scholarly journals Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism

2016 ◽  
Vol 126 (11) ◽  
pp. 4387-4387 ◽  
Author(s):  
Cullen M. Taniguchi ◽  
Kohjiro Ueki ◽  
C. Ronald Kahn
Keyword(s):  
Regulation Of Metabolism ◽  
Hepatic Regulation

scholarly journals Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism

2005 ◽  
Vol 115 (5) ◽  
pp. 1388-1388
Author(s):  
Cullen M. Taniguchi ◽  
Kohjiro Ueki ◽  
C. Ronald Kahn
Keyword(s):  
Regulation Of Metabolism ◽  
Hepatic Regulation

scholarly journals Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism

2005 ◽  
Vol 115 (3) ◽  
pp. 718-727 ◽  
Author(s):  
Cullen M. Taniguchi ◽  
Kohjiro Ueki ◽  
C. Ronald Kahn
Keyword(s):  
Regulation Of Metabolism ◽  
Hepatic Regulation

scholarly journals Variation in hepatic regulation of metabolism during the dry period and in early lactation in dairy cows

2009 ◽  
Vol 92 (5) ◽  
pp. 1924-1940 ◽  
Author(s):  
H.A. van Dorland ◽  
S. Richter ◽  
I. Morel ◽  
M.G. Doherr ◽  
N. Castro ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Early Lactation ◽  
Dry Period ◽  
Regulation Of Metabolism ◽  
Hepatic Regulation

scholarly journals Distinct Changes in Gut Microbiota Are Associated with Estradiol-Mediated Protection from Diet-Induced Obesity in Female Mice

Metabolites ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 499
Author(s):  
Kalpana D. Acharya ◽  
Hye L. Noh ◽  
Madeline E. Graham ◽  
Sujin Suk ◽  
Randall H. Friedline ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Energy Homeostasis ◽  
Whole Body ◽  
Glucose Turnover ◽  
Female Mice ◽  
Adult Mice ◽  
Diet Induced Obesity ◽  
Metabolic Dysregulation ◽  
Regulation Of Metabolism ◽  
Junction Protein

A decrease in ovarian estrogens in postmenopausal women increases the risk of weight gain, cardiovascular disease, type 2 diabetes, and chronic inflammation. While it is known that gut microbiota regulates energy homeostasis, it is unclear if gut microbiota is associated with estradiol regulation of metabolism. In this study, we tested if estradiol-mediated protection from high-fat diet (HFD)-induced obesity and metabolic changes are associated with longitudinal alterations in gut microbiota in female mice. Ovariectomized adult mice with vehicle or estradiol (E2) implants were fed chow for two weeks and HFD for four weeks. As reported previously, E2 increased energy expenditure, physical activity, insulin sensitivity, and whole-body glucose turnover. Interestingly, E2 decreased the tight junction protein occludin, suggesting E2 affects gut epithelial integrity. Moreover, E2 increased Akkermansia and decreased Erysipleotrichaceae and Streptococcaceae. Furthermore, Coprobacillus and Lactococcus were positively correlated, while Akkermansia was negatively correlated, with body weight and fat mass. These results suggest that changes in gut epithelial barrier and specific gut microbiota contribute to E2-mediated protection against diet-induced obesity and metabolic dysregulation. These findings provide support for the gut microbiota as a therapeutic target for treating estrogen-dependent metabolic disorders in women.

scholarly journals Identification of the MuRF1 skeletal muscle ubiquitylome through quantitative proteomics

Function ◽  
2021 ◽  
Author(s):  
Leslie M Baehr ◽  
David C Hughes ◽  
Sarah A Lynch ◽  
Delphi Van Haver ◽  
Teresa Mendes Maia ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Atrophy ◽  
Potential Role ◽  
Ubiquitin Proteasome System ◽  
In Vivo Electroporation ◽  
Adult Mice ◽  
Expression Of Genes ◽  
Regulation Of Metabolism ◽  
Ubiquitin Proteasome

Abstract MuRF1 (TRIM63) is a muscle-specific E3 ubiquitin ligase and component of the ubiquitin proteasome system. MuRF1 is transcriptionally upregulated under conditions that cause muscle loss, in both rodents and humans, and is a recognized marker of muscle atrophy. In this study, we used in vivo electroporation to determine if MuRF1 overexpression alone can cause muscle atrophy and, in combination with ubiquitin proteomics, identify the endogenous MuRF1 substrates in skeletal muscle. Overexpression of MuRF1 in adult mice increases ubiquitination of myofibrillar and sarcoplasmic proteins, increases expression of genes associated with neuromuscular junction instability, and causes muscle atrophy. A total of 169 ubiquitination sites on 56 proteins were found to be regulated by MuRF1. MuRF1-mediated ubiquitination targeted both thick and thin filament contractile proteins, as well as, glycolytic enzymes, deubiquitinases, p62, and VCP. These data reveal a potential role for MuRF1 in not only the breakdown of the sarcomere, but also the regulation of metabolism and other proteolytic pathways in skeletal muscle.

scholarly journals Neurogenetic basis for circadian regulation of metabolism by the hypothalamus

2019 ◽  
Vol 33 (17-18) ◽  
pp. 1136-1158 ◽  
Author(s):  
Jonathan Cedernaes ◽  
Nathan Waldeck ◽  
Joseph Bass
Keyword(s):  
Circadian Regulation ◽  
Regulation Of Metabolism

scholarly journals Different Approaches in Therapy Aiming to Stabilize An Unstable Atherosclerotic Plaque

2021 ◽  
Vol 22 (9) ◽  
pp. 4354
Author(s):  
Michal Kowara ◽  
Agnieszka Cudnoch-Jedrzejewska
Keyword(s):  
Atherosclerotic Plaque ◽  
Clinical Problem ◽  
Myocardial Infarctions ◽  
Matrix Remodeling ◽  
Plaque Erosion ◽  
Plaque Stabilization ◽  
Regulation Of Metabolism ◽  
Alternative Approaches ◽  
Unstable Atherosclerotic Plaque ◽  
Plaque Destabilization

Atherosclerotic plaque vulnerability is a vital clinical problem as vulnerable plaques tend to rupture, which results in atherosclerosis complications—myocardial infarctions and subsequent cardiovascular deaths. Therefore, methods aiming to stabilize such plaques are in great demand. In this brief review, the idea of atherosclerotic plaque stabilization and five main approaches—towards the regulation of metabolism, macrophages and cellular death, inflammation, reactive oxygen species, and extracellular matrix remodeling have been presented. Moreover, apart from classical approaches (targeted at the general mechanisms of plaque destabilization), there are also alternative approaches targeted either at certain plaques which have just become vulnerable or targeted at the minimization of the consequences of atherosclerotic plaque erosion or rupture. These alternative approaches have also been briefly mentioned in this review.

scholarly journals Regulation of Metabolism in Working Muscle in Vivo

1966 ◽  
Vol 241 (3) ◽  
pp. 632-634
Author(s):  
Bertram Sacktor ◽  
Edward C. Hurlbut
Keyword(s):  
Regulation Of Metabolism
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