invitation to the survey was sent to all Croatian medical-biochemistry laboratories (n = 196). The questionnaire was designed in a form of 19 questions and statements, with possible multiple answers.ResultsThe response rate was 98/196 (50.0%). The predominant method for serum creatinine measurement was the standardized compensated Jaffe method (79.2%). There was substantial decrease in the number of laboratories which measure creatinine with the non-standardized uncompensated Jaffe method, compared with the initial 2014 assessment; 7% vs. 40%, respectively. The number of the laboratories that did not report estimated glomerular filtration rate (eGFR) values decreased almost by half compared to the initial data (37.6% vs. 74.4%). However, compared to the 2014 initial assessment, a similar number of laboratories (54/98 vs. 58/80) did not measure urine albumin or protein.ConclusionsThe collected data showed a substantial improvement in the standardization of the serum creatinine measurement, as well as in the reporting of eGFR. However, albuminuria or proteinuria assessment is still not implemented nationwide, mainly in primary health care laboratories. This demonstrates the importance of promoting and monitoring implementation of guidelines after publication.

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