scholarly journals Dynamics of insulin secretion and the clinical implications for obesity and diabetes

2011 ◽  
Vol 121 (6) ◽  
pp. 2118-2125 ◽  
Author(s):  
Susumu Seino ◽  
Tadao Shibasaki ◽  
Kohtaro Minami
Keyword(s):  
Insulin Secretion ◽  
Clinical Implications ◽  
Obesity And Diabetes ◽  
Dynamics Of Insulin Secretion

Effect of somatostatin-28 on dynamics of insulin secretion in perfused rat pancreas

Diabetes ◽  
1991 ◽  
Vol 40 (9) ◽  
pp. 1163-1169 ◽  
Author(s):  
J. W. Ensinck ◽  
E. C. Laschansky ◽  
R. E. Vogel ◽  
D. A. D'Alessio
Keyword(s):  
Insulin Secretion ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Dynamics Of Insulin Secretion

Diabetes mellitus in pheochromocytoma and paraganglioma: Prevalence, dynamics of insulin secretion / sensitivity and predictors of remission

2020 ◽  
Vol 14 (6) ◽  
pp. 2169-2175
Author(s):  
Saurav Khatiwada ◽  
Shipra Agarwal ◽  
Devasenathipathy Kandasamy ◽  
V.P. Jyotsna ◽  
Rajeev Kumar ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
Dynamics Of Insulin Secretion

scholarly journals PWD/PhJ and WSB/EiJ Mice Are Resistant to Diet-Induced Obesity But Have Abnormal Insulin Secretion

Endocrinology ◽  
2011 ◽  
Vol 152 (8) ◽  
pp. 3005-3017 ◽  
Author(s):  
Katie T. Y. Lee ◽  
Subashini Karunakaran ◽  
Maggie M. Ho ◽  
Susanne M. Clee
Keyword(s):  
Insulin Secretion ◽  
Insulin Sensitivity ◽  
Large Scale ◽  
Mouse Strains ◽  
Second Phase ◽  
Fasting Insulin ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Obesity And Diabetes

Recently, novel inbred mouse strains that are genetically distinct from the commonly used models have been developed from wild-caught mice. These wild-derived inbred strains have been included in many of the large-scale genomic projects, but their potential as models of altered obesity and diabetes susceptibility has not been assessed. We examined obesity and diabetes-related traits in response to high-fat feeding in two of these strains, PWD/PhJ (PWD) and WSB/EiJ (WSB), in comparison with C57BL/6J (B6). Young PWD mice displayed high fasting insulin levels, although they had normal insulin sensitivity. PWD mice subsequently developed a much milder and delayed-onset obesity compared with B6 mice but became as insulin resistant. PWD mice had a robust first-phase and increased second-phase glucose-stimulated insulin secretion in vivo, rendering them more glucose tolerant. WSB mice were remarkably resistant to diet-induced obesity and maintained very low fasting insulin throughout the study. WSB mice exhibited more rapid glucose clearance in response to an insulin challenge compared with B6 mice, consistent with their low percent body fat. Interestingly, in the absence of a measurable in vivo insulin secretion, glucose tolerance of WSB mice was better than B6 mice, likely due to their enhanced insulin sensitivity. Thus PWD and WSB are two obesity-resistant strains with unique insulin secretion phenotypes. PWD mice are an interesting model that dissociates hyperinsulinemia from obesity and insulin resistance, whereas WSB mice are a model of extraordinary resistance to a high-fat diet.

Dynamics of Insulin Secretion by the Perfused Rat Pancreas

Endocrinology ◽  
1968 ◽  
Vol 83 (3) ◽  
pp. 572-584 ◽  
Author(s):  
DONALD L. CURRY ◽  
LESLIE L. BENNETT ◽  
GEROLD M. GRODSKY
Keyword(s):  
Insulin Secretion ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Dynamics Of Insulin Secretion

Different dynamics of insulin secretion in the perfused pancreas of mouse and rat

1980 ◽  
Vol 93 (1) ◽  
pp. 54-60 ◽  
Author(s):  
Ove Berglund
Keyword(s):  
Insulin Secretion ◽  
Insulin Release ◽  
Glucose Concentration ◽  
Inbred Mice ◽  
Second Phase ◽  
Perfused Pancreas ◽  
First Response ◽  
Dynamics Of Insulin Secretion ◽  
Rats And Mice ◽  
Secretory Pattern

Abstract. The dynamics of insulin release were studied in the perfused pancreas of rats and mice. Perfusion of the rat pancreas with 20 mm D-glucose resulted in the classical biphasic release of insulin with a rising second phase. However, in normal C57BL/KsJ-mice and noninbred mice, whether fed or starved, the second phase was nearly constant. The secretory dymanics of KsJ-mice were essentially the same, whether the glucose concentration was 30 or 20 mm, whether the medium contained 2.56 or 8 mm Ca2+, and whether or not the medium was supplemented with 5 mm pyruvate, 5 mm glutamate, and 5 mm fumarate. Insulin secretion in these mice was almost totally inhibited by omission of Ca2+, and was markedly enhanced by 3-isobutyl-1-methylxanthine. Insulin release during the constant phase was reversed by lowering the glucose concentration. A second rise of glucose from 3 to 20 mm produced a secretory pattern very similar to the first response. These studies indicate that the dynamics of insulin secretion are somewhat different in rats and mice. Since similar results were obtained with C57BL/KsJ-mice and non-inbred mice, the liability of KsJ-mice to develop β-cell failure when stressed by the mutated db gene is not related to the constancy of the second insulin secretory phase.

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