Depression and IL-6 Blood Plasma Concentrations in Advanced Cancer Patients

2008 ◽  
Vol 49 (1) ◽  
pp. 64-66 ◽  
Author(s):  
Colleen M. Jacobson ◽  
Barry Rosenfeld ◽  
Hayley Pessin ◽  
William Breitbart
Keyword(s):  
Blood Plasma ◽  
Cancer Patients ◽  
Advanced Cancer ◽  
Plasma Concentrations ◽  
Advanced Cancer Patients

The oral-to-intravenous equianalgesic ratio of morphine based on plasma concentrations of morphine and metabolites in advanced cancer patients receiving chronic morphine treatment

2003 ◽  
Vol 17 (8) ◽  
pp. 673-678
Author(s):  
Masahiko Takahashi ◽  
Takeshi Ohara ◽  
Hiroyuki Yamanaka ◽  
Akira Shimada ◽  
Toshimichi Nakaho ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Advanced Cancer ◽  
Plasma Concentrations ◽  
Relative Potency ◽  
Morphine Treatment ◽  
Advanced Cancer Patients ◽  
Chronic Morphine ◽  
Potency Ratio ◽  
Palliative Care Setting ◽  
Chronic Morphine Treatment

To provide additional pharmacokinetic evidence for the oral-to-parenteral relative potency ratio of 1:2 to 1:3 for chronic morphine use in a palliative care setting, we determined the plasma concentrations of morphine and its major metabolites, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G), in hospitalized advanced cancer patients maintained on long-term oral or intravenous morphine. There were significant linear correlations between daily doses of morphine and plasma concentrations (molar base) of morphine, M3G and M6G for both routes of administration. The oral-to-intravenous relative ratios of the regression coefficients were 2.9 for morphine and 1.8 for morphine» / M6G. The morphine kinetic variables were not significantly influenced by any hepato-renal biochemical markers. These results support the commonly used oral-to-intravenous relative potency ratio of 1:2 to 1:3 in patients with cancer pain receiving chronic morphine treatment.

scholarly journals Higher oxidation and lower antioxidant levels in peripheral blood plasma and bone marrow plasma from advanced cancer patients

Cancer ◽  
2002 ◽  
Vol 94 (12) ◽  
pp. 3247-3251 ◽  
Author(s):  
Elena M. V. de Cavanagh ◽  
Alba E. Honegger ◽  
Erica Hofer ◽  
Raul H. Bordenave ◽  
Eduardo O. Bullorsky ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Blood Plasma ◽  
Cancer Patients ◽  
Advanced Cancer ◽  
Peripheral Blood ◽  
Advanced Cancer Patients ◽  
Bone Marrow Plasma ◽  
Peripheral Blood Plasma
Sign in / Sign up

Export Citation Format

Share Document