Effect of Varying Types of Anti-Arthritic Drugs on TH1 and TH2 Immune Responses in Mice

2005 ◽  
Vol 18 (1) ◽  
pp. 133-144 ◽  
Author(s):  
K. Yamaki ◽  
H. Uchida ◽  
X. Li ◽  
R. Yanagisawa ◽  
H. Takano ◽  
...  
Keyword(s):  
Immune Responses ◽  
Th1 And Th2

THE EFFECT OF SUBACUTE INTOXICATION WITH ETHYLENE CHLOROHYDRIN ON IMMUNE RESPONSES, TH1 AND TH2 LYMPHOCYTE FUNCTION AND CYTOKINE LEVELS IN RATS BLOOD

2017 ◽  
pp. 27-30
Author(s):  
P. F. Zabrodskii ◽  
V. V. Maslyakov ◽  
M. S. Gromov
Keyword(s):  
Immune Responses ◽  
Inflammatory Cytokine ◽  
Albino Rats ◽  
Lymphocyte Function ◽  
Ethylene Chlorohydrin ◽  
Immunoregulatory Cytokines ◽  
Cytokine Levels ◽  
Th1 And Th2 Lymphocytes ◽  
Cellular Immune ◽  
Th1 And Th2

In experiments on outbred albino rats, it was established that subacute intoxication with ethylene chlorohydrin (0.2 LD50 daily for 4 days) causes a decrease in Th1 and Th2 lymphocytes function to the same extent, diminishes parameters of humoral and cellular immune responses and the content of immunoregulatory cytokines IFN- , IL-2, IL-4 in blood, increases concentrations of pro-inflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10.

Paclitaxel acts as an adjuvant to promote both Th1 and Th2 immune responses induced by ovalbumin in mice

Vaccine ◽  
2010 ◽  
Vol 28 (27) ◽  
pp. 4402-4410 ◽  
Author(s):  
Lin Yuan ◽  
Lihua Wu ◽  
Jian Chen ◽  
Qiang Wu ◽  
Songhua Hu
Keyword(s):  
Immune Responses ◽  
Th1 And Th2

Effect of the Nonsteroidal Anti-inflammatory Drug Indomethacin on Th1 and Th2 Immune Responses in Mice

2003 ◽  
Vol 92 (8) ◽  
pp. 1723-1729 ◽  
Author(s):  
Kouya Yamaki ◽  
Hiroyuki Uchida ◽  
Yoshiki Harada ◽  
Rie Yanagisawa ◽  
Hirohisa Takano ◽  
...  
Keyword(s):  
Immune Responses ◽  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Th1 And Th2

scholarly journals UVB exposure‐induced systemic modulation of Th1‐ and Th2‐mediated immune responses

Immunology ◽  
1999 ◽  
Vol 97 (3) ◽  
pp. 506-514 ◽  
Author(s):  
Garssen ◽  
Vandebriel ◽  
De Gruijl ◽  
Wolvers ◽  
Van Dijk ◽  
...  
Keyword(s):  
Immune Responses ◽  
Uvb Exposure ◽  
Th1 And Th2

scholarly journals STAT4 is required for the generation of Th1 and Th2, but not Th17 immune responses during monophosphoryl lipid A adjuvant activity

2018 ◽  
Vol 30 (8) ◽  
pp. 385-385
Author(s):  
Sanjay Varikuti ◽  
Steve Oghumu ◽  
Gayathri Natarajan ◽  
Jennifer Kimble ◽  
Rachel H Sperling ◽  
...  
Keyword(s):  
Immune Responses ◽  
Lipid A ◽  
Adjuvant Activity ◽  
Monophosphoryl Lipid A ◽  
Monophosphoryl Lipid ◽  
Th1 And Th2

Suppression of Th1- and Th2-type immune responses in infant mouse spleen after prenatal and postnatal exposure to low-level toluene and peptidoglycan

2009 ◽  
Vol 21 (9) ◽  
pp. 793-802 ◽  
Author(s):  
Shoji Yamamoto ◽  
Tin Tin Win Shwe ◽  
Yasuhiro Yoshida ◽  
Naoki Kunugita ◽  
Keiichi Arashidani ◽  
...  
Keyword(s):  
Immune Responses ◽  
Mouse Spleen ◽  
Postnatal Exposure ◽  
Infant Mouse ◽  
Low Level ◽  
Th1 And Th2

Differential immune responses in mice infected with the tissue-dwelling nematode Trichinella zimbabwensis

2015 ◽  
Vol 90 (5) ◽  
pp. 547-554 ◽  
Author(s):  
W.N. Onkoba ◽  
M.J. Chimbari ◽  
J.M. Kamau ◽  
S. Mukaratirwa
Keyword(s):  
Immune Responses ◽  
Antibody Responses ◽  
Diagnostic Tools ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Infected Control ◽  
Tnf Α ◽  
Infected Control Group ◽  
Tissue Migration ◽  
Th1 And Th2

AbstractTo improve diagnostic tools, immunotherapies and vaccine development for trichinellosis surveillance and control there is a need to understand the host immune responses induced during infection with Trichinella zimbabwensis, a tissue-dwelling nematode. In this study, we sought to determine immune responses induced in mice during T. zimbabwensis infection. The parasite strain used (Code ISS1209) was derived from a naturally infected crocodile (Crocodylus niloticus) and is the main Trichinella species prevalent in southern Africa. Sixty 6- to 8-week-old female BALB/c mice were randomly assigned to two equal groups: T. zimbabwensis-infected (n= 30) and the non-infected control group (n= 30). Levels of serum tumour necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), interleukin-4 (IL-4) as well as parasite-specific IgM, IgG, IgG1, IgG2a, IgG2b and IgG3 antibody responses were determined using enzyme-linked immunosorbent assay (ELISA). The cytokines and antibodies provided information on T-helper 1 (Th1)- and Th2-type, T-regulatory and antibody responses. Results showed that during the intestinal stage of infection, higher levels of parasite-specific IgM, IgG, IgG1 (P <  0.05) and IL-10 and TNF-α (P <  0.001) were observed in the Trichinella-infected group compared with the non-infected control group. In the parasite establishment and tissue migration phases, levels of IgG1 and IgG3 were elevated (P <  0.001), while those of IgM (P <  0.01) declined on days 21 and 35 post infection (pi) compared to the enteric phase. Our findings show that distinct differences in Th1- and Th2-type and T-regulatory responses are induced during the intestinal, tissue migration and larval establishment stages of T. zimbabwensis infection.

C57Bl/6 and BALB/c mice do not represent default Th1 and Th2 strains in allergen-driven immune responses

2005 ◽  
Vol 115 (2) ◽  
pp. S258 ◽  
Author(s):  
K.T. HayGlass ◽  
B. Nashed ◽  
S. Haile ◽  
A.J. Marshall ◽  
W. Thomas
Keyword(s):  
Immune Responses ◽  
Th1 And Th2
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