scholarly journals Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer

2012 ◽  
Vol 122 (3) ◽  
pp. 1066-1075 ◽  
Author(s):  
Holbrook E. Kohrt ◽  
Roch Houot ◽  
Kipp Weiskopf ◽  
Matthew J. Goldstein ◽  
Ferenc Scheeren ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Specific Antibody ◽  
Killer Cells ◽  
Stimulation Of

scholarly journals Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer

2019 ◽  
Vol 129 (6) ◽  
pp. 2595-2595
Author(s):  
Holbrook E. Kohrt ◽  
Roch Houot ◽  
Kipp Weiskopf ◽  
Matthew J. Goldstein ◽  
Ferenc Scheeren ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Specific Antibody ◽  
Killer Cells ◽  
Stimulation Of

Nigella sativa and Cancer: A Review Focusing on Breast Cancer, Inhibition of Metastasis and Enhancement of Natural Killer Cell Cytotoxicity

2020 ◽  
Vol 21 (12) ◽  
pp. 1176-1185 ◽  
Author(s):  
Tuğcan Korak ◽  
Emel Ergül ◽  
Ali Sazci
Keyword(s):  
Breast Cancer ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Therapeutic Potential ◽  
Nigella Sativa ◽  
Killer Cell ◽  
B Cell Lymphoma ◽  
Killer Cells ◽  
Natural Killer Cell Cytotoxicity ◽  
Endothelial Growth Factor

Background: In the last decade, there have been accumulating data that the use of medicinal plants could bring additional benefits to the supportive treatment of various diseases. Nigella sativa (N. sativa, family Ranunculaceae) is one of these plants that has attracted considerable interest. The extracts and seeds of N. sativa and its active component thymoquinone have been studied extensively and the results suggest that N. sativa might carry some therapeutic potential for many diseases, including cancer. Methods: The selection criteria for references were applied through Pubmed with “N. sativa and cancer”, “N. sativa and breast cancer”, “N. sativa and metastasis”, “N. sativa and cytotoxicity of natural killer cells”. The pathway analysis was performed using the PANTHER tool by using five randomly selected N. sativa affected genes (Cyclin D1, P53, p21 protein (Cdc42/Rac) activated kinase 1 (PAK1), B-cell lymphoma 2 (Bcl-2) and vascular endothelial growth factor (VEGF)) in order to elucidate further potentially affected signaling pathways. Results: The aim of this review was to summarize studies regarding the effects of N. sativa in cancer generally, with a focus on breast cancer, its anti-metastatic effects, and how N. sativa modulates the cytotoxicity of Natural Killer cells that play a crucial role in tumor surveillance. Conclusion: In summary, the data suggest that N. sativa might be used for its anti-cancer and antimetastatic properties and as an immune system activator against cancer.

Natural killer cells in breast cancer cell growth and metastasis in SCID mice

2005 ◽  
Vol 59 ◽  
pp. S375-S379 ◽  
Author(s):  
Md.Z. Dewan ◽  
H. Terunuma ◽  
S. Ahmed ◽  
K. Ohba ◽  
M. Takada ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Scid Mice ◽  
Cancer Cell Growth ◽  
Killer Cells ◽  
Breast Cancer Cell Growth

scholarly journals Comparison of autogeneic and allogeneic natural killer cells immunotherapy on the clinical outcome of recurrent breast cancer

2017 ◽  
Vol Volume 10 ◽  
pp. 4273-4281 ◽  
Author(s):  
Shuzhen Liang ◽  
Kecheng Xu ◽  
Lizhi Niu ◽  
Xiaohua Wang ◽  
Yingqing Liang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Natural Killer Cells ◽  
Clinical Outcome ◽  
Natural Killer ◽  
Recurrent Breast Cancer ◽  
Killer Cells ◽  
Recurrent Breast
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