scholarly journals Cross-presentation and genome-wide screening reveal candidate T cells antigens for a herpes simplex virus type 1 vaccine

2012 ◽  
Vol 122 (8) ◽  
pp. 3024-3024 ◽  
Author(s):  
Lichen Jing ◽  
Jürgen Haas ◽  
Tiana M. Chong ◽  
Joseph J. Bruckner ◽  
Greg C. Dann ◽  
...  
Keyword(s):  
T Cells ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Cross Presentation ◽  
Genome Wide ◽  
Simplex Virus

scholarly journals Cross-presentation and genome-wide screening reveal candidate T cells antigens for a herpes simplex virus type 1 vaccine

2012 ◽  
Vol 122 (2) ◽  
pp. 654-673 ◽  
Author(s):  
Lichen Jing ◽  
Jürgen Haas ◽  
Tiana M. Chong ◽  
Joseph J. Bruckner ◽  
Greg C. Dann ◽  
...  
Keyword(s):  
T Cells ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Cross Presentation ◽  
Genome Wide ◽  
Simplex Virus

scholarly journals Genome-Wide Surveillance of Genital Herpes Simplex Virus Type 1 From Multiple Anatomic Sites Over Time

2018 ◽  
Vol 218 (4) ◽  
pp. 595-605 ◽  
Author(s):  
Mackenzie M Shipley ◽  
Daniel W Renner ◽  
Mariliis Ott ◽  
David C Bloom ◽  
David M Koelle ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Genital Herpes ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Genome Wide ◽  
Simplex Virus ◽  
Over Time

Pathogenic potentials of glycoprotein C-negative syncytial mutants from rabbit T cells infected persistently with herpes simplex virus type 1

2005 ◽  
Vol 76 (1) ◽  
pp. 89-97
Author(s):  
Yoshimasa Ishida ◽  
Tomoyuki Okabe ◽  
Yoshimi Azukizawa ◽  
Takahiro Isono ◽  
Akira Seto
Keyword(s):  
T Cells ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Glycoprotein C ◽  
Simplex Virus

scholarly journals Latency of herpes simplex virus type-1 in human geniculate and vestibular ganglia is associated with infiltration of CD8+ T cells

2010 ◽  
Vol 82 (11) ◽  
pp. 1917-1920 ◽  
Author(s):  
Viktor Arbusow ◽  
Tobias Derfuss ◽  
Kathrin Held ◽  
Susanne Himmelein ◽  
Michael Strupp ◽  
...  
Keyword(s):  
T Cells ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Cd8 T Cells ◽  
Herpes Simplex Virus Type ◽  
Simplex Virus

scholarly journals Virus-induced appearance of the selectin ligand sLeX in herpes simplex virus type 1-infected T-cells: Involvement of host and viral factors

Glycobiology ◽  
2012 ◽  
Vol 23 (3) ◽  
pp. 310-321 ◽  
Author(s):  
Rickard Nordén ◽  
Kristina Nyström ◽  
Johan Aurelius ◽  
Mikael Brisslert ◽  
Sigvard Olofsson
Keyword(s):  
T Cells ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Selectin Ligand ◽  
Simplex Virus

scholarly journals Genome-wide engineering of an infectious clone of herpes simplex virus type 1 using synthetic genomics assembly methods

2017 ◽  
Vol 114 (42) ◽  
pp. E8885-E8894 ◽  
Author(s):  
Lauren M. Oldfield ◽  
Peter Grzesik ◽  
Alexander A. Voorhies ◽  
Nina Alperovich ◽  
Derek MacMath ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Wild Type Virus ◽  
Genome Wide ◽  
Synthetic Genomics ◽  
Simplex Virus ◽  
Hsv 1

Here, we present a transformational approach to genome engineering of herpes simplex virus type 1 (HSV-1), which has a large DNA genome, using synthetic genomics tools. We believe this method will enable more rapid and complex modifications of HSV-1 and other large DNA viruses than previous technologies, facilitating many useful applications. Yeast transformation-associated recombination was used to clone 11 fragments comprising the HSV-1 strain KOS 152 kb genome. Using overlapping sequences between the adjacent pieces, we assembled the fragments into a complete virus genome in yeast, transferred it into anEscherichia colihost, and reconstituted infectious virus following transfection into mammalian cells. The virus derived from this yeast-assembled genome, KOSYA, replicated with kinetics similar to wild-type virus. We demonstrated the utility of this modular assembly technology by making numerous modifications to a single gene, making changes to two genes at the same time and, finally, generating individual and combinatorial deletions to a set of five conserved genes that encode virion structural proteins. While the ability to perform genome-wide editing through assembly methods in large DNA virus genomes raises dual-use concerns, we believe the incremental risks are outweighed by potential benefits. These include enhanced functional studies, generation of oncolytic virus vectors, development of delivery platforms of genes for vaccines or therapy, as well as more rapid development of countermeasures against potential biothreats.

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