scholarly journals Blood damage in ventricular assist devices

2019 ◽  
Vol 42 (3) ◽  
pp. 111-112
Author(s):  
Michael Simmonds ◽  
Bente Thamsen ◽  
Ulrich Kertzscher
Keyword(s):  
Ventricular Assist Devices ◽  
Ventricular Assist ◽  
Assist Devices ◽  
Blood Damage

scholarly journals A Quantitative Comparison of Mechanical Blood Damage Parameters in Rotary Ventricular Assist Devices: Shear Stress, Exposure Time and Hemolysis Index

2012 ◽  
Vol 134 (8) ◽  
Author(s):  
Katharine H. Fraser ◽  
Tao Zhang ◽  
M. Ertan Taskin ◽  
Bartley P. Griffith ◽  
Zhongjun J. Wu
Keyword(s):  
Shear Stress ◽  
Platelet Activation ◽  
Exposure Time ◽  
Ventricular Assist Devices ◽  
Shear Stresses ◽  
Residence Times ◽  
Stress Exposure ◽  
Ventricular Assist ◽  
Assist Devices ◽  
Blood Damage

Ventricular assist devices (VADs) have already helped many patients with heart failure but have the potential to assist more patients if current problems with blood damage (hemolysis, platelet activation, thrombosis and emboli, and destruction of the von Willebrand factor (vWf)) can be eliminated. A step towards this goal is better understanding of the relationships between shear stress, exposure time, and blood damage and, from there, the development of numerical models for the different types of blood damage to enable the design of improved VADs. In this study, computational fluid dynamics (CFD) was used to calculate the hemodynamics in three clinical VADs and two investigational VADs and the shear stress, residence time, and hemolysis were investigated. A new scalar transport model for hemolysis was developed. The results were compared with in vitro measurements of the pressure head in each VAD and the hemolysis index in two VADs. A comparative analysis of the blood damage related fluid dynamic parameters and hemolysis index was performed among the VADs. Compared to the centrifugal VADs, the axial VADs had: higher mean scalar shear stress (sss); a wider range of sss, with larger maxima and larger percentage volumes at both low and high sss; and longer residence times at very high sss. The hemolysis predictions were in agreement with the experiments and showed that the axial VADs had a higher hemolysis index. The increased hemolysis in axial VADs compared to centrifugal VADs is a direct result of their higher shear stresses and longer residence times. Since platelet activation and destruction of the vWf also require high shear stresses, the flow conditions inside axial VADs are likely to result in more of these types of blood damage compared with centrifugal VADs.

Interactive Blood Damage Analysis for Ventricular Assist Devices

2008 ◽  
Vol 14 (6) ◽  
pp. 1515-1522 ◽  
Author(s):  
B. Hentschel ◽  
I. Tedjo ◽  
M. Probst ◽  
M. Wolter ◽  
M. Behr ◽  
...  
Keyword(s):  
Ventricular Assist Devices ◽  
Damage Analysis ◽  
Ventricular Assist ◽  
Assist Devices ◽  
Blood Damage

scholarly journals Validation of a Miniaturized Test Loop for the Assessment of Human Blood Damage by Continuous-Flow Left-Ventricular Assist Devices

2021 ◽  
Author(s):  
Eva Woelke ◽  
Ilona Mager ◽  
Thomas Schmitz-Rode ◽  
Ulrich Steinseifer ◽  
Johanna C. Clauser
Keyword(s):  
Human Blood ◽  
Left Ventricular ◽  
Ventricular Assist Devices ◽  
Standardized Assessment ◽  
Left Ventricular Assist Devices ◽  
Ventricular Assist ◽  
Assist Devices ◽  
Blood Damage ◽  
Test Loop ◽  
Left Ventricular Assist

AbstractDespite improved hemocompatibility of left-ventricular assist devices (LVADs), assessment of blood damage remains mandatory in preclinical testing as standardized by ASTM-F1841. The most relevant test fluid is fresh, non-pooled human blood, but the limited volume of a standard donation requires significantly smaller loops than those commonly used with animal blood. In a recent study with porcine blood, we verified a miniaturized test loop with only 160 mL for the ASTM-conform paired testing of at least two LVADs and a static reference. Here, we validated this mini test loop for standardized assessment of blood damage with one 450-mL single donation of fresh human blood. Blood damage was assessed for HeartMate 3 and BPX-80 in 9 experiments with heparinized human blood for 6 hours. We analyzed plasma free hemoglobin, von Willebrand factor (vWF) concentration and collagen-binding functionality and calculated indices of hemolysis and vWF-ratios. Overall, we observed less blood damage compared to our previous study; however, the differences in mean indices of hemolysis and in mean normalized vWF-ratio between BPX-80 and HeartMate 3 were consistent for human blood. Thus, our mini test loop proved to be valid for preclinical standardized assessment of blood damage with only 450 mL of fresh human blood.

scholarly journals Blood Damage in Ventricular Assist Devices

2016 ◽  
Vol 39 (4) ◽  
pp. 147-149 ◽  
Author(s):  
Bente Thamsen ◽  
Marcus Granegger ◽  
Ulrich Kertzscher
Keyword(s):  
Ventricular Assist Devices ◽  
Ventricular Assist ◽  
Assist Devices ◽  
Blood Damage
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