scholarly journals Evolutionary history of metastatic breast cancer reveals minimal seeding from axillary lymph nodes

2018 ◽  
Vol 128 (4) ◽  
pp. 1355-1370 ◽  
Author(s):  
Ikram Ullah ◽  
Govindasamy-Muralidharan Karthik ◽  
Amjad Alkodsi ◽  
Una Kjällquist ◽  
Gustav Stålhammar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Nodes ◽  
Evolutionary History ◽  
Metastatic Breast ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
History Of

scholarly journals Prostate-Specific Ets (PSE) factor: a novel marker for detection of metastatic breast cancer in axillary lymph nodes

2002 ◽  
Vol 86 (6) ◽  
pp. 899-904 ◽  
Author(s):  
M Mitas ◽  
K Mikhitarian ◽  
L Hoover ◽  
M A Lockett ◽  
L Kelley ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Nodes ◽  
Metastatic Breast ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph

scholarly journals Breast Cancer with Internal Mammary Node Metastases: A Case Presented in a Tumor Board Session and Decision Making

2019 ◽  
pp. 156-160
Author(s):  
Léamarie Meloche-Dumas ◽  
Erica Patocskai ◽  
Kerianne Boulva ◽  
Moishe Liberman ◽  
Younan Rami
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Metastatic Breast ◽  
Tumor Board ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Internal Mammary Chain ◽  
Internal Mammary

Background: There are several therapeutic options available for breast cancer treatment, now incorporating innovative targeted molecular therapies. Metastatic breast cancer is usually treated with chemotherapy and/or hormonotherapy. Surgery has not been shown to improve survival. Adjuvant radiotherapy (RT) has been proven to be effective in the treatment of locally advanced breast cancer, reducing locoregional recurrence. The optimal treatment of internal mammary lymph nodes (IMN) metastases remains controversial. Case presentation: A 48-year-old woman was diagnosed with invasive breast cancer with ipsilateral metastases to axillary lymph nodes and a contralateral IMN metastasis. This case was presented twice during the tumor board sessions of the Surgical Oncology Service at the Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Canada. Question: Does the internal mammary chain (IMC) dissection could be used as a treatment approach in breast cancer with IMC metastasis? Conclusion: Internal mammary chain dissection should be discussed in tumor board sessions on a case-by-case basis. There are no strong guidelines on the management of IMN metastasis in breast cancer, but there is growing evidence that these women should be treated with curative intent.

Do All Women with Abnormal Sonographic Axillary Lymph Nodes Need a Biopsy?

2016 ◽  
Vol 67 (2) ◽  
pp. 173-178 ◽  
Author(s):  
Yoav Amitai ◽  
Tehillah Menes ◽  
Galit Aviram ◽  
Orit Golan
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Axillary Lymph Node ◽  
Needle Biopsy ◽  
Systemic Disease ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
History Of ◽  
Axillary Mass

Purpose With the increased use of breast ultrasound for different indications, sonographically abnormal axillary lymph nodes are not a rare finding. We examined clinical and imaging characteristics in correlation with pathological reports of the sonographic guided biopsies to assess the yield of needle biopsy of these nodes. Methods Clinical, imaging and pathology data were collected for 171 consecutive patients who underwent sonographic guided needle biopsy of an abnormal lymph node between 2008 and 2013. Malignancy rates were examined for different clinical settings: palpable axillary mass, previous history of breast cancer, findings suggestive of a systemic disease, and those with a breast finding of low suspicion or an incidental abnormal axillary lymph node. Patients with newly diagnosed breast cancer were excluded. Results Twelve patients (7%) were found to have a malignancy on their axillary lymph node biopsy. Malignancy rates increased with age, and varied with clinical presentation: Axillary mass (8, 26%); history of breast cancer (2, 11%); systemic disease (0%) and breast finding of low suspicion or incidental abnormal lymph node on screening (1, 1%). Low rates of malignancy were found when the cortex was <6 mm (1, 0.8%). The most important imaging finding associated with malignancy was lack of a preserved hilum, in which case almost a third (10, 29%) of the biopsies were malignant. Only 1 of 89 women with a breast finding of low suspicion or an incidental abnormal axillary lymph node was found to have malignancy. In this case the lymph node had no hilum. Conclusions In women without breast cancer, a highly suspicious breast mass or an axillary mass, more stringent criteria should be used when evaluating an abnormal axillary lymph node on sonography, as the malignancy rates are very low (1%).

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