scholarly journals Synovium as a source of increased amino-terminal parathyroid hormone-related protein expression in rheumatoid arthritis. A possible role for locally produced parathyroid hormone-related protein in the pathogenesis of rheumatoid arthritis.

1998 ◽  
Vol 101 (7) ◽  
pp. 1362-1371 ◽  
Author(s):  
J L Funk ◽  
L A Cordaro ◽  
H Wei ◽  
J B Benjamin ◽  
D E Yocum
Keyword(s):  
Rheumatoid Arthritis ◽  
Parathyroid Hormone ◽  
Protein Expression ◽  
Related Protein ◽  
Amino Terminal ◽  
Parathyroid Hormone Related Protein

Parathyroid hormone-related protein expression is correlated with clinical course in patients with glial tumors

Cancer ◽  
2004 ◽  
Vol 101 (11) ◽  
pp. 2622-2628 ◽  
Author(s):  
Francisco S. Pardo ◽  
Winston W. Lien ◽  
Howard S. Fox ◽  
Jimmy T. Efird ◽  
Joseph A. Aguilera ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Protein Expression ◽  
Clinical Course ◽  
Related Protein ◽  
Glial Tumors ◽  
Parathyroid Hormone Related Protein

CYCLOSPORINE INCREASES RENAL PARATHYROID HORMONE-RELATED PROTEIN EXPRESSION IN VIVO IN THE RAT1

1998 ◽  
Vol 65 (6) ◽  
pp. 860-863 ◽  
Author(s):  
Adolfo Garcia-Oca??a ◽  
Elena Gomez-Casero ◽  
Carlos Pe??aranda ◽  
Jose Luis Sarasa ◽  
Pedro Esbrit
Keyword(s):  
Parathyroid Hormone ◽  
Protein Expression ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein

LDL induces parathyroid hormone-related protein expression in vascular smooth muscle cells: Modulation by simvastatin

2008 ◽  
Vol 198 (2) ◽  
pp. 264-271 ◽  
Author(s):  
Jose Luis Martin-Ventura ◽  
Luis Miguel Blanco-Colio ◽  
Cesar Aparicio ◽  
Luis Ortega ◽  
Pedro Esbrit ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Parathyroid Hormone ◽  
Vascular Smooth Muscle ◽  
Protein Expression ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein

Circulating levels of immunoreactive parathyroid hormone-related protein and intact parathyroid hormone in human fetuses and newborns

1996 ◽  
Vol 134 (4) ◽  
pp. 437-442 ◽  
Author(s):  
Nicholas E Papantoniou ◽  
Peter D Papapetrou ◽  
Aristidis J Antsaklis ◽  
Panayotis E Kontoleon ◽  
Spyros A Mesogitis ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Reproductive Age ◽  
Fetal Life ◽  
Intact Parathyroid Hormone ◽  
Human Fetuses ◽  
Related Protein ◽  
Amino Terminal ◽  
Parathyroid Hormone Related Protein ◽  
Circulating Levels ◽  
Immunoreactive Parathyroid Hormone

Papantoniou NE, Papapetrou PD, Antsaklis AJ, Kontoleon PE, Mesogitis SA, Aravantinos D. Circulating levels of immunoreactive parathyroid hormone-related protein and intact parathyroid hormone in human fetuses and newborns. Eur J Endocrinol 1996;134:437–42. ISSN 0804–4643 Undetectable or extremely low levels of circulating immunoreactive parathyroid hormone (PTH) have been reported in human newborns while PTH bioactivity was high. This prompted the hypothesis that the fetal calcemic hormone might be PTH-related protein. The purpose of this study was to measure circulating immunoreactive PTH-related protein in human fetuses and newborns in order to investigate this hypothesis. Parathyroid hormone-related protein (PTHrP(1–86)) and intact PTH were measured using two-site immunoradiometric assays in plasma obtained by cordocentesis from 23 fetuses (19–33 weeks of gestation), from 17 newborns at term (38–41 weeks), from their mothers and from 22 normal women of reproductive age. Plasma PTHrP was detectable in all but one of the fetuses and newborns and in all the mothers and the controls. The mean level was similar among fetuses (19–33 weeks) (0.43 ± 0.18 pmol/l), newborns (0.48 ±0.12), mothers (0.48 ±0.14) and normal controls (0.46 ± 0.09). Plasma PTH was found to be significantly higher in fetuses at midgestation (1.0 ± 0.99 pmol/l) than in the newborns (0.22 ± 0.21) (p < 0.0025); maternal PTH was significantly higher compared to fetal level at mid-gestation (2.1 ± 1.0, p < 0.01) as well as at term (2.69 ± 1.40, p < 0.001). In the control women PTH was 3.07 ± 1.25 pmol/l. These results showed that plasma amino-terminal PTHrP-(1–86)) is detectable during the second half of human fetal life and its level remains unchanged during this period of time, in contrast to changing levels of fetal plasma PTH. The relatively low PTHrP-(1–86) level that we found in the newborns is not responsible for the high PTH-like bioactivity found by some investigators in cord blood at term. Peter D Papapetrou, Second Division of Endocrinology, "Alexandra" Hospital, 80 Vas. Sofias & Lourou Streets, Athens 115 28, Greece

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