Cognitive Performance in Relation to MRI Temporal Lobe Volume in Schizophrenic Patients and Healthy Control Subjects

2000 ◽  
Vol 12 (2) ◽  
pp. 251-256 ◽  
Author(s):  
Lydia Krabbendam ◽  
Mayke M. A. Derix ◽  
Adriaan Honig ◽  
Eric Vuurman ◽  
Rob Havermans ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Temporal Lobe ◽  
Control Subjects ◽  
Schizophrenic Patients ◽  
Healthy Control

Schizophrenic and Manic Brains in Nigerians Computerised Tomography Findings

1995 ◽  
Vol 166 (4) ◽  
pp. 496-500 ◽  
Author(s):  
Jude U. Ohaeri ◽  
Abiodun O. Adeyinka ◽  
Solomon N. Enyidah ◽  
Benjamin O. Osuntokun
Keyword(s):  
Psychiatric Patients ◽  
Third Ventricle ◽  
Developed Countries ◽  
Computerised Tomography ◽  
Brain Abnormality ◽  
Control Subjects ◽  
Duration Of Illness ◽  
Schizophrenic Patients ◽  
Healthy Control ◽  
Brain Ventricle

BackgroundWe highlight the profile of brain computerised tomography (CT) measures among Nigerian psychiatric patients for comparison with findings from developed countries, and study of the relationship between CT values and clinical variables.MethodSeven brain ventricle measures of 50 schizophrenic patients, 14 manic patients, and 41 healthy control subjects were compared.ResultsPatients had a significantly higher mean Sylvian fissure area. The third ventricle of schizophrenic patients was significantly larger than those of control subjects. CT measures were not significantly correlated with duration of illness.ConclusionThe so-called functional psychotic states are most probably associated with nonspecific brain abnormality.

Serum Copper in Schizophrenia in Nigerians

1975 ◽  
Vol 127 (2) ◽  
pp. 119-121 ◽  
Author(s):  
D. A. Olatunbosun ◽  
M. O. Akindele ◽  
B. K. Adadevoh ◽  
T. Asuni
Keyword(s):  
Atomic Absorption ◽  
Normal Control ◽  
Atomic Absorption Spectrophotometry ◽  
Serum Copper ◽  
Absorption Spectrophotometry ◽  
Control Subjects ◽  
Schizophrenic Patients ◽  
Healthy Control ◽  
The Difference ◽  
Average Serum

SummarySerum copper concentrations were determined by atomic absorption spectrophotometry in 102 schizophrenic patients and 95 healthy control subjects. The serum copper concentrations were significantly higher in the schizophrenic patients than in the normal control subjects. The average serum copper in schizophrenic females was higher than in schizophrenic males, but the difference was not statistically significant

scholarly journals Dissimilarity in Sulcal Width Patterns in the Cortex can be Used to Identify Patients With Schizophrenia With Extreme Deficits in Cognitive Performance

2020 ◽  
Author(s):  
Joost Janssen ◽  
Covadonga M Díaz-Caneja ◽  
Clara Alloza ◽  
Anouck Schippers ◽  
Lucía de Hoyos ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Similarity Index ◽  
Brain Morphology ◽  
Healthy Controls ◽  
Interindividual Differences ◽  
Complex Disorder ◽  
Control Subjects ◽  
Healthy Control ◽  
Regional Deficits ◽  
Cortical Regions

Abstract Schizophrenia is a biologically complex disorder with multiple regional deficits in cortical brain morphology. In addition, interindividual heterogeneity of cortical morphological metrics is larger in patients with schizophrenia when compared to healthy controls. Exploiting interindividual differences in the severity of cortical morphological deficits in patients instead of focusing on group averages may aid in detecting biologically informed homogeneous subgroups. The person-based similarity index (PBSI) of brain morphology indexes an individual’s morphometric similarity across numerous cortical regions amongst a sample of healthy subjects. We extended the PBSI such that it indexes the morphometric similarity of an independent individual (eg, a patient) with respect to healthy control subjects. By employing a normative modeling approach on longitudinal data, we determined an individual’s degree of morphometric dissimilarity to the norm. We calculated the PBSI for sulcal width (PBSI-SW) in patients with schizophrenia and healthy control subjects (164 patients and 164 healthy controls; 656 magnetic resonance imaging scans) and associated it with cognitive performance and cortical sulcation index. A subgroup of patients with markedly deviant PBSI-SW showed extreme deficits in cognitive performance and cortical sulcation. Progressive reduction of PBSI-SW in the schizophrenia group relative to healthy controls was driven by these deviating individuals. By explicitly leveraging interindividual differences in the severity of PBSI-SW deficits, neuroimaging-driven subgrouping of patients is feasible. As such, our results pave the way for future applications of morphometric similarity indices for subtyping of clinical populations.

scholarly journals Dissimilarity in sulcal width patterns in the cortex can be used to identify patients with schizophrenia with extreme deficits in cognitive performance

2020 ◽  
Author(s):  
Joost Janssen ◽  
Covadonga M. Díaz-Caneja ◽  
Clara Alloza ◽  
Anouck Schippers ◽  
Lucía de Hoyos ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Similarity Index ◽  
Brain Morphology ◽  
Healthy Controls ◽  
Interindividual Differences ◽  
Control Subjects ◽  
Mri Scans ◽  
Healthy Control ◽  
Regional Deficits ◽  
Cortical Regions

AbstractSchizophrenia is a biologically complex disorder with multiple regional deficits in cortical brain morphology. In addition, interindividual heterogeneity of cortical morphological metrics is larger in patients with schizophrenia when compared to healthy controls. Exploiting interindividual differences in severity of cortical morphological deficits in patients instead of focusing on group averages may aid in detecting biologically informed homogeneous subgroups. The Person-Based Similarity Index (PBSI) of brain morphology indexes an individual’s morphometric similarity across numerous cortical regions amongst a sample of healthy subjects. We extended the PBSI such that it indexes morphometric similarity of an independent individual (e.g., a patient) with respect to healthy control subjects. By employing a normative modeling approach on longitudinal data, we determined an individual’s degree of morphometric dissimilarity to the norm. We calculated the PBSI for sulcal width (PBSI-SW) in patients with schizophrenia and healthy control subjects (164 patients, 164 healthy controls; 656 MRI scans) and associated it with cognitive performance and cortical sulcation index. A subgroup of patients with markedly deviant PBSI-SW showed extreme deficits in cognitive performance and cortical sulcation. Progressive reduction of PBSI-SW in the schizophrenia group relative to healthy controls was driven by these deviating individuals. By explicitly leveraging interindividual differences in severity of PBSI-SW deficits, neuroimaging-driven subgrouping of patients is feasible. As such, our results pave the way for future applications of morphometric similarity indices for subtyping of clinical populations.

Enhancement of Platelet Sensitivity to ADP-Aggregation by Isometric Exercise in Arteriosclerotic Patients and its Prevention

1977 ◽  
Vol 37 (02) ◽  
pp. 329-338 ◽  
Author(s):  
Tadahiro Sano ◽  
Takeshi Motomiya ◽  
Hiroh Yamazaki ◽  
Takio Shimamoto
Keyword(s):  
Cyclic Amp ◽  
Mechanical Stress ◽  
Optical Density ◽  
Platelet Function ◽  
Isometric Exercise ◽  
Phosphodiesterase Inhibitor ◽  
New Method ◽  
Platelet Aggregability ◽  
Control Subjects ◽  
Healthy Control

SummaryA new method for assessment of platelet sensitivity to ADP-aggregation was devised. Its reproducibility and the correlations between the values obtained by this method, the optical density (O. D.) method, and the screen filtration pressure (SFP) method were assessed. In summary, this method may be said to have three main points:1. It can be performed without centrifugation, avoiding mechanical stress to platelets, using only 0.8 ml. of blood and inexpensive equipment.2. It may reflect different aspects of platelet function from the O. D. method and the SFP method, despite the positive significant correlations between the values obtained by these three methods.3. It was proved to be highly reproducible and is thought to be useful clinically.By using this method, the effect of sustained isometric exercise by handgripping on platelet aggregability was assessed in coronary sclerotic and cerebral arteriosclerotic patients on placebo and EG-626, a newly synthesized cyclic AMP phosphodiesterase inhibitor. On placebo, an enhancement of platelet sensitivity was observed after isometric exercise in coronary and cerebral arteriosclerotic patients but not in healthy control subjects. The enhancement was prevented by pretreatment of EG-626, administered orally 1.5 hours prior to exercise.

Some Cytokines Levels (IL-6 and IL-10) in Sera Patients with Cutaneous Leismanasis in Nassiriya Province

2020 ◽  
pp. 4-6
Keyword(s):  
Serum Level ◽  
Immune Status ◽  
Pure Science ◽  
Control Subjects ◽  
Significant Difference ◽  
Healthy Control

The present study was carried out in the Labs of collage of education for pure science, during period from January 2017 to endDecember of the same year. The immune status investigates for CLpatients by measuring the levels of cytokines (IL6and IL10) in sera using a technique enzyme-linked immune Sorbent adsorptive (ELISA). The study included 120 subjects with (60 CLpatientsL.majar and 60 CLpatients L. tropica with and (30) were healthy control. Increased mean Serum level of IL6 was in the observed in the total patients as compared to control Subjects (224.53pg/ml,70.70pg/ml), the result indicate there was significant difference at (p<0.05) ,such observation was consistent in the patient infected with L.majar and L. tropica (104 .90 pg/ml and 112.78 pg/ml) respectively. The results of the IL10 showed significant difference at (p<0.05)increased of mean Serum level in the total CL patients as compared to control Subjects(226.90 pg/ml 46.77pg/ml,).Ahighly significant difference at (p<0.05) increased observed in patients group infected with L.majar and followed by patients group infected L. tropica (112.78pg/ml and 114.12pg/ml) respectively.These results revealed that the excessive presence of cytokines might play a role in CL patients.

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