scholarly journals Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism

2012 ◽  
Vol 122 (8) ◽  
pp. 2807-2816 ◽  
Author(s):  
Alanna Strong ◽  
Qiurong Ding ◽  
Andrew C. Edmondson ◽  
John S. Millar ◽  
Katherine V. Sachs ◽  
...  
Keyword(s):  
Apolipoprotein B ◽  
Ldl Catabolism

scholarly journals Delayed Low Density Lipoprotein (LDL) Catabolism Despite a Functional Intact LDL-Apolipoprotein B Particle and LDL-Receptor in a Subject with Clinical Homozygous Familial Hypercholesterolemia

1998 ◽  
Vol 83 (6) ◽  
pp. 2167-2174 ◽  
Author(s):  
Hartmut H.-J. Schmidt ◽  
Manfred Stuhrmann ◽  
Robert Shamburek ◽  
C. Knud Schewe ◽  
Margit Ebhardt ◽  
...  
Keyword(s):  
Familial Hypercholesterolemia ◽  
Apolipoprotein B ◽  
Receptor Gene ◽  
Low Density Lipoprotein ◽  
Ldl Receptor ◽  
Density Lipoprotein ◽  
Low Density ◽  
Homozygous Familial Hypercholesterolemia ◽  
Ldl Catabolism ◽  
Normal Controls

We identified a 38-yr-old male patient with the clinical expression of homozygous familial hypercholesterolemia presenting as severe coronary artery disease, tendon and skin xanthomas, arcus lipoides, and joint pain. The genetic trait seems to be autosomal recessive. Interestingly, serum concentrations of cholesterol responded well to diet and statins. We had no evidence of an abnormal low density lipoprotein (LDL)-apolipoprotein B (apoB) particle, which was isolated from the patient using the U937 proliferation assay as a functional test of the LDL-binding capacity. The apoB 3500 and apoB 3531 defects were ruled out by PCR. In addition, we found no evidence for a defect within the LDL-receptor by skin fibroblast analysis, linkage analysis, single-strand conformational polymorphism and Southern blot screening across the entire LDL-receptor gene. The in vivo kinetics of radioiodinated LDL-apoB were evaluated in the proband and three normal controls, subsequently. The LDL-apoB isolated from the patient showed a normal catabolism, confirming an intact LDL particle. In contrast the fractional catabolic rate (d−1) of autologous LDL in the subject and the normal controls revealed a remarkable delayed catabolism of the patient’s LDL (0.15 vs. 0.33–0.43 d−1). In addition, the elevation of LDL-cholesterol in the patient resulted from an increased production rate with 22.8 mg/kg per day vs. 12.7–15.7 mg/kg per day. These data indicate that there is another catabolic defect beyond the apoB and LDL-receptor gene causing familial hypercholesterolemia.

Regelmäßiger Walnussverzehr reduziert non-HDL-Cholesterin und Apolipoprotein-B bei gesunden Probanden

2013 ◽  
Vol 8 (S 01) ◽  
Author(s):  
L Wu ◽  
K Piotrowski ◽  
T Rau ◽  
E Waldmann ◽  
UC Brödl ◽  
...  
Keyword(s):  
Apolipoprotein B

Possible Functional Interactions of Apolipoprotein B-100 Segments That Associate With Cell Proteoglycans and the ApoB/E Receptor

1997 ◽  
Vol 17 (1) ◽  
pp. 149-155 ◽  
Author(s):  
Urban Olsson ◽  
Germán Camejo ◽  
Eva Hurt-Camejo ◽  
Karin Elfsber ◽  
Olof Wiklund ◽  
...  
Keyword(s):  
Apolipoprotein B ◽  
Functional Interactions

scholarly journals Interaction of 4-hydroxynonenal-modified low-density lipoproteins with the fibroblast apolipoprotein B/E receptor

1986 ◽  
Vol 234 (1) ◽  
pp. 245-248 ◽  
Author(s):  
W Jessup ◽  
G Jurgens ◽  
J Lang ◽  
H Esterbauer ◽  
R T Dean
Keyword(s):  
Apolipoprotein B ◽  
Negative Charge ◽  
Low Density Lipoprotein ◽  
Ldl Receptor ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipid Peroxidation Product ◽  
Modified Low Density Lipoproteins ◽  
Peroxidation Product

The incorporation of the lipid peroxidation product 4-hydroxynonenal into low-density lipoprotein (LDL) increases the negative charge of the particle, and decreases its affinity for the fibroblast LDL receptor. It is suggested that this modification may occur in vivo, and might promote atherogenesis.

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