Human Papillomavirus Vaccination Counseling in Pediatric Training

2016 ◽  
Vol 155 (1) ◽  
pp. 87-93 ◽  
Author(s):  
Sharon H. Gnagi ◽  
Forrest T. Gnagi ◽  
Scott A. Schraff ◽  
Michael L. Hinni

Objective Demonstrate the need for increased education regarding otolaryngology-related manifestations of human papillomavirus (HPV). Highlight a need to incorporate otolaryngology-related manifestations of HPV in vaccine counseling. Study Design Survey. Setting Tertiary care academic children’s hospital. Subjects Pediatric residents, fellows, and staff. Methods An online survey was made available regarding HPV education and vaccination. Results Participants (N = 348) initiated the survey representing 28.4%, 25.6%, and 19.0% postgraduate year 1, 2, and 3 residents, respectively, as well as 17.5% chief residents/fellows and 9.5% attendings. Participants rated their prior education as none or fair regarding recurrent respiratory papillomatosis (63.8%) and oropharyngeal squamous cell carcinoma (68.3%). In contrast, 60.6% and 70.9% rated their education on genital warts and cervical cancer correspondingly as good or excellent. When asked what was routinely discussed during HPV vaccine counseling, 63.3% reported “never” discussing recurrent respiratory papillomatosis and 52.9% “never” discussing oropharyngeal squamous cell carcinoma. A range from 92.7% to 95.5% responded that there was a need for increased education regarding HPV and its role in recurrent respiratory papillomatosis and oropharyngeal squamous cell carcinoma. Conclusions Increased education about HPV and its otolaryngology-related manifestations should be undertaken to increase provider, patient, and parent awareness of recurrent respiratory papillomatosis and oropharyngeal squamous cell carcinoma. We propose that discussing the risks of otolaryngology-related disease be routinely included in HPV vaccination counseling.

Head & Neck ◽  
2017 ◽  
Vol 40 (4) ◽  
pp. 710-721 ◽  
Author(s):  
Omar Mahmoud ◽  
Kim Sung ◽  
Francisco J. Civantos ◽  
Giovanna R. Thomas ◽  
Michael A. Samuels

Head & Neck ◽  
2018 ◽  
Vol 41 (5) ◽  
pp. 1312-1319 ◽  
Author(s):  
Patrik Pipkorn ◽  
Parul Sinha ◽  
Dorina Kallogjeri ◽  
Douglas Adkins ◽  
Wade T. Thorstad ◽  
...  

2019 ◽  
Vol 139 (12) ◽  
pp. 1112-1116 ◽  
Author(s):  
Karoline Dyrberg Stjernstrøm ◽  
Jakob Schmidt Jensen ◽  
Kathrine Kronberg Jakobsen ◽  
Christian Grønhøj ◽  
Christian von Buchwald

2020 ◽  
Author(s):  
Shunsuke Kondo ◽  
Hitoshi Hirakawa ◽  
Taro Ikegami ◽  
Takayuki Uehara ◽  
Shinya Agena ◽  
...  

Abstract Background Despite reports of a link between human papillomavirus (HPV) infection and mechanistic target of rapamycin (mTOR) signaling activation, the role of the mTOR pathway, especially raptor and rictor, in HPV-related head and neck cancer is still unclear. The aim of the present study was to elucidate the role of the mTOR pathway in HPV-related oropharyngeal squamous cell carcinoma (OPSCC). Methods The present study involved two strategies. The first was to investigate the activity of mTOR and mTOR-related complexes in high-risk HPV-positive (UM-SCC47 and CaSki) and HPV-negative (SCC-4 and SAS) cancer cell lines. The second was to elucidate mTOR complex expression in 80 oropharyngeal cancer tissues and to examine the relationship between mTOR complex expression and survival in patients with OPSCC. Results The UM-SCC47 and CaSki cell lines showed high gene and protein expression of raptor. They also exhibited G1/S and G2/M phase cell cycle arrest following 24 h incubation with 6 μM temsirolimus, a rapamycin analog, and temsirolimus administration inhibited their growth. HPV-related OPSCC samples showed high gene expression of raptor and rictor compared with HPV-unrelated OPSCC. In addition, HPV-related OPSCC patients with high raptor and rictor expression tended to have a worse prognosis than those with low or medium expression. Conclusions These results suggest that raptor has an important role in HPV-related OPSCC and that temsirolimus is a potential therapeutic agent for patients with HPV-related OPSCC. This is the first report to reveal overexpression of raptor and rictor in HPV-related OPSCC.


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