scholarly journals Influence of Cimetidine on Cardiovascular Parameters in Man

1979 ◽  
Vol 72 (12) ◽  
pp. 898-901 ◽  
Author(s):  
I O Samuel ◽  
J W Dundee
Keyword(s):  
Blood Pressure ◽  
Intensive Care Unit ◽  
Cardiac Output ◽  
Positive Pressure Ventilation ◽  
Intermittent Positive Pressure Ventilation ◽  
Positive Pressure ◽  
Dilution Method ◽  
Depressant Effect ◽  
Average Blood Pressure ◽  
Before And After

Cardiac output was measured in 10 patients using the dye dilution method, before and after the intravenous injection of 400 mg cimetidine. The subjects were in the intensive care unit and required intermittent positive pressure ventilation. There was no change in the average blood pressure, heart rate and cardiac output during the 60 minutes following the cimetidine, although one patient showed a marked fall in cardiac output. The results suggest that cimetidine is without a marked depressant effect on cardiovascular system.

Simple Device for Producing Continuous Negative Pressure in Infants With IRDS

PEDIATRICS ◽  
1973 ◽  
Vol 52 (1) ◽  
pp. 128-131
Author(s):  
Eduardo Bancalari ◽  
Tilo Gerhardt ◽  
Ellen Monkus
Keyword(s):  
Intensive Care Unit ◽  
Negative Pressure ◽  
Positive Pressure Ventilation ◽  
Newborn Infants ◽  
Transpulmonary Pressure ◽  
Intermittent Positive Pressure Ventilation ◽  
Positive Pressure ◽  
School Of Medicine ◽  
Newborn Intensive Care Unit ◽  
Newborn Intensive Care

Increasing experience with the use of continuous transpulmonary pressure, either positive or negative, during the last years has clearly demonstrated the success of this mode of therapy in IRDS.1-3 Forty newborn infants with this disease have been treated with continuous negative pressure (CNP) in the Newborn Intensive Care Unit, Department of Pediatrics, University of Miami School of Medicine, using a modified incubator-respirator.* Twenty-one required only CNP, three of whom died (14%). Among the 19 who needed CNP plus intermittent positive pressure ventilation, nine died (47%). All required more than 70% oxygen to maintain a Pao2 over 50 mm Hg before using CNP.

Effects of intermittent positive-pressure ventilation on cardiac output measurements by thermodilution

1986 ◽  
Vol 14 (11) ◽  
pp. 977-980 ◽  
Author(s):  
KAZUFUMI OKAMOTO ◽  
TORU KOMATSU ◽  
VIJAYA KUMAR ◽  
VAJUBHAI SANCHALA ◽  
KESHAV KUBAL ◽  
...  
Keyword(s):  
Cardiac Output ◽  
Positive Pressure Ventilation ◽  
Intermittent Positive Pressure Ventilation ◽  
Positive Pressure ◽  
Cardiac Output Measurements

scholarly journals Control of cross-infection in an intensive care unit

1969 ◽  
Vol 67 (3) ◽  
pp. 525-532 ◽  
Author(s):  
D. M. Harris ◽  
J. M. Orwin ◽  
J. Colquhoun ◽  
H. G. Schroeder
Keyword(s):  
Intensive Care Unit ◽  
Staphylococcus Aureus ◽  
Intensive Care ◽  
Positive Pressure Ventilation ◽  
Intensive Therapy ◽  
Intermittent Positive Pressure Ventilation ◽  
Cross Infection ◽  
Positive Pressure ◽  
Intensive Therapy Unit ◽  
And Staphylococcus Aureus

SUMMARYIn a survey undertaken in an intensive care unit, coliform bacilli were found to be responsible for most infections,Pseudomonas aeruginosaand Staphylococcus aureus being isolated much less frequently. Tracheostomy or endotracheal intubation predisposed to infection, but in our experience intermittent positive pressure ventilation did not significantly affect its incidence. Little cross-infection has occurred, and it has never been possible to incriminate the ventilators in its transmission.We gratefully acknowledge the assistance we have received from colleagues in the Intensive Therapy Unit and the Department of Bacteriology during the course of this investigation.

Effect of negative-pressure ventilation on lung water in permeability pulmonary edema

1989 ◽  
Vol 66 (5) ◽  
pp. 2223-2230 ◽  
Author(s):  
M. Skaburskis ◽  
R. P. Michel ◽  
A. Gatensby ◽  
A. Zidulka
Keyword(s):  
Cardiac Output ◽  
Pulmonary Edema ◽  
Positive Pressure Ventilation ◽  
Intermittent Positive Pressure Ventilation ◽  
Positive Pressure ◽  
Lung Water ◽  
Anesthetized Dogs ◽  
Water Accumulation ◽  
Permeability Pulmonary Edema ◽  
Continuous Positive Pressure

We have previously shown (Am. Rev. Respir. Dis. 136: 886–891, 1987) improved cardiac output in dogs with pulmonary edema ventilated with external continuous negative chest pressure ventilation (CNPV) using negative end-expiratory pressure (NEEP), compared with continuous positive-pressure ventilation (CPPV) using equivalent positive end-expiratory pressure (PEEP). The present study examined the effect on lung water of CNPV compared with CPPV to determine whether the increased venous return created by NEEP worsened pulmonary edema in dogs with acute lung injury. Oleic acid (0.06 ml/kg) was administered to 27 anesthetized dogs. Supine animals were then divided into three groups and ventilated for 6 h. The first group (n = 10) was treated with intermittent positive-pressure ventilation (IPPV) alone; the second (n = 9) received CNPV with 10 cmH2O NEEP; the third (n = 8) received CPPV with 10 cmH2O PEEP. CNPV and CPPV produced similar improvements in oxygenation over IPPV. However, cardiac output was significantly depressed by CPPV, but not by CNPV, when compared with IPPV. Although there were no differences in extravascular lung water (Qwl/dQl) between CNPV and CPPV, both significantly increased Qwl/dQl compared with IPPV (7.81 +/- 0.21 and 7.87 +/- 0.31 vs. 6.71 +/- 0.25, respectively, P less than 0.01 in both instances). CNPV and CPPV, but not IPPV, enhanced lung water accumulation in the perihilar areas where interstitial pressures may be most negative at higher lung volumes.

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