Obsessive-compulsive disorder in patients with multiple sclerosis

1995 ◽  
Vol 7 (4) ◽  
pp. 507-510 ◽  
Keyword(s):  
Multiple Sclerosis ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

Obsessive compulsive disorder and multiple sclerosis: a case report implicating serotonergic dysfunction

1994 ◽  
Vol 11 (1) ◽  
pp. 26-27 ◽  
Author(s):  
Aideen Freyne ◽  
Rory K Shelley
Keyword(s):  
Multiple Sclerosis ◽  
Case Report ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Pharmacological Response ◽  
Serotonergic Pathway ◽  
Serotonergic Dysfunction

AbstractA patient who developed obsessive compulsive disorder within a year of developing multiple sclerosis is described. Possible reasons for an association between these two conditions are discussed. The role of serotonergic pathway dysfunction in obsessive compulsive disorder is also suggested by the pharmacological response in this case.

Obsessive Compulsive Disorder and Multiple Sclerosis: Three Cases

2010 ◽  
Vol 20 (2) ◽  
pp. 171-175
Author(s):  
Rabia Bilici ◽  
Nuray Türksoy Karalı ◽  
Nevin Sütlaş ◽  
Demet Kuşçu ◽  
Rıdvan Bilici
Keyword(s):  
Multiple Sclerosis ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals Neuroinflammation and Disrupted Synaptic Plasticity, the Main Pathological Processes in Multiple Sclerosis and Obsessive-Compulsive Disorder: An Enrichment Analysis

2020 ◽  
Author(s):  
Ali Sepehrinezhad ◽  
Ali Bozorgmehr ◽  
Sajad Sahab Negah ◽  
Minoo Karimi ◽  
Ali Shahbazi
Keyword(s):  
Multiple Sclerosis ◽  
Nervous System ◽  
Synaptic Plasticity ◽  
Obsessive Compulsive Disorder ◽  
Enrichment Analysis ◽  
Receptor Activity ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Functional Interactions ◽  
New Genes

Abstract Background: Multiple sclerosis (MS) is an autoimmune, inflammatory demyelinating, and disabling disorder of the central nervous system (CNS) with various clinical symptoms. Approximately 30% of the patients experience a variety of psychiatric problems during their disease course. Obsessive-compulsive disorder (OCD) is correlated with MS, but little is known about common molecular mechanisms of two diseases. Methods: In this study, after a comprehensive review of the existing literature, we collected almost all the genes involved in MS and OCD, and then analyzed the common genes between MS and OCD. Next, the connections and functional interactions between these three gene sets were investigated in the STRING database and analyzed in 3 separate networks by Cytoscape software. Eventually, after a multi-part enrichment analysis, we found the main molecular and cellular pathways, biological processes, brain areas, and, more importantly, cells/tissue related to the shared genes between MS and OCD. Results: Three genes of brain-derived neurotrophic factor (BDNF), tumor necrosis factor-alpha (TNFα), and neurexin-1 (NRXN1) are the major genes that were common between MS and OCD. Also, the deficit in synaptogenesis and neurotransmitter release in the nervous system are the most common complications of MS and OCD. Signaling receptor activity and estrogen receptor activity are the most important signaling pathways that are disturbed. Moreover, the presynaptic membrane, membrane raft, and growth cone are the main microenvironments that are affected in MS and OCD.Conclusions: In addition to an enrichment analysis that showed physical and functional interactions of genes related to MS and OCD, we demonstrated and predicted some new genes and microRNAs that can be promising biomarkers/targets for future experimental studies. Also, our finding indicated that neuroinflammation and synaptic plasticity are two significant pathological processes that are affected in MS and OCD.

Obsessive-compulsive disorder associated with parietal white matter multiple sclerosis plaques

2009 ◽  
Vol 10 (4-3) ◽  
pp. 956-960 ◽  
Author(s):  
Athanassios Douzenis ◽  
Panayiota G. Michalopoulou ◽  
Constantine Voumvourakis ◽  
Maria Typaldou ◽  
Ioannis Michopoulos ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals Structural Brain MR Imaging Changes Associated with Obsessive-Compulsive Disorder in Patients with Multiple Sclerosis

2012 ◽  
Vol 34 (2) ◽  
pp. 305-309 ◽  
Author(s):  
E. Tinelli ◽  
A. Francia ◽  
E.M. Quartuccio ◽  
M. Morreale ◽  
G.M. Contessa ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Mr Imaging ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Structural Brain

scholarly journals Clinical Significance of Immune Imbalance and Autoimmunity in Nervous System Disorders (NSDs)

2015 ◽  
Vol 16 (3-4) ◽  
Author(s):  
Vijendra K. Singh
Keyword(s):  
Multiple Sclerosis ◽  
Nervous System ◽  
Autoimmune Diseases ◽  
Obsessive Compulsive Disorder ◽  
Clinical Significance ◽  
Obsessive Compulsive ◽  
Global Database ◽  
Compulsive Disorder ◽  
Immune Imbalance

AbstractIn recent years, the role of immune imbalance and autoimmunity has been experimentally demonstrated in nervous system disorders (NSDs) that include Alzheimer’s disease, autism, obsessive-compulsive disorder (OCD), tics and Tourette’s syndrome, schizophrenia, and some other NSDs. And yet, these NSDs are never counted as autoimmune diseases. Deriving from the rapidly expanding knowledge of neuro-immunology and autoimmune diseases, for example multiple sclerosis (MS), the author of this mini-review strongly recommends that these NSDs should be included while tallying the number of autoimmune diseases. This effort will help create an updated global database of all autoimmune diseases as well as it should help treat millions of patients who are suffering from debilitating NSDs for which there is no known cure or treatment currently.

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