Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression

1993 ◽  
Vol 150 (4) ◽  
pp. 656-657 ◽  
Keyword(s):  
Major Depression ◽  
Arginine Vasopressin ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Fluoxetine Treatment

Consistent Reduction of ACTH responses to stimulation with CRH, Vasopressin and Hypoglycaemia in Patients with Major Depression

1989 ◽  
Vol 155 (4) ◽  
pp. 468-478 ◽  
Author(s):  
Roger G. Kathol ◽  
Richard S. Jaeckle ◽  
Juan F. Lopez ◽  
William H. Meller
Keyword(s):  
Major Depression ◽  
Hpa Axis ◽  
Negative Correlation ◽  
Arginine Vasopressin ◽  
Corticotropin Releasing Hormone ◽  
Hypothalamic Pituitary Adrenal ◽  
Releasing Hormone ◽  
Control Subjects ◽  
Basal Cortisol ◽  
Cortisol Responses

Eleven patients with major depression and 12 control subjects were administered corticotropin-releasing hormone (CRH), aqueous arginine vasopressin (AVP), and insulin hypoglycaemia (IH) to test for differences in hypothalamic–pituitary–adrenal (HPA) axis function. Patients with major depression demonstrated lower ACTH responses to CRH when compared with controls, and a trend toward such after administration of AVP. Despite lower ACTH responses in patients with depression, there were no differences in Cortisol responses to these stimuli. In the CRH and AVP tests, there was no correlation between the basal Cortisol and ACTH responses in either controls or patients, but in the IH test there was a negative correlation between these responses for both groups. The ACTH responses to CRH and AVP were positively correlated in controls and patients. Cortisol responses to all three provocative stimuli were positively correlated in both subject groups. These findings are consistent with the hypothesis that hypothalamic or supra-hypothalamic overactivity may be involved in the development of HPA-axis abnormalities in patients with depression.

Release of hypothalamic corticotropin-releasing hormone and arginine-vasopressin by interleukin 1β and αMSH: studies in rats with different susceptibility to inflammatory disease

1993 ◽  
Vol 631 (1) ◽  
pp. 22-26 ◽  
Author(s):  
Piotr Zelazowski ◽  
Vladimir K. Patchev ◽  
Elzbieta B. Zelazowska ◽  
George P. Chrousos ◽  
Philip W. Gold ◽  
...  
Keyword(s):  
Arginine Vasopressin ◽  
Inflammatory Disease ◽  
Interleukin 1Β ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone

Glucocorticoids and Relapse of Major Depression (Dexamethasone/Corticotropin-Releasing Hormone Test in Relation to Relapse of Major Depression)

2006 ◽  
Vol 59 (8) ◽  
pp. 696-701 ◽  
Author(s):  
Bente C. Appelhof ◽  
Jochanan Huyser ◽  
Mijke Verweij ◽  
Jantien P. Brouwer ◽  
Richard van Dyck ◽  
...  
Keyword(s):  
Major Depression ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone
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