scholarly journals Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation

2012 ◽  
Vol 122 (12) ◽  
pp. 4748-4748
Author(s):  
Sofie Vandevyver ◽  
Lien Dejager ◽  
Tom Van Bogaert ◽  
Anna Kleyman ◽  
Yusen Liu ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Receptor Dimerization

scholarly journals Cognitive dysfunction in mice lacking proper glucocorticoid receptor dimerization

PLoS ONE ◽  
2019 ◽  
Vol 14 (12) ◽  
pp. e0226753
Author(s):  
Kelly Van Looveren ◽  
Michiel Van Boxelaere ◽  
Zsuzsanna Callaerts-Vegh ◽  
Claude Libert
Keyword(s):  
Glucocorticoid Receptor ◽  
Cognitive Dysfunction ◽  
Receptor Dimerization

scholarly journals Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition

Cell ◽  
2002 ◽  
Vol 110 (1) ◽  
pp. 93-105 ◽  
Author(s):  
Randy K. Bledsoe ◽  
Valerie G. Montana ◽  
Thomas B. Stanley ◽  
Chris J. Delves ◽  
Christopher J. Apolito ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Glucocorticoid Receptor ◽  
Ligand Binding ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Receptor Ligand ◽  
Receptor Dimerization

scholarly journals Glucocorticoid receptor dimerization is required for proper recovery of LPS-induced inflammation, sickness behavior and metabolism in mice

2012 ◽  
Vol 18 (9) ◽  
pp. 1006-1017 ◽  
Author(s):  
M N Silverman ◽  
P Mukhopadhyay ◽  
E Belyavskaya ◽  
L H Tonelli ◽  
B D Revenis ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Sickness Behavior ◽  
Receptor Dimerization

scholarly journals Glucocorticoid Receptor Condensates Link DNA-Dependent Receptor Dimerization and Transcriptional Transactivation

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A809-A809
Author(s):  
Filipp Frank ◽  
Xu Liu ◽  
Eric Ortlund
Keyword(s):  
Transcription Factor ◽  
Dna Binding ◽  
Glucocorticoid Receptor ◽  
Target Genes ◽  
Dna Recognition ◽  
Receptor Dimerization ◽  
Intrinsically Disordered ◽  
Intrinsically Disordered Regions ◽  
Recognition Elements

Abstract The glucocorticoid receptor (GR) is a ligand-regulated transcription factor (TF) that controls the tissue- and gene-specific transactivation and transrepression of thousands of target genes. Distinct GR DNA binding sequences with activating or repressive activities have been identified, but how they modulate transcription in opposite ways is not known. We show that GR forms phase-separated condensates that specifically concentrate known co-regulators via their intrinsically disordered regions (IDRs) in vitro. A combination of dynamic, multivalent (between IDRs) and specific, stable interactions (between LxxLL motifs and the GR ligand binding domain) control the degree of recruitment. Importantly, GR DNA-binding directs the selective partitioning of co-regulators within GR condensates such that activating DNAs cause enhanced recruitment of co-activators. Our work shows that condensation controls GR function by modulating co-regulator recruitment and provides a mechanism for the up- and down-regulation of GR target genes controlled by distinct DNA recognition elements.

[P1-170]: INHIBITING GLUCOCORTICOID RECEPTOR DIMERIZATION BLOCKS EFFECTS OF ACUTE STRESS ON Aβ IN FEMALE MICE

2017 ◽  
Vol 13 (7S_Part_6) ◽  
pp. P308-P309
Author(s):  
Carla M. Yuede ◽  
Clare E. Wallace ◽  
Hannah M. Edwards ◽  
Kayla M. Yuede ◽  
Todd A. Davis ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Acute Stress ◽  
Receptor Dimerization ◽  
Female Mice

scholarly journals Abrogation of Glucocorticoid Receptor Dimerization Correlates with Dissociated Glucocorticoid Behavior of Compound A

2009 ◽  
Vol 285 (11) ◽  
pp. 8061-8075 ◽  
Author(s):  
Steven Robertson ◽  
Fatima Allie-Reid ◽  
Wim Vanden Berghe ◽  
Koch Visser ◽  
Anke Binder ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Compound A ◽  
Receptor Dimerization

scholarly journals Impaired Glucocorticoid Receptor Dimerization Aggravates LPS-Induced Circulatory and Pulmonary Dysfunction

2020 ◽  
Vol 10 ◽  
Author(s):  
Martin Wepler ◽  
Jonathan M. Preuss ◽  
Tamara Merz ◽  
Clair Hartmann ◽  
Ulrich Wachter ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Pulmonary Dysfunction ◽  
Receptor Dimerization

scholarly journals Glucocorticoid receptor condensates link DNA-dependent receptor dimerization and transcriptional transactivation

2021 ◽  
Vol 118 (30) ◽  
pp. e2024685118
Author(s):  
Filipp Frank ◽  
Xu Liu ◽  
Eric A. Ortlund
Keyword(s):  
Transcription Factor ◽  
Dna Binding ◽  
Glucocorticoid Receptor ◽  
Target Genes ◽  
Dna Recognition ◽  
Receptor Dimerization ◽  
Intrinsically Disordered ◽  
Intrinsically Disordered Regions ◽  
Recognition Elements

The glucocorticoid receptor (GR) is a ligand-regulated transcription factor (TF) that controls the tissue- and gene-specific transactivation and transrepression of thousands of target genes. Distinct GR DNA-binding sequences with activating or repressive activities have been identified, but how they modulate transcription in opposite ways is not known. We show that GR forms phase-separated condensates that specifically concentrate known coregulators via their intrinsically disordered regions (IDRs) in vitro. A combination of dynamic, multivalent (between IDRs) and specific, stable interactions (between LxxLL motifs and the GR ligand-binding domain) control the degree of recruitment. Importantly, GR DNA binding directs the selective partitioning of coregulators within GR condensates such that activating DNAs cause enhanced recruitment of coactivators. Our work shows that condensation controls GR function by modulating coregulator recruitment and provides a mechanism for the up- and down-regulation of GR target genes controlled by distinct DNA recognition elements.

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