scholarly journals Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance

2010 ◽  
Vol 120 (4) ◽  
pp. 1310-1323 ◽  
Author(s):  
Laura Bonapace ◽  
Beat C. Bornhauser ◽  
Maike Schmitz ◽  
Gunnar Cario ◽  
Urs Ziegler ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Glucocorticoid Resistance ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Leukemia Cells

Zebularine induces chemosensitization to methotrexate and efficiently decreases AhR gene methylation in childhood acute lymphoblastic leukemia cells

2014 ◽  
Vol 25 (1) ◽  
pp. 72-81 ◽  
Author(s):  
Augusto F. Andrade ◽  
Kleiton S. Borges ◽  
Angel M. Castro-Gamero ◽  
Vanessa S. Silveira ◽  
Veridiana K. Suazo ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Gene Methylation ◽  
Ahr Gene

scholarly journals BAG3 Protein Regulates Cell Survival in Childhood Acute Lymphoblastic Leukemia Cells

2003 ◽  
Vol 2 (5) ◽  
pp. 508-510 ◽  
Author(s):  
Maria Fiammetta Romano ◽  
Michelina Festa ◽  
Antonello Petrella ◽  
Maria Pascale ◽  
Rita Bisogni ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Cell Survival ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Leukemia Cells

In vivo production of childhood acute lymphoblastic leukemia cells in relation to ploidy and immunological subtype

1984 ◽  
Vol 8 (4) ◽  
pp. 587-595 ◽  
Author(s):  
Peter Dörmer ◽  
Giovanni Ucci ◽  
Barbara Lau ◽  
Rainer J. Haas ◽  
Gritta E. Janka
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Leukemia Cells

Dexamethasone resistance in B-cell precursor childhood acute lymphoblastic leukemia occurs downstream of ligand-induced nuclear translocation of the glucocorticoid receptor

Blood ◽  
2005 ◽  
Vol 105 (6) ◽  
pp. 2519-2526 ◽  
Author(s):  
Petra S. Bachmann ◽  
Rosemary Gorman ◽  
Karen L. MacKenzie ◽  
Louise Lutze-Mann ◽  
Richard B. Lock
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Glucocorticoid Receptor ◽  
B Cell ◽  
Nuclear Translocation ◽  
Lymphoblastic Leukemia ◽  
Glucocorticoid Resistance ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Cell Precursor ◽  
Childhood All ◽  
Dexamethasone Resistance

AbstractGlucocorticoids are among the most effective agents used in the treatment of childhood acute lymphoblastic leukemia (ALL), and patient response to treatment is an important determinant of long-term outcome. Despite its clinical significance, the molecular basis of glucocorticoid resistance in lymphoid malignancies is still poorly understood. We have recently developed a highly clinically relevant experimental model of childhood ALL, in which primary childhood ALL biopsies were established as xenografts in nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice. The in vivo and in vitro responses of a panel of these xenografts to the glucocorticoid, dexamethasone, reflected the outcome of the patients from whom they were derived. In this report we show that glucocorticoid resistance in B-cell precursor (BCP) ALL xenografts was not due to down-regulation of the glucocorticoid receptor (GR) nor to defective ligand binding of the GR. Moreover, dexamethasone-induced GR translocation from the cytoplasm to the nucleus was comparable in all xenografts. However, glucocorticoid resistance was associated with profoundly attenuated induction of the BH3-only proapoptotic protein, Bim, when xenograft cells were exposed to dexamethasone. These results show that dexamethasone resistance in BCP ALL xenografts occurs downstream of ligand-induced nuclear translocation of the GR, but upstream of Bim induction.

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