A Comprehensive Review of Potential Warfarin-Fruit Interactions

2014 ◽  
Vol 28 (6) ◽  
pp. 561-571 ◽  
Author(s):  
Daryl A. Norwood ◽  
Crystal K. Parke ◽  
Leonard R. Rappa
Keyword(s):  
Clinical Trials ◽  
Grapefruit Juice ◽  
Fruit Juice ◽  
Case Reports ◽  
Scientific Evidence ◽  
International Normalized Ratio ◽  
Pomegranate Juice ◽  
Controlled Clinical Trials ◽  
Dietary History ◽  
Search Terms

Purpose: The aim of this review is to discuss possible interactions that may occur between warfarin and fruit products. Methods: A literature search was conducted using the search terms: “warfarin (Coumadin®) and fruit interactions, warfarin and fruit, warfarin and fruit juice, case reports and clinical trials”. Results: A total of 23 citations (15 case reports and 7 controlled clinical trials) were reviewed. The majority of cases involved cranberry products, while pomegranate juice, avocado, grapefruit juice, mango, and papain were also implicated in reports of suspected warfarin-fruit interactions. Cranberry juice was also the most frequently studied fruit product. Other fruit products evaluated with warfarin in controlled clinical trials were cranberry concentrate and grapefruit juice. Conclusion: Although a number of case reports have been published that suggest warfarin has the potential to interact with several fruit products, it is difficult to determine their relevance, as scientific evidence is scarce. Until further information is available, clinicians may want to encourage patients to consume cranberry products and grapefruit juice in small to moderate quantities and to inquire about the recent consumption of mangos, pomegranate juice, and avocados when taking a dietary history or when assessing possible causes for international normalized ratio (INR) instability.

The Need for Routine Bleomycin Test Dosing in the 21st Century

2005 ◽  
Vol 39 (11) ◽  
pp. 1897-1902 ◽  
Author(s):  
Masha SH Lam
Keyword(s):  
Clinical Trials ◽  
English Language ◽  
Case Reports ◽  
Mail Survey ◽  
Signs And Symptoms ◽  
Test Dose ◽  
Host Cells ◽  
High Grade Fever ◽  
Search Terms ◽  
E Mail

OBJECTIVE To review the clinical evidence for routine use of bleomycin test dosing. DATA SOURCES English-language review articles, references from retrieved articles, case reports, and clinical trials were identified from a MEDLINE literature search (1966–July 2005). Key search terms included bleomycin, test dose, anaphylactic reactions, and hypersensitivity. Information from an unpublished E-mail survey, the manufacturer, and the Internet was also used. DATA SYNTHESIS Early clinical trials and isolated case reports suggest that bleomycin-induced acute hypersensitivity reactions occur in 1% of patients with lymphoma and <0.5% of those with solid tumors. The reactions are mainly characterized by high-grade fever, chills, hypotension, and in a few cases, cardiovascular collapse, which can lead to death. The exact mechanism of these reactions is unclear, but is thought to be related to the release of endogenous pyrogens from the host cells. Evidence does not suggest any correlation between doses and the onset or severity of the reactions. Supportive care, including hydration, steroids, antipyretics, and antihistamines, may resolve the symptoms. However, it may not completely prevent recurrences. CONCLUSIONS The incidence of acute hypersensitivity or hyperpyrexic reactions associated with bleomycin is very low, but the reaction is potentially fatal. Clinicians should monitor their patients for any signs and symptoms of acute hyperpyrexic reactions during bleomycin administration. Since the onset of the reactions can occur with any dose of bleomycin and at any time, routine test dosing does not seem to predict when drug reactions may occur.

Hypnosis in the Treatment of Depression: Research and Theory

1986 ◽  
Vol 58 (3) ◽  
pp. 923-929 ◽  
Author(s):  
Joseph Deltito ◽  
Lee Baer
Keyword(s):  
Clinical Trials ◽  
Cognitive Therapy ◽  
Case Reports ◽  
Unipolar Depression ◽  
Controlled Clinical Trials ◽  
Treatment Of Depression

The literature contains several case reports demonstrating the successful use of hypnosis in nonpsychotic, unipolar depression; controlled studies however are lacking. In an attempt to substantiate theoretically the anecdotal literature on hypnotic treatments of depression, we advance the following theory: hypnotic treatment can be viewed as both an antianxiety technique and as a facilitator of restructuring nihilistic cognitions in depression. Hypnosis, both theoretically and anecdotally, appears to facilitate the process of cognitive therapy. The importance of moderate to high hypnotic ability of patients is commented on, and the need for controlled clinical trials is noted.

So Much Writing, So Little Science: A Review of 37 Years of Literature on Edetate Sodium Chelation Therapy

1993 ◽  
Vol 27 (12) ◽  
pp. 1504-1509 ◽  
Author(s):  
Michael T. Grier ◽  
David G. Meyers
Keyword(s):  
Clinical Trials ◽  
Clinical Practice ◽  
Literature Search ◽  
Chelation Therapy ◽  
Case Reports ◽  
Scientific Evidence ◽  
Case Series ◽  
Mechanisms Of Action ◽  
Tetraacetic Acid ◽  
Safety And Efficacy

OBJECTIVE: To determine the safety and efficacy of edetate sodium (ethylenediamine tetraacetic acid; EDTA) chelation therapy for atherosclerosis. METHODS: Literature search using MEDLINE, encompassing 1966 through May 1993. Further references were obtained from articles and books, and from citations obtained from the American Academy of Medical Preventics. RESULTS: 16 case reports or case series, 2 longitudinal studies, and 3 clinical trials were reviewed, along with testimonials cited in 19 books. CONCLUSIONS: Little valid scientific evidence is available. Although the postulated mechanisms of action for EDTA are biologically plausible and EDTA appears to be safe, it has not been proven effective. Indeed, the best evidence shows it to be ineffective. Therefore, EDTA chelation therapy should not be used in clinical practice to treat atherosclerosis.

Possible Interaction of Indomethacin and Warfarin

1978 ◽  
Vol 12 (10) ◽  
pp. 580-581 ◽  
Author(s):  
Timothy H. Self ◽  
Mark S. Soloway ◽  
Don Vaughn
Keyword(s):  
Clinical Trials ◽  
Case Report ◽  
Prothrombin Time ◽  
Case Reports ◽  
Controlled Clinical Trials ◽  
Low Incidence

A case report of a possible interaction between indomethacin and warfarin is presented. The effect of warfarin on the prothrombin time (PT) was enhanced while indomethacin was given concurrently. Substitution of Ibuprofen for indomethacin resulted in the desired control of the prothrombin time. Based on the results of controlled clinical trials and on the rarity of case reports, there is probably an extremely low incidence of enhancement of warfarin-induced hypoprothrombinemia by indomethacin.

Challenges to Conducting Multicenter Clinical Research

2008 ◽  
Vol 19 (2) ◽  
pp. 164-169
Author(s):  
Sharon Y. Irving ◽  
Martha A.Q. Curley
Keyword(s):  
Clinical Trials ◽  
Clinical Research ◽  
Quantitative Research ◽  
Scientific Evidence ◽  
Internal Validity ◽  
Controlled Clinical Trials ◽  
Level Of Evidence ◽  
Randomized Controlled Clinical Trials ◽  
Randomized Controlled ◽  
Multicenter Clinical Trials

Nursing care provided to patients and their families should be based on strong scientific evidence. In the quantitative research paradigm, the highest level of evidence is derived from conclusive randomized controlled clinical trials. Multicenter clinical research allows the accrual of sufficient numbers of diverse participants in a shorter period of time and improves the generalizability of the study findings. Clinical research is inherently complex; the complexity exponentially increases when conducting multicenter clinical trials. Investigators are challenged to maintain the internal validity of the study and the sustained commitment and collaboration of numerous disciplines over the study period. This article presents 10 essential points to consider when conducting multicenter clinical research.

scholarly journals Prophylactic removal of unerupted asymptomatic third molars: is it justifiable?

2017 ◽  
Vol 74 (1) ◽  
pp. 62
Author(s):  
Marlus Da Silva Pedrosa ◽  
Evelyn Bianca Soares Silva ◽  
Thais Oliveira Cordeiro ◽  
Luiz Gustavo Fernandes Lima Oliveira ◽  
Rodrigo Richard Da Silveira ◽  
...  
Keyword(s):  
Web Of Science ◽  
Case Reports ◽  
Scientific Evidence ◽  
Original Research ◽  
Decision Making Process ◽  
Third Molars ◽  
Case Evaluation ◽  
Search Terms ◽  
Associated Lesions ◽  
Molar Third

Objective: to review the literature currently available on the evidence that does or does not justify the prophylactic extraction of unerupted asymptomatic third molars. Material and Methods: the electronic databases PubMed, Capes Periodicals, Web of Science and Scopus were searched from November to December 2016 by two authors, simultaneously, using as search terms: Terceiro Molar/Molar, Third AND Extração Profilática/Prophylatic Removal OR Prophylatic Extraction. We included articles from original research and clinical trials published in English and Portuguese. No limits were applied to the date of publication. Review articles and clinical case reports were removed. Results: we identified 13 studies that addressed, at some aspect, the prophylactic removal of unerupted asymptomatic third molars. The results of this literature review which alluded to the potential for the formation of pathological alterations in asymptomatic third molars are conflicting; While some justifies the prophylactic procedure based on the possible formation of associated lesions, other scientific evidence does not support such practice. Conclusion: in view of the conflicting viewpoints found in the literature, the prophylactic removal of asymptomatic third molars requires case-by-case evaluation of each patient, and the decision-making process, regarding the retention versus the prophylactic removal of these teeth should be based on scientific evidence combined with the clinical experience of the professional.

scholarly journals Nutraceuticals and nutritional supplements for the treatment of bipolar disorder: protocol for a systematic review

BMJ Open ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. e025640 ◽  
Author(s):  
Melanie M Ashton ◽  
Michael Berk ◽  
Chee H Ng ◽  
Malcolm Hopwood ◽  
Bianca Kavanagh ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bipolar Disorder ◽  
Clinical Trials ◽  
Research Question ◽  
Risk Of Bias ◽  
Published Data ◽  
Cochrane Central Register ◽  
Controlled Clinical Trials ◽  
Double Blind ◽  
Search Terms

IntroductionFirst line pharmacological treatments for bipolar disorder (BD) can leave shortfalls in recovery leading to patients seeking alternative and adjunctive treatments such as nutraceuticals. This protocol for a systematic review and proposed meta-analysis aims to answer the research question: in patients with BD, how does use of nutraceutical treatments compare with placebo in reducing depressive and mania symptoms?Methods and analysisClinical trials will be identified through database searches using PubMed via PubMed, EMBASE via embase.com, Cochrane Central Register of Controlled Clinical Trials (CENTRAL) via cochranelibrary.com and CINAHL Complete via EBSCO. Search terms for BD and specific nutraceuticals (75 total search terms) will be used. Double-blind, randomised, controlled, clinical trials of adults with BD will be included in the review. Risk of bias will be assessed using the Cochrane Collaboration’s tool for assessing risk of bias in randomised trials.Ethics and disseminationThis review will only look at published data (already reviewed for ethical compliance); therefore, ethical approval is not required. We aim to publish the systematic review in a peer-reviewed journal and present at conferences.PROSPERO registration numberCRD42019100745.

scholarly journals A Review of Acupuncture Treatment for Infertility

2021 ◽  
Vol 38 (4) ◽  
pp. 257-264
Author(s):  
Hea sun Chun ◽  
Ho-Sueb Song
Keyword(s):  
Clinical Trials ◽  
Clinical Study ◽  
Animal Studies ◽  
Polycystic Ovarian Syndrome ◽  
Acupuncture Treatment ◽  
Case Reports ◽  
Infertility Treatment ◽  
Control Group ◽  
Search Terms ◽  
Ovarian Syndrome

The purpose of this study was to analyze acupuncture treatment methods and acupoint used to treat infertility in the last decade. The data were retrieved from 2010.1 to 2021.8. using national and international electronic databases (PubMed, EMBASE, OASIS, NDSL, and KISS). “Infertility,” “sterility,” “acupuncture,” “electroacupuncture,” “bloodletting,” “pharmacopuncture,” were used as search terms. All studies were mainly concerned with acupuncture treatment of infertility, but the studies which were not related included; (1) infertility or acupuncture treatment; (2) animal studies; (3) review/meta/protocol or clinical study; comparative studies and case reports which were excluded from this review. Only clinical trials for acupuncture treatment of infertility were included in this review (n = 18). For infertility treatment studies using acupuncture, polycystic ovarian syndrome was the main cause of infertility, the most common acupoint used was CV4, CV3, CV6, SP6, BL23, and the treatment effect significantly improved in the group receiving acupuncture treatment compared with the control group, or the group taking Western medicine alone. In some studies, the group using acupuncture treatment did not show side effects. Acupuncture is an effective treatment for infertility.

scholarly journals Impact of Psoriasis and Hidradenitis Suppurativa in Pregnancy, a Systematic Review

2021 ◽  
Vol 10 (24) ◽  
pp. 5894
Author(s):  
Maria-Angeles Ferrer-Alcala ◽  
Manuel Sánchez-Díaz ◽  
Salvador Arias-Santiago ◽  
Alejandro Molina-Leyva
Keyword(s):  
Systematic Review ◽  
Adverse Events ◽  
Hidradenitis Suppurativa ◽  
Skin Diseases ◽  
Case Reports ◽  
Scientific Evidence ◽  
Acne Inversa ◽  
Inflammatory Skin Diseases ◽  
Search Terms ◽  
The Impact

Psoriasis and hidradenitis suppurativa (HS) are chronic inflammatory skin diseases that frequently develop in young women. The aim of this study is to evaluate how hidradenitis suppurativa and psoriasis impact women desiring to conceive, and their influence on fertility and gestation. A systematic review of articles dating from January 2015 to April 2021 was performed using the Scopus (Elsevier) database. The search terms were (psoriasis and (birth or pregnancy or fertility)) and ((hidradenitis suppurativa or acne inversa) and (birth or pregnancy or fertility)). The search was limited to human data. Systematic reviews, case reports, clinical practice guidelines, expert consensus and conference papers were excluded. The impact of HS on pregnancy includes an impaired desire for pregnancy, a decrease in fertility, the worsening of the disease during pregnancy and potential adverse events during pregnancy. Moreover, the pregnancy might imply a change on the treatment of HS. The impact of psoriasis on pregnancy includes a decrease in fertility, potential adverse events during pregnancy and an unpredictable evolution of the disease. Moreover, the pregnancy might imply a change on the treatment of psoriasis, although biologic therapies do not appear to increase the risk of adverse events. In conclusion, both HS and psoriasis have an impact on pregnancy. A decrease of fertility has been reported. Moreover, both diseases have an unpredictable evolution during pregnancy. Pregnant women who are under biologic therapy do not seem to have a higher rate of adverse events. Treatment of both conditions is usually halted during pregnancy since scientific evidence about their safety is not conclusive, or teratogenic risk has been proven.

scholarly journals The Skin in Celiac Disease Patients: The Other Side of the Coin

Medicina ◽  
2019 ◽  
Vol 55 (9) ◽  
pp. 578 ◽  
Author(s):  
Ludovico Abenavoli ◽  
Stefano Dastoli ◽  
Luigi Bennardo ◽  
Luigi Boccuto ◽  
Maria Passante ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Celiac Disease ◽  
Skin Diseases ◽  
Case Reports ◽  
Case Series ◽  
The Other ◽  
Gluten Free ◽  
Controlled Clinical Trials ◽  
Cutaneous Manifestations ◽  
Small Intestinal

Celiac disease (CD) is an autoimmune enteropathy that primarily affects the small intestine and is characterized by atrophy of intestinal villi. The manifestations of the disease improve following a gluten-free diet (GFD). CD is associated with various extra-intestinal diseases. Several skin manifestations are described in CD patients. The present paper reviews all CD-associated skin diseases reported in the literature and tries to analyze the pathogenic mechanisms possibly involved in these associations. Different hypotheses have been proposed to explain the possible mechanisms involved in every association between CD and cutaneous manifestations. An abnormal small intestinal permeability seems to be implicated in various dermatological manifestations. However, most of the associations between CD and cutaneous diseases is based on case reports and case series and a few controlled studies. To better assess the real involvement of the cutaneous district in CD patients, large multicentric controlled clinical trials are required.

Sign in / Sign up

Export Citation Format

Share Document