Family history and CSF homovanillic acid pattern during neuroleptic treatment

1984 ◽  
Vol 141 (2) ◽  
pp. 296-298 ◽  
Keyword(s):  
Family History ◽  
Homovanillic Acid ◽  
Neuroleptic Treatment ◽  
Csf Homovanillic Acid

Low CSF Concentrations of Cyclic GMP in Schizophrenia

1983 ◽  
Vol 142 (3) ◽  
pp. 288-291 ◽  
Author(s):  
W. F. Gattaz ◽  
H. Cramer ◽  
H. Beckmann
Keyword(s):  
Cerebrospinal Fluid ◽  
Cyclic Gmp ◽  
Homovanillic Acid ◽  
Healthy Controls ◽  
Neuroleptic Treatment ◽  
Cholinergic Activity ◽  
Schizophrenic Patients ◽  
Csf Levels

SummaryIncreasing evidence suggests that the concentrations of cyclic guanosine 3′5′-monophosphate (cGMP) in the cerebrospinal fluid (CSF) may reflect central cholinergic activity. When the concentrations of this nucleotide in the CSF from 28 schizophrenic patients (13 without and 15 with neuroleptic treatment) and 16 psychiatrically healthy controls was determined the schizophrenics showed significantly lower CSF levels of cGMP as compared to controls.As dopamine and homovanillic acid concentrations were not altered in these CSF samples, this finding of reduced cGMP suggests a cholinergic-dopaminergic imbalance in schizophrenia, with a reduction of the former and consequently a relative dominance of the latter.

Effects of clozapine on CSF homovanillic acid in spasmodic torticollis

1994 ◽  
Vol 97 (3) ◽  
pp. 245-251
Author(s):  
A. Thiel ◽  
D. Dressler ◽  
A. Reimer ◽  
E. Rüther
Keyword(s):  
Homovanillic Acid ◽  
Spasmodic Torticollis ◽  
Csf Homovanillic Acid

The Expression of Schizophrenia, Affective Disorder and Vulnerability to Tardive Dyskinesia in an Extensive Pedigree

1988 ◽  
Vol 153 (3) ◽  
pp. 376-381 ◽  
Author(s):  
John L. Waddington ◽  
Hanafy A. Youssef
Keyword(s):  
Family History ◽  
Tardive Dyskinesia ◽  
Movement Disorder ◽  
Affective Disorder ◽  
Psychiatric Illness ◽  
Late Onset ◽  
Psychiatric Morbidity ◽  
Neuroleptic Treatment ◽  
History Of

The demography, psychiatric morbidity, and motor consequences of long-term neuroleptic treatment in the 14 children born to a father with a family history of chronic psychiatric illness and a mother with a late-onset affective disorder resulting in suicide are documented. Twelve siblings lived to adulthood, nine of whom were admitted to a psychiatric hospital in their second or third decade, and required continuous in-patient care; five remaining in hospital, with long-term exposure to neuroleptics, had chroniC., deteriorating, schizophrenic illness and emergence of movement disorder. Two siblings showed no evidence of psychosis but developed a late-onset affective disorder. The implications for the issues of homotypia, vulnerability to involuntary movements, and interaction with affective disorder are discussed.

Evidence of Disturbed CSF Circulation and Brain Atrophy in Cases of Schizophrenic Psychosis

1984 ◽  
Vol 144 (6) ◽  
pp. 654-661 ◽  
Author(s):  
G. Bergstrand ◽  
L. Bjerkenstedt ◽  
G. Oxenstierna ◽  
G. Sedvall ◽  
G. Wik
Keyword(s):  
Cerebrospinal Fluid ◽  
Family History ◽  
Brain Atrophy ◽  
The Other ◽  
Pathological Findings ◽  
Neuroleptic Treatment ◽  
Csf Circulation ◽  
Frontal Part ◽  
Interhemispheric Fissure ◽  
Isotope Cisternography

SummaryThe cerebrospinal fluid (CSF) circulation was studied with isotope cisternography in 30 patients with a schizophrenic type of psychosis. All had previously received neuroleptic treatment. Disturbed CSF circulation was found in 10 cases. In four of these, persistent intraventricular radioactivity was observed as well as partly obstructed CSF spaces. In the other six cases a slow CSF circulation was noted as well as evidence of partly obstructed CSF spaces especially of the upper posterior frontal region. Signs of atrophy of the cortex and vermis were found on CT scan in 10 cases. In four of these subjects a local atrophy was noticed in the upper posterior frontal cortex and around the frontal part of the interhemispheric fissure. Seventeen of the patients (57 per cent) had pathological findings at isotope cisternography and/or at CT. Disturbed circulation did not correlate with CT-findings, age, duration of psychosis, alcohol abuse, drug consumption or family history for psychosis. CT evidence of brain atrophy was significantly related to nonfamilial type of psychosis.

Brain monoamine metabolites and tryptophan in ventricular CSF of patients with spasm after aneurysm surgery

1978 ◽  
Vol 48 (1) ◽  
pp. 58-63 ◽  
Author(s):  
Matti Vapalahti ◽  
Markku T. Hyyppä ◽  
Vappu Nieminen ◽  
Urpo K. Rinne
Keyword(s):  
Homovanillic Acid ◽  
Arterial Aneurysm ◽  
Monoamine Metabolites ◽  
Aneurysm Surgery ◽  
Increased Intracranial Pressure ◽  
Content Type ◽  
Direct Support ◽  
The Mean ◽  
Csf Homovanillic Acid ◽  
Fine Print

✓ Intraventricular pressure was followed continuously after operation for intracranial arterial aneurysm in 20 patients. Ventricular cerebrospinal fluid (CSF), homovanillic acid (HVA), tryptophan, and 5-hydroxyindole acetic acid (5-HIAA) were analyzed daily for 5 days, beginning before the clipping of the aneurysm. Postoperatively, seven patients had spasm, verified clinically and angiographically. Seven other patients with no clinical or angiographic signs of spasm, hydrocephalus, or increased intracranial pressure (ICP) served as controls. Nine of the 20 patients were hydrocephalic. The mean ± SE values of HVA, tryptophan, and 5-HIAA in the controls were 264 ± 40, 1116 ± 85, and 88 ± 8 ng/ml, respectively, in the controls, and 182 ± 20, 982 ± 89, and 78 ± 3 ng/ml, respectively, in the patients with spasm. The differences are not statistically significant. However, the low values of HVA may have been produced by ischemic changes caused by the spasm. In hydrocephalic patients ventricular CSF tryptophan levels were statistically significantly higher, and 5-HIAA levels lower than in controls. In patients with increased ICP, neither alterations nor intercorrelations of monoamine metabolites and tryptophan were found. The results do not give direct support to prophylactic neuropharmacological treatment of postoperative arterial cerebral spasm. However, ventricular HVA, tryptophan, and 5-HIAA measurements can be used for prognostic purposes during the first few days after the operation.

CSF homovanillic acid predicts behavioral response to stimulants in 47 ADHD boys

1995 ◽  
Vol 37 (9) ◽  
pp. 644
Author(s):  
F.X. Castellanos ◽  
J. Elia ◽  
M.J.P. Kruesi ◽  
W.L. Marsh ◽  
W.Z. Potter ◽  
...  
Keyword(s):  
Behavioral Response ◽  
Homovanillic Acid ◽  
Csf Homovanillic Acid
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