scholarly journals CTLA4Ig inhibits T cell–dependent B-cell maturation in murine systemic lupus erythematosus

2000 ◽  
Vol 106 (1) ◽  
pp. 91-101 ◽  
Author(s):  
Masahiko Mihara ◽  
Irene Tan ◽  
Yelena Chuzhin ◽  
Bhoompally Reddy ◽  
Lalbachan Budhai ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cell ◽  
B Cell ◽  
Lupus Erythematosus ◽  
Cell Maturation ◽  
Systemic Lupus ◽  
B Cell Maturation ◽  
Murine Systemic Lupus Erythematosus

scholarly journals The Yaa Locus and IFN-α Fine-Tune Germinal Center B Cell Selection in Murine Systemic Lupus Erythematosus

2012 ◽  
Vol 189 (9) ◽  
pp. 4305-4312 ◽  
Author(s):  
Ioana Moisini ◽  
Weiqing Huang ◽  
Ramalingam Bethunaickan ◽  
Ranjit Sahu ◽  
Peta-Gay Ricketts ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
B Cell ◽  
Lupus Erythematosus ◽  
Germinal Center ◽  
Cell Selection ◽  
Systemic Lupus ◽  
Germinal Center B Cell ◽  
Murine Systemic Lupus Erythematosus ◽  
Fine Tune

scholarly journals Interferon-α accelerates murine systemic lupus erythematosus in a T cell-dependent manner

2010 ◽  
Vol 63 (1) ◽  
pp. 219-229 ◽  
Author(s):  
Zheng Liu ◽  
Ramalingam Bethunaickan ◽  
Weiqing Huang ◽  
Umairullah Lodhi ◽  
Ingrid Solano ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cell ◽  
Lupus Erythematosus ◽  
Interferon Α ◽  
Dependent Manner ◽  
Systemic Lupus ◽  
Murine Systemic Lupus Erythematosus

scholarly journals Decreased microRNA-142-3p/5p expression causes CD4+ T cell activation and B cell hyperstimulation in systemic lupus erythematosus

2012 ◽  
Vol 64 (9) ◽  
pp. 2953-2963 ◽  
Author(s):  
Shu Ding ◽  
Yunsheng Liang ◽  
Ming Zhao ◽  
Gongping Liang ◽  
Hai Long ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cell ◽  
B Cell ◽  
T Cell Activation ◽  
Lupus Erythematosus ◽  
Cell Activation ◽  
Cd4 T Cell ◽  
Systemic Lupus

scholarly journals Neutrophil-Mediated IFN Activation in the Bone Marrow Alters B Cell Development in Human and Murine Systemic Lupus Erythematosus

2013 ◽  
Vol 192 (3) ◽  
pp. 906-918 ◽  
Author(s):  
Arumugam Palanichamy ◽  
Jason W. Bauer ◽  
Srilakshmi Yalavarthi ◽  
Nida Meednu ◽  
Jennifer Barnard ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Bone Marrow ◽  
B Cell ◽  
Lupus Erythematosus ◽  
Cell Development ◽  
B Cell Development ◽  
Systemic Lupus ◽  
Murine Systemic Lupus Erythematosus

scholarly journals BNT162b2 vaccine-induced humoral and cellular responses against SARS-CoV-2 variants in Systemic Lupus Erythematosus

2021 ◽  
Author(s):  
Quentin Moyon ◽  
Delphine Sterlin ◽  
Makoto Miyara ◽  
Francois Anna ◽  
Alexis Mathian ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cell ◽  
Antibody Response ◽  
Disease Activity ◽  
B Cell ◽  
Lupus Erythematosus ◽  
Serum Levels ◽  
T Cell Response ◽  
Inactive Disease ◽  
Systemic Lupus

Objectives: Our aims were to evaluate Systemic Lupus Erythematosus (SLE) disease activity and SARS-CoV-2 specific immune responses after BNT162b2 vaccination. Methods: In this prospective study, disease activity and clinical assessments were recorded from the first dose of vaccine, until day 15 after the second dose in 126 SLE patients. SARS-CoV-2 antibody responses were measured against wild-type spike antigen while serum-neutralizing activity was assessed against the SARS-CoV-2 historical strain and variants of concerns (VOCs). Vaccine-specific T-cell responses were quantified by Interferon (IFN)-gamma; release assay after the second dose. Results: BNT162b2 was well tolerated and no statistically significant variations of BILAG and SLEDAI scores were observed throughout the study in SLE patients with active and inactive disease at baseline. Mycophenolate Mofetil (MMF) and Methotrexate (MTX) treatments were associated with drastically reduced BNT162b2 antibody-response (beta=-78; p=0.007, beta=-122; p<0.001, respectively). Anti-spike antibody response was positively associated with baseline total IgG serum levels, naive B cell frequencies (beta=2; p=0.018, beta=2.5; p=0.003) and SARS-CoV-2-specific T cell response (r=0.462; p=0.003). In responders, serum neutralization activity decreased against VOCs bearing the E484K mutation but remained detectable in a majority of patients. Conclusion: MMF, MTX and poor baseline humoral immune status, particularly: low naive B cell frequencies, are independently associated with impaired BNT162b2 mRNA antibody response, delineating SLE patients who might need adapted vaccine regimens and follow-up.

scholarly journals Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming

2013 ◽  
Vol 74 (2) ◽  
pp. 452-463 ◽  
Author(s):  
Khader Valli Rupanagudi ◽  
Onkar P Kulkarni ◽  
Julia Lichtnekert ◽  
Murthy Narayana Darisipudi ◽  
Shrikant R Mulay ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cell ◽  
Lupus Nephritis ◽  
B Cell ◽  
Mhc Class Ii ◽  
Lupus Erythematosus ◽  
Class Ii ◽  
Cd4 T Cell ◽  
Cathepsin S ◽  
Systemic Lupus
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