scholarly journals Essential amino acid supplementation in patients following total knee arthroplasty

2013 ◽  
Vol 123 (11) ◽  
pp. 4654-4666 ◽  
Author(s):  
Hans C. Dreyer ◽  
Lisa A. Strycker ◽  
Hilary A. Senesac ◽  
Austin D. Hocker ◽  
Keith Smolkowski ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Amino Acid ◽  
Knee Arthroplasty ◽  
Essential Amino Acid ◽  
Amino Acid Supplementation ◽  
Acid Supplementation ◽  
Total Knee

scholarly journals Essential Amino Acid Supplementation Mitigates Muscle Atrophy After Total Knee Arthroplasty

2018 ◽  
Vol 3 (2) ◽  
pp. e0006 ◽  
Author(s):  
Hans C. Dreyer ◽  
Erin C. Owen ◽  
Lisa A. Strycker ◽  
Keith Smolkowski ◽  
Jonathan B. Muyskens ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Amino Acid ◽  
Muscle Atrophy ◽  
Knee Arthroplasty ◽  
Essential Amino Acid ◽  
Amino Acid Supplementation ◽  
Acid Supplementation ◽  
Total Knee

scholarly journals Cellular and morphological changes with EAA supplementation before and after total knee arthroplasty

2019 ◽  
Vol 127 (2) ◽  
pp. 531-545 ◽  
Author(s):  
Jonathan B. Muyskens ◽  
Douglas M. Foote ◽  
Nathan J. Bigot ◽  
Lisa A. Strycker ◽  
Keith Smolkowski ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Muscle Atrophy ◽  
Satellite Cells ◽  
Knee Arthroplasty ◽  
Essential Amino Acid ◽  
Amino Acid Supplementation ◽  
Markers Of Inflammation ◽  
Tnf Α ◽  
Before And After ◽  
Total Knee

The purpose of this study was to investigate the underlying cellular basis of muscle atrophy (Placebo) and atrophy reduction (essential amino acid supplementation, EAAs) in total knee arthroplasty (TKA) patients by examining satellite cells and other key histological markers of inflammation, recovery, and fibrosis. Forty-one subjects (53–76 yr) scheduled for TKA were randomized into two groups, ingesting 20 g of EAAs or placebo, twice-daily, for 7 days before TKA and for 6 wk after surgery. A first set of muscle biopsies was obtained from both legs before surgery in the operating room, and patients were randomly assigned and equally allocated to have two additional biopsies at either 1 or 2 wk after surgery. Biopsies were processed for gene expression and immunohistochemistry. Satellite cells were significantly higher in patients ingesting 20 g of essential amino acids twice daily for the 7 days leading up to surgery compared with Placebo (operative leg P = 0.03 for satellite cells/fiber and P = 0.05 for satellite cell proportions for Type I-associated cells and P = 0.05 for satellite cells/fiber for Type II-associated cells.) Myogenic regulatory factor gene expression was different between groups, with the Placebo Group having elevated MyoD expression at 1 wk and EAAs having elevated myogenin expression at 1 wk. M1 macrophages were more prevalent in Placebo than the EAAs Group. IL-6 and TNF-α transcripts were elevated postsurgery in both groups; however, TNF-α declined by 2 wk in the EAAs Group. EAAs starting 7 days before surgery increased satellite cells on the day of surgery and promoted a more favorable inflammatory environment postsurgery. NEW & NOTEWORTHY Clinical studies by our group indicate that the majority of muscle atrophy after total knee arthroplasty (TKA) in older adults occurs rapidly, within the first 2 wks. We have also shown that essential amino acid supplementation (EAAs) before and after TKA mitigates muscle atrophy; however, the mechanisms are unknown. These results suggest that satellite cell numbers are elevated with EAA ingestion before surgery, and after surgery, EAA ingestion positively influences markers of inflammation. Combined, these data may help inform further studies designed to address the accelerated sarcopenia that occurs in older adults after major surgery.

Loss of Amino Acids during Hemodialysis: Effect of Oral Essential Amino Acid Supplementation

Nephron ◽  
1981 ◽  
Vol 29 (1-2) ◽  
pp. 25-29 ◽  
Author(s):  
T. Tepper ◽  
G.K. van der Hem ◽  
H.G. Klip ◽  
A.J.M. Donker
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Essential Amino Acid ◽  
Amino Acid Supplementation ◽  
Acid Supplementation

Effect of essential amino acid supplementation in acute renal failure

1995 ◽  
Vol 27 (4) ◽  
pp. 503-510 ◽  
Author(s):  
M. Z. Mocan ◽  
H. Mocan ◽  
M. N. Gacar ◽  
G. K. Özgür ◽  
M. H. Uluutku
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Amino Acid ◽  
Essential Amino Acid ◽  
Amino Acid Supplementation ◽  
Acid Supplementation

scholarly journals Essential Amino Acid Supplementation by Gut Microbes of a Wood-Feeding Cerambycid

2015 ◽  
Vol 45 (1) ◽  
pp. 66-73 ◽  
Author(s):  
Paul A. Ayayee ◽  
Thomas Larsen ◽  
Cristina Rosa ◽  
Gary W. Felton ◽  
James G. Ferry ◽  
...  
Keyword(s):  
Amino Acid ◽  
Essential Amino Acid ◽  
Amino Acid Supplementation ◽  
Acid Supplementation ◽  
Gut Microbes

scholarly journals Essential amino acid supplementation on muscle function and stair ascent/descent following 10 days of bed rest in older adults

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Brock Symons ◽  
Juan Lombeida ◽  
Elizabeth Protas ◽  
Patrick Kortebein ◽  
Douglas Paddon‐Jones ◽  
...  
Keyword(s):  
Older Adults ◽  
Amino Acid ◽  
Muscle Function ◽  
Essential Amino Acid ◽  
Bed Rest ◽  
Amino Acid Supplementation ◽  
Acid Supplementation ◽  
Stair Ascent

2020 Chitranjan S. Ranawat Award: Perioperative essential amino acid supplementation suppresses rectus femoris muscle atrophy and accelerates early functional recovery following total knee arthroplasty

2020 ◽  
Vol 102-B (6_Supple_A) ◽  
pp. 10-18 ◽  
Author(s):  
Hideki Ueyama ◽  
Narihiro Kanemoto ◽  
Yukihide Minoda ◽  
Yoshiki Taniguchi ◽  
Hiroaki Nakamura
Keyword(s):  
Amino Acid ◽  
Serum Albumin ◽  
Muscle Atrophy ◽  
Essential Amino Acid ◽  
Rectus Femoris ◽  
Amino Acid Supplementation ◽  
Muscle Area ◽  
Acid Supplementation ◽  
Rectus Femoris Muscle ◽  
Femoris Muscle

Aims The aim of this study was to assess the effectiveness of perioperative essential amino acid (EAA) supplementation to prevent rectus femoris muscle atrophy and facilitate early recovery of function after total knee arthroplasty (TKA). Methods The study involved 60 patients who underwent unilateral TKA for primary knee osteo-arthritis (OA). This was a double-blind, placebo-controlled, randomized control trial with patients randomly allocated to two groups, 30 patients each: the essential amino acid supplementation (9 g daily) and placebo (lactose powder, 9 g daily) groups. Supplementation and placebo were provided from one week before to two weeks after surgery. The area of the rectus femoris muscle were measured by ultrasound imaging one month before surgery and one, two, three, and four weeks postoperatively. The serum albumin level, a visual analogue knee pain score, and mobility were also measured at each time point. The time to recovery of activities of daily living (ADLs) was recorded. Postoperative nutrition and physiotherapy were identical in both groups. Results The mean relative change from baseline was as follows for the amino acid group: 116% in rectus femoris muscle area (71% to 206%); 95% in serum albumin (80% to 115%) and 39% in VAS pain (0% to 100%) at four weeks after surgery. These values in the placebo group were: 97% in muscle area (68 to 155); 89% in serum albumin (71% to 100%) and 56% in VAS pain four weeks after surgery (0% to 100%). All changes were statistically significant (p < 0.05). The mean time to recovery of ADLs was shorter in the amino acid group compared with the placebo group (p = 0.005). Conclusion Perioperative essential amino acid supplementation prevents rectus femoris muscle atrophy and accelerates early functional recovery after TKA. Cite this article: Bone Joint J 2020;102-B(6 Supple A):10–18.

scholarly journals Skeletal Muscle Acute and Chronic Metabolic Response to Essential Amino Acid Supplementation in Hypertriglyceridemic Older Adults

2017 ◽  
Vol 1 (11) ◽  
pp. e002071
Author(s):  
Bryce J Marquis ◽  
Nicholas M Hurren ◽  
Eugenia Carvalho ◽  
Il-Young Kim ◽  
Scott Schutzler ◽  
...  
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Amino Acid ◽  
Essential Amino Acid ◽  
Metabolic Response ◽  
Amino Acid Supplementation ◽  
Acid Supplementation
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