Triggering the false suffocation alarm in panic disorder patients by using a voluntary breath-holding procedure

1994 ◽  
Vol 151 (2) ◽  
pp. 264-266 ◽  
2009 ◽  
pp. 383-392 ◽  
Author(s):  
P Kolář ◽  
J Neuwirth ◽  
J Šanda ◽  
V Suchánek ◽  
Z Svatá ◽  
...  

Using magnetic resonance imaging (MRI) in conjunction with synchronized spirometry we analyzed and compared diaphragm movement during tidal breathing and voluntary movement of the diaphragm while breath holding. Breathing cycles of 16 healthy subjects were examined using a dynamic sequence (77 slices in sagittal plane during 20 s, 1NSA, 240x256, TR4.48, TE2.24, FA90, TSE1, FOV 328). The amplitude of movement of the apex and dorsal costophrenic angle of the diaphragm were measured for two test conditions: tidal breathing and voluntary breath holding. The maximal inferior and superior positions of the diaphragm were subtracted from the corresponding positions during voluntary movements while breath holding. The average amplitude of inferio-superior movement of the diaphragm apex during tidal breathing was 27.3±10.2 mm (mean ± SD), and during voluntary movement while breath holding was 32.5±16.2 mm. Movement of the costophrenic angle was 39±17.6 mm during tidal breathing and 45.5±21.2 mm during voluntary movement while breath holding. The inferior position of the diaphragm was lower in 11 of 16 subjects (68.75 %) and identical in 2 of 16 (12.5 %) subjects during voluntary movement compared to the breath holding. Pearson’s correlation coefficient was used to demonstrate that movement of the costophrenic angle and apex of the diaphragm had a linear relationship in both examined situations (r=0.876). A correlation was found between the amplitude of diaphragm movement during tidal breathing and lung volume (r=0.876). The amplitude of movement of the diaphragm with or without breathing showed no correlation to each other (r=0.074). The movement during tidal breathing shows a correlation with the changes in lung volumes. Dynamic MRI demonstrated that individuals are capable of moving their diaphragm voluntarily, but the amplitude of movement differs from person to person. In this study, the movements of the diaphragm apex and the costophrenic angle were synchronous during voluntary movement of the diaphragm while breath holding. Although the sample is small, this study confirms that the function of the diaphragm is not only respiratory but also postural and can be voluntarily controlled.


2006 ◽  
Vol 142 (2-3) ◽  
pp. 201-208 ◽  
Author(s):  
Antonio E. Nardi ◽  
Alexandre M. Valença ◽  
Marco A. Mezzasalma ◽  
Sandra P. Levy ◽  
Fabiana L. Lopes ◽  
...  

2015 ◽  
Vol 88 (1054) ◽  
pp. 20150309 ◽  
Author(s):  
Ruth Colgan ◽  
Matthew James ◽  
Frederick R Bartlett ◽  
Anna M Kirby ◽  
Ellen M Donovan

PEDIATRICS ◽  
1985 ◽  
Vol 75 (1) ◽  
pp. 76-79
Author(s):  
Nick G. Anas ◽  
John T. McBride ◽  
Christian Boettrich ◽  
Kenneth McConnochie ◽  
John G. Brooks

The ability of children with cyanotic breath-holding spells to respond to anger or frustration by voluntary breath-holding for prolonged periods (often to the point of precipitating hypoxic seizure activity) suggested the hypothesis that such children may have a less powerful urge to breathe in the presence of hypoxia and/or hypercapnia than children who do not have breath-holding spells. Because ventilatory chemosensitivity is difficult to measure in infants and young children, this hypothesis was tested indirectly by measuring the ventilatory responses to hyperoxic progressive hypercapnia and to isocapnic progressive hypoxia of seven individuals who had a history of cyanotic breath-holding spells in infancy and 17 control subjects. The mean values for sensitivity to hypoxia and to hypercapnia were not significantly different between the two groups, and the responses of the majority of the subjects with cyanotic breath-holding spells were clearly within the normal range. There were fewer individuals with high-normal ventilatory responses among the subjects with cyanotic breath-holding spells. Although children with cyanotic breath-holding spells may have decreased ventilatory chemosensitivity transiently during infancy or may differ from other children in some other aspect of the control of breathing, the pathogenesis of infantile cyanotic breath-holding spells does not involve a permanently blunted sensitivity to hypercapnia or hypoxia.


1983 ◽  
Vol 55 (6) ◽  
pp. 1777-1783 ◽  
Author(s):  
L. J. Findley ◽  
A. L. Ries ◽  
G. M. Tisi ◽  
P. D. Wagner

Seven normal awake males were studied to define the mechanisms and impact of lung volume on the hypoxemia occurring during apnea. During repeated 30-s voluntary breath holding, these subjects were studied at different lung volumes, during various respiratory maneuvers, and in the sitting and supine body positions. Analysis of expired gases and arterial O2 saturation during these repeated breath holdings yielded the following conclusions. Apnea of 30-s duration at low lung volumes is accompanied by severe arterial O2 desaturation in normal awake subjects. Initial lung volume is the most important determinant of hypoxemia during apnea. The hypoxemia of apnea at most lung volumes can be explained by simple alveolar hypoventilation in a uniform lung. The lung does not behave as a single-compartment model at lung volumes at which dependent airways are susceptible to closure.


1992 ◽  
Vol 33 (1) ◽  
pp. 47-51 ◽  
Author(s):  
Jan Zandbergen ◽  
Maja Strahm ◽  
Henk Pols ◽  
Eric J.L. Griez

2021 ◽  
pp. 108196
Author(s):  
Elischa Krause ◽  
Christoph Benke ◽  
Alfons O. Hamm ◽  
Christiane A. Pané-Farré

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