Positron-emission tomographic studies of the relationship of cerebral glucose metabolism and the magnitude of anxiety and hostility experienced during dreaming and waking

1991 ◽  
Vol 3 (2) ◽  
pp. 131-142 ◽  
Keyword(s):  
Glucose Metabolism ◽  
Cerebral Glucose Metabolism ◽  
Positron Emission Tomographic ◽  
Positron Emission ◽  
Relationship Of ◽  
The Relationship

scholarly journals Verbal Fluency and Positron Emission Tomographic Mapping of Regional Cerebral Glucose Metabolism

Cortex ◽  
1992 ◽  
Vol 28 (2) ◽  
pp. 231-239 ◽  
Author(s):  
Michael J. Boivin ◽  
Bruno Giordani ◽  
Stanley Berent ◽  
David A. Amato ◽  
Shirley Lehtinen ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Verbal Fluency ◽  
Cerebral Glucose Metabolism ◽  
Positron Emission Tomographic ◽  
Positron Emission ◽  
Tomographic Mapping ◽  
Regional Cerebral Glucose Metabolism

Relationship Between the Japanese Version of the Montreal Cognitive Assessment and PET Imaging in Subjects with Mild Cognitive Impairment

2019 ◽  
Vol 16 (9) ◽  
pp. 852-860 ◽  
Author(s):  
Atsuko Eguchi ◽  
Noriyuki Kimura ◽  
Yasuhiro Aso ◽  
Kenichi Yabuuchi ◽  
Masato Ishibashi ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Glucose Metabolism ◽  
Statistical Parametric Mapping ◽  
Japanese Version ◽  
Amyloid Deposition ◽  
Cerebral Glucose Metabolism ◽  
Positron Emission ◽  
The Relationship ◽  
Moca Score

Background: The Montreal Cognitive Assessment (MoCA) test has high sensitivity and specificity for detecting mild cognitive impairment or early dementia. How the MoCA score relates to findings of positron emission tomography imaging, however, remains unclear. <p></p> Objective: This prospective study examined the relationship between the Japanese version of the MoCA (MoCA-J) test and brain amyloid deposition or cerebral glucose metabolism among subjects with mild cognitive impairment. <p></p> Methods: A total of 125 subjects with mild cognitive impairment underwent the MoCA-J test, and amyloid- and 18F-fluorodeoxyglucose- positron emission tomography. Linear correlation analysis and multiple linear regression analysis were conducted to investigate the relationship between the MoCA-J score and demographic characteristics, amyloid deposition, and cerebral glucose metabolism. Moreover, Statistical Parametric Mapping 8 was used for a voxel-wise regression analysis of the MoCA-J score and cerebral glucose metabolism. <p></p> Results: The MoCA-J score significantly correlated with age, years of education, and the Mini-Mental State Examination score. After adjusting for age, sex, and education, the MoCA-J score significantly correlated negatively with amyloid retention (β= -0.174, p= 0.031) and positively with cerebral glucose metabolism (β= 0.183, p= 0.044). Statistical Parametric Mapping showed that Japanese version of MoCA score correlated with glucose metabolism in the bilateral frontal and parietal lobes, and the left precuneus. <p></p> Conclusion: The total MoCA-J score correlated with amyloid deposition and frontal and parietal glucose metabolism in subjects with mild cognitive impairment. Our findings support the usefulness of the MoCA-J test for screening subjects at high risk for Alzheimer’s disease.

scholarly journals Changes in cerebral glucose metabolism caused by morphologic features of prodromal idiopathic normal pressure hydrocephalus

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Koichi Miyazaki ◽  
Kohei Hanaoka ◽  
Hayato Kaida ◽  
Yasutaka Chiba ◽  
Kazunari Ishii
Keyword(s):  
Glucose Metabolism ◽  
Normal Pressure ◽  
Cerebral Glucose Metabolism ◽  
Emission Tomography ◽  
Fluorodeoxyglucose Positron Emission Tomography ◽  
Temporal Lobes ◽  
Parietal Lobes ◽  
Positron Emission ◽  
Asymptomatic Subjects ◽  
Fluorodeoxyglucose Positron Emission

Abstract Background Decreased cerebral glucose metabolism has been reported in idiopathic normal pressure hydrocephalus (iNPH). However, the timing of appearance in the preclinical stage of iNPH remains unknown. Herein, we evaluated the changes in regional cerebral glucose metabolism with respect to the characteristic morphologic features of iNPH. Methods We performed a cross-sectional study in > 2000 elderly patients who received a whole body 18F-fluorodeoxyglucose-positron emission tomography/computed tomography scanning and recruited subjects with clinical and preclinical iNPH. We included 12 subjects with iNPH, 32 subjects with asymptomatic ventriculomegaly with features of iNPH on magnetic resonance imaging (AVIM), and 33 subjects with preclinical morphologic features of DESH (PMD). We previously reported that iNPH develops in the order of PMD (asymptomatic subjects with incomplete DESH), AVIM (asymptomatic subjects with DESH), and iNPH (symptomatic subjects with DESH). We measured the median regional standardized uptake value ratio (SUVR) on 18F-fluorodeoxyglucose-positron emission tomography/computed tomography images between the three groups and compared them with background-matched normal controls in the frontal lobes, temporal lobes, medial parietal lobes, striata, and thalami. Results In the frontal and temporal lobes, the SUVR distributions of the PMD, AVIM, and PMD groups were significantly lower than for each NC (p < 0.05 for all). In the medial parietal lobes, the SUVR distributions were significantly higher in PMD and AVIM groups (p < 0.05 for all). In the thalami and striata, the SUVR distributions were significantly lower in the iNPH group (p < 0.05 for all). Conclusions Changes in brain glucose metabolism in the cortices are observed in preclinical iNPH, while metabolic decline in the basal ganglia is only detected in clinical iNPH.

scholarly journals Cerebral Glucose and Dopa Metabolism in Movement Disorders

1987 ◽  
Vol 14 (S3) ◽  
pp. 448-451 ◽  
Author(s):  
W.R. Wayne Martin ◽  
Michael R. Hayden
Keyword(s):  
At Risk ◽  
Glucose Metabolism ◽  
Normal Subjects ◽  
Cerebral Glucose Metabolism ◽  
Nigrostriatal Pathway ◽  
Age Related ◽  
Positron Emission ◽  
Asymptomatic Individuals ◽  
Regional Cerebral Glucose Metabolism

ABSTRACT:The development of positron emission tomography (PET) has enabled us to perform in vivo measurements of certain aspects of regional cerebral function. Regional cerebral glucose metabolism may be readily quantified with [18F] fluoro-2-deoxyglucose (FDG) and presynaptic dopaminergic function may be studied with the labelled dopa analog 6-[18F] fluoro-L-dopa. We have applied a model to the analysis of 6-FD/PET data with which in vivo age-related changes in dopaminergic function may be demonstrated in normal subjects. With this technique, we have studied a series of asymptomatic MPTP-exposed subjects and have shown evidence of subclinical nigrostriatal pathway damage. Studies of regional cerebral glucose metabolism with FDG in early Huntington's disease have shown a characteristic impairment in caudate function which precedes the development of caudate atrophy. In addition, some asymptomatic individuals who are at risk for HD have caudate hypometabolism. We feel that, at the present time, PET provides information which is complementary to the clinical examination in establishing a diagnosis of HD. In the future these studies may also help in the investigation of at risk individuals

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