scholarly journals Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder

2015 ◽  
Vol 13 (2) ◽  
pp. 204-212
Author(s):  
Stella J. de Wit ◽  
Pino Alonso ◽  
Lizanne Schweren ◽  
David Mataix-Cols ◽  
Christine Lochner ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Voxel Based Morphometry ◽  
Obsessive Compulsive ◽  
Brain Scans ◽  
Compulsive Disorder ◽  
Structural Brain

scholarly journals Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder

2014 ◽  
Vol 171 (3) ◽  
pp. 340-349 ◽  
Author(s):  
Stella J. de Wit ◽  
Pino Alonso ◽  
Lizanne Schweren ◽  
David Mataix-Cols ◽  
Christine Lochner ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Voxel Based Morphometry ◽  
Obsessive Compulsive ◽  
Brain Scans ◽  
Compulsive Disorder ◽  
Structural Brain

scholarly journals Cortical thickness in obsessive–compulsive disorder: Multisite mega-analysis of 780 brain scans from six centres

2017 ◽  
Vol 210 (1) ◽  
pp. 67-74 ◽  
Author(s):  
Jean-Paul Fouche ◽  
Stefan du Plessis ◽  
Coenie Hattingh ◽  
Annerine Roos ◽  
Christine Lochner ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Cortical Thickness ◽  
Group Analysis ◽  
Analysis Of Covariance ◽  
Group Differences ◽  
Grey Matter Volume ◽  
Obsessive Compulsive ◽  
Brain Scans ◽  
Compulsive Disorder

BackgroundThere is accumulating evidence for the role of fronto-striatal and associated circuits in obsessive–compulsive disorder (OCD) but limited and conflicting data on alterations in cortical thickness.AimsTo investigate alterations in cortical thickness and subcortical volume in OCD.MethodIn total, 412 patients with OCD and 368 healthy adults underwent magnetic resonance imaging scans. Between-group analysis of covariance of cortical thickness and subcortical volumes was performed and regression analyses undertaken.ResultsSignificantly decreased cortical thickness was found in the OCD group compared with controls in the superior and inferior frontal, precentral, posterior cingulate, middle temporal, inferior parietal and precuneus gyri. There was also a group x age interaction in the parietal cortex, with increased thinning with age in the OCD group relative to controls.ConclusionsOur findings are partially consistent with earlier work, suggesting that group differences in grey matter volume and cortical thickness could relate to the same underlying pathology of OCD. They partially support a frontostriatal model of OCD, but also suggest that limbic, temporal and parietal regions play a role in the pathophysiology of the disorder. The group x age interaction effects may be the result of altered neuroplasticity.

scholarly journals Structural Brain MR Imaging Changes Associated with Obsessive-Compulsive Disorder in Patients with Multiple Sclerosis

2012 ◽  
Vol 34 (2) ◽  
pp. 305-309 ◽  
Author(s):  
E. Tinelli ◽  
A. Francia ◽  
E.M. Quartuccio ◽  
M. Morreale ◽  
G.M. Contessa ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Mr Imaging ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Structural Brain

scholarly journals Mapping Structural Brain Alterations in Obsessive-Compulsive Disorder

2004 ◽  
Vol 61 (7) ◽  
pp. 720 ◽  
Author(s):  
Jesús Pujol ◽  
Carles Soriano-Mas ◽  
Pino Alonso ◽  
Narcís Cardoner ◽  
José M. Menchón ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Structural Brain ◽  
Structural Brain Alterations
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