Human Acellular Dermal Matrix is a Viable Alternative to Autologous Skin Graft in Patients with Cutaneous Malignancy

2019 ◽  
Vol 85 (9) ◽  
pp. 1056-1060
Author(s):  
Rachel E. Lewis ◽  
Emily A. Towery ◽  
Sneha G. Bhat ◽  
Andrew J. Ward ◽  
Robert E. Heidel ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Cell Carcinoma ◽  
Donor Site ◽  
Acellular Dermal Matrix ◽  
Healing Time ◽  
Viable Alternative ◽  
Skin Substitutes ◽  
Dermal Matrix ◽  
Acellular Dermal ◽  
Human Acellular Dermal Matrix

Skin substitutes have shown success in complex wound reconstruction. We evaluate the use of a human acellular dermal matrix (ADM) as a viable alternative to autologous skin grafting for defects secondary to skin cancer excision. An institutional review board–approved, retrospective review of ADM-reconstructed defects secondary to skin cancer excision between 2012 and 2018 was conducted. ADM was indicated in patients with preclusive factors for general anesthesia, protracted procedure time, reluctance for additional donor site wound, and personal choice. We reviewed defect characteristics, healing time, postoperative outcomes, and patient demographics. The 228 participants (151 males, 77 females) had a median age of 72 years (range, 29–95 years), with melanoma diagnosed in 113 (49.6%), squamous cell carcinoma in 61 (26.8%), and basal cell carcinoma in 28 (12.2%) patients. The median interval to complete epidermal coverage was 42 days, with graft failure evident in six patients (2.6%). ADM is a viable, low-morbid alternative for reconstruction of defects secondary to skin cancer excision, with no donor site morbidity. With exception to complete healing time, outcomes are similar to those of autologous grafting.

scholarly journals Acellular dermal matrix as filler in breast-conserving surgery: warnings for a careful use

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Gianluca Franceschini ◽  
Riccardo Masetti
Keyword(s):  
Acellular Dermal Matrix ◽  
Breast Conserving Surgery ◽  
Human Origin ◽  
Dermal Matrix ◽  
Adequate Knowledge ◽  
Aesthetic Results ◽  
Dermal Matrices ◽  
Acellular Dermal ◽  
Human Acellular Dermal Matrix ◽  
Host Tissues

AbstractAcellular dermal matrices are biological materials of porcine, bovine, or human origin used as scaffold for reconstructive purpose in plastic surgery; these materials are well-tolerated and safely integrated in host tissues without causing resorption, contracture, and encapsulation thanks to their low antigenicity.Recently, human acellular dermal matrix has been used as a filler in breast-conserving surgery to improve aesthetic results. Adequate knowledge of biomaterials properties, appropriate skill, and careful compliance with some specific recommendations are mandatory in order to optimize outcomes and obtain a work of success.

Clinical Factors Influencing the Outcomes of an Acellular Dermal Matrix for Skin Cancer Treatment: A Retrospective Study

2020 ◽  
Vol 33 (7) ◽  
pp. 367-374
Author(s):  
Barbara Ferrari ◽  
Camilla Reggiani ◽  
Mariangela Francomano ◽  
Pierantonio Bellini ◽  
Federica Ferrari ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Skin Cancer ◽  
Cancer Treatment ◽  
Acellular Dermal Matrix ◽  
Clinical Factors ◽  
Dermal Matrix ◽  
Factors Influencing ◽  
Acellular Dermal

scholarly journals Reconstruction for Defects of Total Nail Bed and Germinal Matrix Loss with Acellular Dermal Matrix Coverage and Subsequently Skin Graft

Medicina ◽  
2020 ◽  
Vol 56 (1) ◽  
pp. 17
Author(s):  
Tsung-Hsien Liu ◽  
Meng-Chien Hsieh ◽  
Ping-Ruey Chou ◽  
Shu-Hung Huang
Keyword(s):  
Skin Graft ◽  
Donor Site ◽  
Acellular Dermal Matrix ◽  
Dermal Matrix ◽  
Germinal Matrix ◽  
Nail Bed ◽  
Staged Operation ◽  
Matrix Loss ◽  
Bone Exposure ◽  
Acellular Dermal

Background and Objectives: Nail bed and germinal matrix loss due to wide excision for fingertip tumors or malignancy are occasionally encountered complications. These defects also result from severely comminuted fingertip crush injuries. Large-area dorsal finger or toenail bed defects, which usually present with phalangeal bone exposure, remain challenging regardless of the usage of different reconstruction strategies. This study aimed to evaluate the clinical outcome of a staged operation with an acellular dermal matrix coverage and subsequent skin graft as reconstruction for defects of total nail bed, germinal matrix loss, and bone exposure. Materials and Methods: From April 2018 to October 2019, four patients with total nail bed, germinal matrix, and bone exposure loss after surgery were enrolled in our series. A staged operation of the acellular dermal matrix coverage with subsequent skin graft was performed on these patients. Skin graft take rate, oncological prognosis, and cosmetic outcome were evaluated. Patients were followed up for 5–13 months. An excellent skin graft take rate with a satisfying aesthetic result without local malignancy recurrence was noted. Minimal functional deficit and donor site morbidity were reported. Results: A staged operation with acellular dermal matrix coverage and subsequent skin graft proves to serve as a feasible strategy for patients who experience total nail bed, germinal matrix loss, and bone exposure after surgery. Conclusions: This reconstruction method provides a reliable repair result, satisfying aesthetic outcomes, as well as having minimal functional deficits and donor site morbidity.

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