Oncologic and Functional Outcomes of Partial Laryngeal Surgery for Intermediate-Stage Laryngeal Cancer

2012 ◽  
Vol 148 (2) ◽  
pp. 235-242 ◽  
Author(s):  
Emiro Caicedo-Granados ◽  
Daniel M. Beswick ◽  
Apostolos Christopoulos ◽  
Diana E. Cunningham ◽  
Ali Razfar ◽  
...  
Keyword(s):  
Laryngeal Cancer ◽  
Functional Outcomes ◽  
Intermediate Stage ◽  
Laryngeal Surgery

Impact of Time to Diagnosis and Treatment in Head and Neck Cancer: A Systematic Review

2020 ◽  
Vol 162 (4) ◽  
pp. 446-457 ◽  
Author(s):  
Henrieke W. Schutte ◽  
Floris Heutink ◽  
David J. Wellenstein ◽  
Guido B. van den Broek ◽  
Frank J. A. van den Hoogen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Laryngeal Cancer ◽  
Neck Cancer ◽  
Functional Outcomes ◽  
Cochrane Library ◽  
Symptomatic Disease ◽  
Patient Reported ◽  
Time To Diagnosis

Objective An increased interval between symptomatic disease and treatment may negatively influence oncologic and/or functional outcomes in head and neck cancer (HNC). This systematic review aims to provide insight into the effects of time to treatment intervals on oncologic and functional outcomes in oral cavity, pharyngeal, and laryngeal cancer. Data Sources PubMed, EMBASE, and Cochrane library were searched. Review Methods All studies on delay or time to diagnosis or treatment in oral, pharyngeal, and laryngeal cancer were included. Quality assessment was performed with an adjusted version of the Newcastle-Ottawa scale. Outcomes of interest were tumor volume, stage, recurrence, survival, patient-reported outcome measures (PROMs), toxicity, and functionality after treatment. Results A total of 51 studies were included. Current literature on the influence of delay in HNC is inconsistent but indicates higher stage and worse survival with longer delay. The effects on PROMs, toxicity, and functional outcome after treatment have not been investigated. The inconsistencies in outcomes were most likely caused by factors such as heterogeneity in study design, differences in the definitions of delay, bias of results, and incomplete adjustment for confounding factors in the included studies. Conclusion Irrespective of the level of evidence, the unfavorable effects of delay on oncologic, functional, and psychosocial outcomes are undisputed. Timely treatment while maintaining high-quality diagnostic procedures and decision making reflects good clinical practice in our opinion. This review will pose practical and logistic challenges that will have to be overcome.

scholarly journals Durable Long-Term Remission With Chemotherapy Alone for Stage II to IV Laryngeal Cancer

2009 ◽  
Vol 27 (12) ◽  
pp. 1976-1982 ◽  
Author(s):  
F. Christopher Holsinger ◽  
Merrill S. Kies ◽  
Eduardo M. Diaz ◽  
Ann M. Gillenwater ◽  
Jan S. Lewin ◽  
...  
Keyword(s):  
Laryngeal Cancer ◽  
Pathologic Complete Response ◽  
Complete Response ◽  
Concurrent Chemotherapy ◽  
Stage Ii ◽  
High Rate ◽  
Disease Remission ◽  
Laryngeal Surgery ◽  
Platinum Based Chemotherapy

Purpose For patients with stage II to IV laryngeal cancer, radiation therapy (RT) either alone or with concurrent chemotherapy provides the highest rate of organ preservation but can be associated with functional impairment. Thus, we studied the use of induction chemotherapy with or without conservation laryngeal surgery (CLS). Our objectives were to study the sensitivity of laryngeal cancer to platinum-based chemotherapy alone and to highlight the efficacy of CLS in this setting. Patients and Methods Thirty-one previously untreated patients with laryngeal cancer (T2-4, N0-1, M0), who were resectable with CLS, were enrolled. Patients received three to four cycles of paclitaxel, ifosfamide, and cisplatin (TIP) chemotherapy, and response was assessed histologically. Patients with partial response (PR) proceeded to CLS. Patients achieving pathologic complete response (pCR) received an additional three cycles of TIP and no other treatment. Results Thirty patients were assessable for response. With TIP chemotherapy alone, 11 patients (37%) achieved pCR, 10 of whom (33%) remain alive with durable disease remission and no evidence of recurrence over a median follow-up time of 5 years. Nineteen patients (63%) treated with TIP alone achieved PR. The overall laryngeal preservation (LP) rate was 83%, and only five patients (16%) required postoperative RT. No patient required a gastrostomy tube or tracheotomy. Conclusion Chemotherapy alone in selected patients with T2-4, N0-1 laryngeal cancer can provide durable disease remission at 5 years. For patients with PR, CLS provides a high rate of LP. This prospective study suggests that chemotherapy alone may cure selected patients with laryngeal cancer, warranting further prospective investigation.

Neck Management in Patients Undergoing Postradiotherapy Salvage Laryngeal Surgery for Recurrent/Persistent Laryngeal Cancer

2006 ◽  
Vol 116 (10) ◽  
pp. 1864-1866 ◽  
Author(s):  
Tarik Y. Farrag ◽  
Frank R. Lin ◽  
Charles W. Cummings ◽  
Wayne M. Koch ◽  
Paul W. Flint ◽  
...  
Keyword(s):  
Laryngeal Cancer ◽  
Laryngeal Surgery

Salvage Conservation Laryngeal Surgery after Irradiation Failure for Early Laryngeal Cancer

2006 ◽  
Vol 116 (3) ◽  
pp. 451-455 ◽  
Author(s):  
Mehdi Motamed ◽  
Ollivier Laccourreye ◽  
Patrick J. Bradley
Keyword(s):  
Laryngeal Cancer ◽  
Laryngeal Surgery

scholarly journals ADVANCED LARYNGEAL CANCER (LITERATURE REVIEW)

2019 ◽  
Vol 18 (5) ◽  
pp. 97-107
Author(s):  
Z. A-G. Radzhabova ◽  
M. A. Kotov ◽  
M. A. Ebert ◽  
A. S. Mitrophanov ◽  
M. A. Radzhabova ◽  
...  
Keyword(s):  
Overall Survival ◽  
Laryngeal Cancer ◽  
Functional Outcomes ◽  
World Literature ◽  
Locally Advanced ◽  
Disease Free Survival ◽  
Chemoradiation Therapy ◽  
Cochrane Library ◽  
Tumor Control ◽  
The World

Background. Squamous carcinoma of the larynx is still the most common head and neck cancer in many Western countries. The larynx plays a key role for many essential functions, including breathing, voice production, airway protection, and swallowing. According to the world literature, 23,800 new cases of laryngeal cancer and 106,000 deaths from this disease are registered annually in the world. Laryngeal cancer treatment is aimed at achieving tumor control while optimizing functional outcomes.Objective: to review available data on surgical and non-surgical treatment options for locally advanced laryngeal cancer, as well as the evidence supporting each of these, including oncological outcomes (overall survival, disease-free survival, local control of the disease, functional outcomes and quality of life).Material and Methods. A systematic literature search was conducted in the electronic databases Medline, Cochrane Library, and Elibrary in the interval time between 1987 and 2016.Conclusions. In recent decades, the treatment paradigm for advanced laryngeal cancer has shifted from surgery (total laryngectomy) as the gold standard of treatment to nonsurgical organ-preserving treatment using radiation therapy or chemoradiation therapy. However, concerns have arisen regarding functional outcomes after chemoradiation therapy, as well as a possible reduction in overall survival in laryngeal cancer patients, risk factors, laryngectomy.

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