scholarly journals Estrogen receptor–α in medial amygdala neurons regulates body weight

2015 ◽  
Vol 125 (7) ◽  
pp. 2861-2876 ◽  
Author(s):  
Pingwen Xu ◽  
Xuehong Cao ◽  
Yanlin He ◽  
Liangru Zhu ◽  
Yongjie Yang ◽  
...  
Endocrinology ◽  
2016 ◽  
Vol 157 (10) ◽  
pp. 4021-4031 ◽  
Author(s):  
Shannon B. Z. Stephens ◽  
Navdeep Chahal ◽  
Nagambika Munaganuru ◽  
Ruby A. Parra ◽  
Alexander S. Kauffman

2011 ◽  
Vol 71 ◽  
pp. e164
Author(s):  
Mariko Nakata ◽  
Kazuhiro Sano ◽  
Mumeko C. Tsuda ◽  
Nandini Vasudevan ◽  
Sonoko Ogawa

Hypertension ◽  
2016 ◽  
Vol 67 (6) ◽  
pp. 1321-1330 ◽  
Author(s):  
Antentor Othrell Hinton ◽  
Yanlin He ◽  
Yan Xia ◽  
Pingwen Xu ◽  
Yongjie Yang ◽  
...  

2016 ◽  
Vol 113 (27) ◽  
pp. 7632-7637 ◽  
Author(s):  
Kazuhiro Sano ◽  
Mariko Nakata ◽  
Sergei Musatov ◽  
Masahiro Morishita ◽  
Toshiro Sakamoto ◽  
...  

Testosterone plays a central role in the facilitation of male-type social behaviors, such as sexual and aggressive behaviors, and the development of their neural bases in male mice. The action of testosterone via estrogen receptor (ER) α, after being aromatized to estradiol, has been suggested to be crucial for the full expression of these behaviors. We previously reported that silencing of ERα in adult male mice with the use of a virally mediated RNAi method in the medial preoptic area (MPOA) greatly reduced sexual behaviors without affecting aggressive behaviors whereas that in the medial amygdala (MeA) had no effect on either behavior. It is well accepted that testosterone stimulation during the pubertal period is necessary for the full expression of male-type social behaviors. However, it is still not known whether, and in which brain region, ERα is involved in this developmental effect of testosterone. In this study, we knocked down ERα in the MeA or MPOA in gonadally intact male mice at the age of 21 d and examined its effects on the sexual and aggressive behaviors later in adulthood. We found that the prepubertal knockdown of ERα in the MeA reduced both sexual and aggressive behaviors whereas that in the MPOA reduced only sexual, but not aggressive, behavior. Furthermore, the number of MeA neurons was reduced by prepubertal knockdown of ERα. These results indicate that ERα activation in the MeA during the pubertal period is crucial for male mice to fully express their male-type social behaviors in adulthood.


2010 ◽  
Vol 210 (2) ◽  
pp. 211-220 ◽  
Author(s):  
Thierry Spiteri ◽  
Sergei Musatov ◽  
Sonoko Ogawa ◽  
Ana Ribeiro ◽  
Donald W. Pfaff ◽  
...  

2004 ◽  
Vol 171 (4S) ◽  
pp. 348-348
Author(s):  
Ellen Shapiro ◽  
Hongying Huang ◽  
Rachael R. Mash ◽  
Eliza Ng ◽  
Deborah E. McFadden ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document