scholarly journals The biological clock in cluster headache: A review and hypothesis

Cephalalgia ◽  
2019 ◽  
Vol 39 (14) ◽  
pp. 1855-1866 ◽  
Author(s):  
Willemijn C Naber ◽  
Rolf Fronczek ◽  
Joost Haan ◽  
Patty Doesborg ◽  
Christopher S Colwell ◽  
...  
Keyword(s):  
Cluster Headache ◽  
Sleep Stage ◽  
Seasonal Pattern ◽  
Biological Clock ◽  
Clear Correlation ◽  
Cluster Headache Attack ◽  
Autonomic Reflex ◽  
Role Of Light ◽  
Light Sleep

Objective To review and discuss the putative role of light, sleep, and the biological clock in cluster headache. Discussion Cluster headache attacks are believed to be modulated in the hypothalamus; moreover, the severe pain and typical autonomic cranial features associated with cluster headache are caused by abnormal activity of the trigeminal-autonomic reflex. The temporal pattern of cluster headache attacks suggests involvement of the biological clock, and the seasonal pattern is influenced by the number of daylight hours. Although sleep is often reported as a trigger for cluster headache attacks, to date no clear correlation has been established between these attacks and sleep stage. Conclusions We hypothesize that light, sleep, and the biological clock can change the brain’s state, thereby lowering the threshold for activating the trigeminal-autonomic reflex, resulting in a cluster headache attack. Understanding the mechanisms that contribute to the daily and seasonal fluctuations in cluster headache attacks may provide new therapeutic targets.

scholarly journals Chronobiological features of primary headaches and the role of melatonin in the regulation of biological rhythms

2019 ◽  
pp. 33-38
Author(s):  
E. M. Evdokimova ◽  
M. G. Poluektov ◽  
G. R. Tabeyeva
Keyword(s):  
Circadian Rhythm ◽  
Cluster Headache ◽  
Suprachiasmatic Nucleus ◽  
Seasonal Pattern ◽  
Biological Rhythms ◽  
Primary Headaches ◽  
Melatonin Secretion ◽  
Clinical Observations

Frequency is considered as a key sign of the course of some forms of primary headaches (PH). One of the most prominent representatives is the hypnical and cluster headache, which predetermined their name. Clinical observations demonstrate a clear circadian rhythm and seasonal pattern of cluster headache (CH) and migraine (M) attacks. In accordance with modern concepts, the phenomenon of the periodicity of painful episodes of a number of forms of primary headaches is associated with dysfunction of the suprachiasmatic nucleus of the hypothalamus, the main pacemaker of biological rhythms. The connection of PH with chronopathology is confirmed by revealing the disturbances of melatonin secretion in CH and M. Melatonin has proven to be effective in treatment of these PH.

Efficacy of galcanezumab in patients with episodic cluster headaches and a history of preventive treatment failure

2021 ◽  
Vol 4 ◽  
pp. 251581632110156
Author(s):  
Brian Plato ◽  
J Scott Andrews ◽  
Mallikarjuna Rettiganti ◽  
Antje Tockhorn-Heidenreich ◽  
Jennifer Bardos ◽  
...  
Keyword(s):  
Cluster Headache ◽  
Treatment Failure ◽  
Preventive Treatment ◽  
Mean Difference ◽  
Least Square ◽  
Double Blind Study ◽  
Double Blind ◽  
Cluster Headache Attack ◽  
Episodic Cluster Headache ◽  
History Of

Objective: The efficacy of galcanezumab was evaluated in patients with episodic cluster headache and history of preventive treatment failure. Methods: In the randomized, 8-week, double-blind study (CGAL), patients with episodic cluster headache received once-monthly subcutaneous injections of galcanezumab 300 mg or placebo. Patients who completed CGAL and enrolled in an open-label study were queried for preventive treatment history. In a subset of patients with a known history of failure of verapamil or any other prior preventive treatment, a post hoc analysis of least square mean change from baseline in weekly cluster headache attack frequency across Weeks 1 to 3 was assessed. Results: Fifteen patients provided data for known history of prior preventive treatment failure (6 placebo, 9 galcanezumab), of whom 11 failed verapamil. The mean reduction in the weekly frequency of cluster headache attacks was greater with galcanezumab compared to placebo among patients with prior preventive treatment failure (8.2 versus 2.4); mean difference 5.8 (95% confidence interval [CI] 2.0, 13.6) and among patients with verapamil failure (10.1 versus 1.6); mean difference 8.5 (95% CI 0.4, 16.7). Conclusion: In this exploratory analysis of patients with a known history of prior preventive treatment failures, treatment with galcanezumab resulted in greater mean reductions in weekly cluster headache attacks compared with placebo. ClinicalTrials.gov: NCT02397473 (I5Q-MC-CGAL) NCT02797951 (I5Q-MC-CGAR)

scholarly journals Assessing the Role of Light Absorption in Laser Lithotripsy by Isotopic Substitution of Kidney Stone Materials

2020 ◽  
Vol 6 (9) ◽  
pp. 5274-5280
Author(s):  
Sorout Shalini ◽  
Derek S. Frank ◽  
Ali H. Aldoukhi ◽  
Sami E. Majdalany ◽  
William W. Roberts ◽  
...  
Keyword(s):  
Light Absorption ◽  
Kidney Stone ◽  
Laser Lithotripsy ◽  
Isotopic Substitution ◽  
Stone Materials ◽  
Role Of Light

Role of Light and Medium Composition on Growth and Valepotriate Contents in Valeriana glechomifolia Whole Plant Liquid Cultures

2006 ◽  
Vol 86 (2) ◽  
pp. 211-218 ◽  
Author(s):  
Denise Russowski ◽  
Natasha Maurmann ◽  
Sandra Beatriz Rech ◽  
Arthur Germano Fett-Neto
Keyword(s):  
Medium Composition ◽  
Liquid Cultures ◽  
Whole Plant ◽  
Role Of Light

Studies of Platelet Monoamine Oxidase Activity during an Acute Cluster Headache Attack.

Cephalalgia ◽  
1991 ◽  
Vol 11 (11_suppl) ◽  
pp. 254-255 ◽  
Author(s):  
Aron D. Mosnaim ◽  
Shankar Huprikar ◽  
Marion E. Wolf ◽  
Frederick Freitag ◽  
Seymour Diamond
Keyword(s):  
Monoamine Oxidase ◽  
Cluster Headache ◽  
Oxidase Activity ◽  
Monoamine Oxidase Activity ◽  
Headache Attack ◽  
Cluster Headache Attack ◽  
Platelet Monoamine Oxidase

Role of light-induced scattering in the optical limitation of laser radiation on the basis of fullerene-containing media

2001 ◽  
Vol 90 (2) ◽  
pp. 292-301 ◽  
Author(s):  
I. M. Belousova ◽  
V. A. Grigor’ev ◽  
O. B. Danilov ◽  
A. G. Kalintsev ◽  
A. V. Kris’ko ◽  
...  
Keyword(s):  
Laser Radiation ◽  
Optical Limitation ◽  
Role Of Light

Role of nitric oxide in cluster headache

1999 ◽  
Vol 20 (S1) ◽  
pp. S25-S27 ◽  
Author(s):  
D. D'Amico ◽  
M. Leone ◽  
A. Ferraris ◽  
A. Catania ◽  
A. Carlin ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cluster Headache

Hypothalamic Activation in Trigeminal Autonomic Cephalgia: Functional Imaging of an Atypical Case

Cephalalgia ◽  
2004 ◽  
Vol 24 (9) ◽  
pp. 753-757 ◽  
Author(s):  
T Sprenger ◽  
M Valet ◽  
M Hammes ◽  
P Erhard ◽  
A Berthele ◽  
...  
Keyword(s):  
Cluster Headache ◽  
Paroxysmal Hemicrania ◽  
Cerebral Activation ◽  
Atypical Case ◽  
Clear Cut ◽  
Oxygen Administration ◽  
Autonomic Reflex ◽  
Trigeminal Autonomic Cephalgia ◽  
Hypothalamic Activation

We report headache induced BOLD changes in an atypical case of trigeminal autonomic cephalgia (TAC). A 68-year-old patient was imaged using fMRi during three attacks of a periorbital head-pain with a average duration of 3 min. During the attacks, left sided conjunctival injection, rhinorrhea, lacrimation, facial sweating and hypersalivation were apparent. These attacks were usually partly responsive to oxygen administration but otherwise refractory to any drug. The patient described either attacks with a duration of one minute or less or longer attacks persisting for maximum of 20 min with headaches occurring up to 100 times a day. When considering the symptoms, frequency, duration and therapeutic response of the patient's headache, no clear-cut classification to one of the subtypes of trigeminal autonomic cephalgias (cluster headache, paroxysmal hemicrania, SUNCT) or trigeminal neuralgia was possible. The cerebral activation pattern was similar but not identical to those previously observed in cluster headache and SUNCT with a prominent activation in the hypothalamic grey matter. This case study underlines the conceptual value of the term TAC for the group of headaches focusing around the trigeminal-autonomic reflex. Our results emphasize the importance of the hypothalamus as key region in the pathophysiology of this entity.

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