scholarly journals Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents

2010 ◽  
Vol 120 (1) ◽  
pp. 369-378 ◽  
Author(s):  
Brian W. Jarecki ◽  
Andrew D. Piekarz ◽  
James O. Jackson ◽  
Theodore R. Cummins
Keyword(s):  
Sodium Channel ◽  
Sodium Currents ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated ◽  
Resurgent Sodium Currents

A series-parallel model of the voltage-gated sodium channel

1990 ◽  
Vol 240 (1299) ◽  
pp. 425-432 ◽  
Keyword(s):  
Molecular Structure ◽  
Sodium Channel ◽  
Giant Axon ◽  
Squid Giant Axon ◽  
Parallel Model ◽  
Sodium Currents ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated ◽  
Kinetics Of

A series-parallel model of the kinetics of the voltage-gated sodium channel is described. It goes some way towards reconciling the timecourses of the gating and macroscopic sodium currents in the squid giant axon with the molecular structure of the channel.

scholarly journals Life Cycle of the Cardiac Voltage-Gated Sodium Channel NaV1.5

2020 ◽  
Vol 11 ◽  
Author(s):  
Caijuan Dong ◽  
Ya Wang ◽  
Aiqun Ma ◽  
Tingzhong Wang
Keyword(s):  
Endoplasmic Reticulum ◽  
Sodium Channel ◽  
Membrane Microdomains ◽  
Sodium Currents ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated ◽  
Normal Functions ◽  
Complex Processes ◽  
Protein Partners ◽  
Target Membrane

Cardiac voltage-gated sodium channel NaV1.5, encoded by SCN5A, is crucial for the upstroke of action potential and excitation of cardiomyocytes. NaV1.5 undergoes complex processes before it reaches the target membrane microdomains and performs normal functions. A variety of protein partners are needed to achieve the balance between SCN5A transcription and mRNA decay, endoplasmic reticulum retention and export, Golgi apparatus retention and export, selective anchoring and degradation, activation, and inactivation of sodium currents. Subtle alterations can impair NaV1.5 in terms of expression or function, eventually leading to NaV1.5-associated diseases such as lethal arrhythmias and cardiomyopathy.

The Voltage-Gated Sodium Channel Nav1.2 Contributes to Neurodegeneration in an Animal Model of Multiple Sclerosis

2016 ◽  
Vol 47 (S 01) ◽  
Author(s):  
W. Fazeli ◽  
B. Schattling ◽  
B. Engeland ◽  
M. Friese ◽  
D. Isbrand
Keyword(s):  
Multiple Sclerosis ◽  
Animal Model ◽  
Sodium Channel ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated

Homozygous SCN1B variants causing early infantile epileptic encephalopathy 52 affect voltage‐gated sodium channel function

Epilepsia ◽  
2021 ◽  
Author(s):  
Marcello Scala ◽  
Stephanie Efthymiou ◽  
Tipu Sultan ◽  
Jolien De Waele ◽  
Marta Panciroli ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Epileptic Encephalopathy ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated ◽  
Channel Function
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