Normative Data of Hemoglobin Concentration and Free Erythrocyte Protoporphyrin in a Private Pediatric Practice

1986 ◽  
Vol 25 (4) ◽  
pp. 206-208 ◽  
Author(s):  
John T. Benjamin ◽  
Michael D. Dickens ◽  
Raymond F. Ford ◽  
Charles H. Gleason ◽  
Vito A. Perriello ◽  
...  
1991 ◽  
Vol 30 (2) ◽  
pp. 74-76 ◽  
Author(s):  
John T. Benjamin ◽  
Michael D. Dickens ◽  
Raymond F. Ford ◽  
David L. Hawkes ◽  
Charles W. Machen ◽  
...  

1989 ◽  
Vol 180 (1) ◽  
pp. 87-92 ◽  
Author(s):  
Koichi Harada ◽  
Shoko Omori ◽  
Tatsuro Ueno ◽  
Junichi Misumi ◽  
Hajime Miura

1981 ◽  
Vol 15 ◽  
pp. 590-590
Author(s):  
Eillott P Vichinsky ◽  
Klara M Kleman ◽  
Bertram H Lubin

Author(s):  
R.O. Morgan ◽  
G. Naglie ◽  
D.F. Horrobin ◽  
A. Barbeau

SummaryOf 13 patients with Fried-reich's ataxia (Type la) and 17 with type Ila recessive ataxias, all were found to have levels of “free erythrocyte protoporphyrin “ (FEP) above the normal range. The rise in FEP in Friedreich's ataxia correlated well with the age of the individual and thus appears to be related to the course of the disease. Subjects with olivo-ponto-cerebel-lar atrophy, Charlevoix syndrome, Duchenne muscular dystrophy, and Parkinson's disease were also found to have significantly elevated FEP, although the distribution overlapped with the normal range.The finding of elevated FEP may indicate a relative heme deficiency in ataxia due to inhibition offerrochelatase leading to a state of ineffective, persistent erythropoiesis. The possibility of a prosta-glandin abnormality being related to this defect and to the pathogenesis of ataxia is considered.


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