scholarly journals Sex Differences in Clinical and Functional Outcomes among Patients Treated in an Early Intervention Service for Psychotic Disorders: An Observational Study

2019 ◽  
pp. 070674371985406
Author(s):  
Manish Dama ◽  
Franz Veru ◽  
Norbert Schmitz ◽  
Jai Shah ◽  
Srividya Iyer ◽  
...  
Keyword(s):  
Sex Differences ◽  
Early Intervention ◽  
Observational Study ◽  
Functional Outcomes ◽  
Psychotic Disorders ◽  
Early Intervention Service ◽  
Intervention Service

scholarly journals Neurobiology Youth Follow-up Study: protocol to establish a longitudinal and prospective research database using multimodal assessments for current and past mental health treatment-seeking young people within an early intervention service

BMJ Open ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. e044731
Author(s):  
Alissa Nichles ◽  
Natalia Zmicerevska ◽  
Yun Ju Christine Song ◽  
Chloe Wilson ◽  
Catherine McHugh ◽  
...  
Keyword(s):  
Mental Health ◽  
Early Intervention ◽  
Study Protocol ◽  
Functional Outcomes ◽  
Clinical Stage ◽  
Early Intervention Service ◽  
Follow Up Study ◽  
Intervention Service ◽  
Occupational Function

IntroductionApproximately 75% of major mental illness occurs before the age of 25 years. Despite this, our capacity to provide effective, early and personalised interventions is limited by insufficient evidence for characterising early-stage, and less specific, presentations of major mental disorders in youth populations. This article describes the protocol for setting up a large-scale database that will collect longitudinal, prospective data that incorporate clinical, social and occupational function, neuropsychological, circadian, metabolic, family history and genetic metrics. By collecting data in a research-purposed, standardised manner, the ‘Neurobiology Youth Follow-up Study’ should improve identification, characterisation and profiling of youth attending mental healthcare, to better inform diagnosis and treatment at critical time points. The overall goal is enhanced long-term clinical and functional outcomes.Methods and analysisThis longitudinal clinical cohort study will invite participation from youth (12–30 years) who seek help for mental health-related issues at an early intervention service (headspace Camperdown) and linked services. Participants will be prospectively tracked over 3 years with a series of standardised multimodal assessments at baseline, 6, 12, 24 and 36 months. Evaluations will include: (1) clinician-administered and self-report assessments determining clinical stage, pathophysiological pathways to illness, diagnosis, symptomatology, social and occupational function; (2) neuropsychological profile; (3) sleep–wake patterns and circadian rhythms; (4) metabolic markers and (5) genetics. These data will be used to: (1) model the impact of demographic, phenomenological and treatment variables, on clinical and functional outcomes; (2) map neurobiological profiles and changes onto a transdiagnostic clinical stage and pathophysiological mechanisms framework.Ethics and disseminationThis study protocol has been approved by the Human Research Ethics Committee of the Sydney Local Health District (2020/ETH01272, protocol V.1.3, 14 October 2020). Research findings will be disseminated through peer-reviewed journals and presentations at scientific conferences and to user and advocacy groups. Participant data will be de-identified.

Mode of Entry to an Early Intervention Service for Psychotic Disorders: Determinants and Impact on Outcome

2013 ◽  
Vol 64 (11) ◽  
pp. 1166-1169 ◽  
Author(s):  
Shamira Pira ◽  
Georges Durr ◽  
Nicole Pawliuk ◽  
Ridha Joober ◽  
Ashok Malla
Keyword(s):  
Early Intervention ◽  
Psychotic Disorders ◽  
Early Intervention Service ◽  
Mode Of Entry ◽  
Intervention Service

scholarly journals M114. DELUSIONAL CONTENT AT INITIAL PRESENTATION TO A CATCHMENT-BASED EARLY INTERVENTION SERVICE FOR PSYCHOSIS

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S178-S178
Author(s):  
Ann-Catherine Lemonde ◽  
Ridha Joober ◽  
Ashok Malla ◽  
Srividya Iyer ◽  
Martin Lepage ◽  
...  
Keyword(s):  
Early Intervention ◽  
Representative Sample ◽  
Clinical Samples ◽  
First Episode ◽  
Psychotic Episode ◽  
Detailed Knowledge ◽  
Service Users ◽  
Early Intervention Service ◽  
Clinical Variables ◽  
Intervention Service

Abstract Background During a psychotic episode, patients frequently suffer from severe maladaptive beliefs known as delusions. Despite the abundant literature investigating the simple presence or absence of these beliefs, there exists little detailed knowledge regarding their actual content and severity at the onset of illness. Investigating delusions in early clinical samples is critical, because their relatively young, treatment-naïve presentations are less likely to be confounded by the effects of long-term illness or previous interventions. Furthermore, a more detailed view of the association between clinical factors and delusion severity, both globally and per theme, in a larger and more representative sample may improve psychological models and ultimately treatment options. This study reports on delusions during the initiation of indicated treatment for a first episode psychosis (FEP). Methods Data were systematically collected from a sample of 637 service users entering an early intervention service for FEP. The FEP service provides a comprehensive standardized assessment battery with longitudinal follow-up for two years of treatment. The average severity and frequency of each delusional theme at baseline was reported using the Scale for Assessment of Positive Symptoms. Delusional severity, both globally and per theme, was examined across a number of sociodemographic and clinical variables. Results Delusions of a moderate severity or higher were present in the vast majority of individuals experiencing onset of a FEP (94.0%), with persecutory (77.7%), reference (65.5%), and grandiose (40.2%) being the most common themes. Eighty-one percent of service users presented with two or more delusion themes. Persecutory delusions remained consistent in severity across diagnoses, but were more severe with older age of onset (r = .144). No meaningful differences in delusional severity were observed across sex, affective versus non-affective psychosis, or presence/absence of substance abuse or dependence. Global delusion severity was associated with anxiety (r = .205) but not with depression (r = .052), with specific relationships emerging per theme. Delusions commonly referred to as passivity experiences and/or thought alienation, mind reading delusions (r = .242) and delusions of control (r = .247), were related to hallucinatory experiences. We will also examine delusions longitudinally by investigating their relationship to the duration of untreated psychosis and outcomes, along with the stability of delusional content across episodes. Discussion Unlike the more selected samples, confounded treatment effects, and/or varying levels of chronicity seen in previous reports, this community representative sample offers a rare clinical lens into the severity and content of delusions in FEP. While delusional severity remained consistent across certain sociodemographic and clinical variables, this was not always the case. Future work may wish to investigate the evolution of delusions over time, including focusing on specific themes and/or their overlaps, including with smaller samples and in-depth, phenomenologically oriented interviews.

scholarly journals Family‐centred care in early intervention: Examining caregiver perceptions of family‐centred care and early intervention service use intensity

2019 ◽  
Vol 46 (1) ◽  
pp. 1-8
Author(s):  
Beth M. McManus ◽  
Natalie J. Murphy ◽  
Zachary Richardson ◽  
Mary A. Khetani ◽  
Margaret Schenkman ◽  
...  
Keyword(s):  
Early Intervention ◽  
Service Use ◽  
Early Intervention Service ◽  
Intervention Service

Cognitive remediation combined with an early intervention service in first episode psychosis

2014 ◽  
Vol 130 (4) ◽  
pp. 300-310 ◽  
Author(s):  
T. Østergaard Christensen ◽  
L. Vesterager ◽  
G. Krarup ◽  
B. B. Olsen ◽  
M. Melau ◽  
...  
Keyword(s):  
Early Intervention ◽  
Cognitive Remediation ◽  
First Episode Psychosis ◽  
First Episode ◽  
Early Intervention Service ◽  
Intervention Service ◽  
Episode Psychosis
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