scholarly journals Modulation of subthalamic T-type Ca2+ channels remedies locomotor deficits in a rat model of Parkinson disease

2011 ◽  
Vol 121 (8) ◽  
pp. 3289-3305 ◽  
Author(s):  
Chun-Hwei Tai ◽  
Ya-Chin Yang ◽  
Ming-Kai Pan ◽  
Chen-Syuan Huang ◽  
Chung-Chin Kuo
Keyword(s):  
Parkinson Disease ◽  
Rat Model ◽  
Locomotor Deficits ◽  
Ca2 Channels

scholarly journals Laryngeal muscle biology in thePink1−/−rat model of Parkinson disease

2019 ◽  
Vol 126 (5) ◽  
pp. 1326-1334 ◽  
Author(s):  
Tiffany J. Glass ◽  
Cynthia A. Kelm-Nelson ◽  
John A. Russell ◽  
John C. Szot ◽  
Jacob M. Lake ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Rat Model ◽  
Force Production ◽  
Laryngeal Function ◽  
Laryngeal Muscle ◽  
Myosin Heavy Chain Isoform ◽  
Section Size ◽  
Neural Cell Adhesion ◽  
Muscle Biology ◽  
Locomotor Deficits

Neuromuscular pathology is found in the larynx and pharynx in humans with Parkinson disease (PD); however, it is unknown when this pathology emerges. We hypothesized that pathology occurs in early (premanifest) stages. To address this, we used the Pink1−/− rat model of PD, which shows age-dependent dopaminergic neuron loss, locomotor deficits, and deficits related to laryngeal function. We report findings in the thyroarytenoid muscle (TA) in Pink1−/− rats compared with wild-type (WT) control rats at 4 and 6 mo of age. TAs were analyzed for force production, myosin heavy chain isoform (MyHC), centrally nucleated myofibers, neural cell adhesion molecule, myofiber size, and muscle section size. Compared with WT, Pink1−/− TA had reductions in force levels at 1-Hz stimulation and 20-Hz stimulation, increases in relative levels of MyHC 2L, increases in incidence of centrally nucleated myofibers in the external division of the TA, and reductions in myofiber size of the vocalis division of the TA at 6 mo of age. Alterations of laryngeal muscle biology occur in a rat model of premanifest PD. Although these alterations are statistically significant, their functional significance remains to be determined.NEW & NOTEWORTHY Pathology of peripheral nerves and muscle has been reported in the larynx and pharynx of humans diagnosed with Parkinson disease (PD); however, it is unknown whether differences of laryngeal muscle occur at premanifest stages. This study examined the thyroarytenoid muscles of the Pink1−/− rat model of PD for differences of muscle biology compared with control rats. Thyroarytenoid muscles of Pink1−/− rats at premanifest stages show differences in multiple measures of muscle biology.

scholarly journals Atp13a2 expression in the periaqueductal gray is decreased in the Pink1 -/- rat model of Parkinson disease

2016 ◽  
Vol 621 ◽  
pp. 75-82 ◽  
Author(s):  
Cynthia A. Kelm-Nelson ◽  
Sharon A. Stevenson ◽  
Michelle R. Ciucci
Keyword(s):  
Parkinson Disease ◽  
Rat Model ◽  
Periaqueductal Gray

scholarly journals Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease

2011 ◽  
Vol 121 (6) ◽  
pp. 2326-2335 ◽  
Author(s):  
Yong-Hee Rhee ◽  
Ji-Yun Ko ◽  
Mi-Yoon Chang ◽  
Sang-Hoon Yi ◽  
Dohoon Kim ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Rat Model ◽  
Ips Cells ◽  
Dopamine Neurons ◽  
Generate Functional ◽  
Human Ips Cells

scholarly journals Intervention changes acoustic peak frequency and mesolimbic neurochemistry in the Pink1-/- rat model of Parkinson disease

PLoS ONE ◽  
2019 ◽  
Vol 14 (8) ◽  
pp. e0220734 ◽  
Author(s):  
Sharon A. Stevenson ◽  
Michelle R. Ciucci ◽  
Cynthia A. Kelm-Nelson
Keyword(s):  
Parkinson Disease ◽  
Rat Model ◽  
Peak Frequency

scholarly journals α-Synuclein S129 Phosphorylation Mutants Do Not Alter Nigrostriatal Toxicity in a Rat Model of Parkinson Disease

2009 ◽  
Vol 68 (5) ◽  
pp. 515-524 ◽  
Author(s):  
Nikolaus R. McFarland ◽  
Zhanyun Fan ◽  
Kui Xu ◽  
Michael A. Schwarzschild ◽  
Mel B. Feany ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Rat Model

scholarly journals Brain Arachidonic Acid Cascade Enzymes are Upregulated in a Rat Model of Unilateral Parkinson Disease

2009 ◽  
Vol 35 (4) ◽  
pp. 613-619 ◽  
Author(s):  
Ho-Joo Lee ◽  
Richard P. Bazinet ◽  
Stanley I. Rapoport ◽  
Abesh Kumar Bhattacharjee
Keyword(s):  
Arachidonic Acid ◽  
Parkinson Disease ◽  
Rat Model ◽  
Arachidonic Acid Cascade

Expression of FasL and its interaction with Fas are mediated by c-Jun N-terminal kinase (JNK) pathway in 6-OHDA-induced rat model of Parkinson disease

2007 ◽  
Vol 428 (2-3) ◽  
pp. 82-87 ◽  
Author(s):  
Jing Pan ◽  
Yan-xin Zhao ◽  
Zhi-Quan Wang ◽  
Lei Jin ◽  
Zhi-Kun Sun ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Rat Model ◽  
Jnk Pathway

Comparison of the therapeutic potential of adult and embryonic neural precursor cells in a rat model of Parkinson disease

2008 ◽  
Vol 108 (1) ◽  
pp. 149-159 ◽  
Author(s):  
Kenichiro Muraoka ◽  
Tetsuro Shingo ◽  
Takao Yasuhara ◽  
Masahiro Kameda ◽  
Wen Ji Yuen ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Rat Model ◽  
Fluorescent Protein ◽  
Therapeutic Potential ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Therapeutic Effects ◽  
Adenoviral Infection

Object The therapeutic effects of adult and embryonic neural precursor cells (NPCs) were evaluated and their therapeutic potential compared in a rat model of Parkinson disease. Methods Adult NPCs were obtained from the subventricular zone and embryonic NPCs were taken from the ganglionic eminence of 14-day-old embryos. Each NPC type was cultured with epidermal growth factor. The in vitro neuronal differentiation rate of adult NPCs was approximately equivalent to that of embryonic NPCs after two passages. Next, the NPCs were transfected with either green fluorescent protein or glial cell line–derived neurotrophic factor (GDNF) by adenoviral infection and transplanted into the striata in a rat model of Parkinson disease (PD) induced by unilateral intrastriatal injection of 6-hydroxydopamine. An amphetamine-induced rotation test was used to evaluate rat behavioral improvement, and immunohistochemical analysis was performed to compare grafted cell survival, differentiation, and host tissue changes. Results The rats with GDNF-transfected NPCs had significantly fewer amphetamine-induced rotations and less histological damage. Except for the proportion of surviving grafted cells, there were no significant differences between adult and embryonic NPCs. Conclusions Adult and embryonic NPCs have a comparable therapeutic potential in a rat model of PD.

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