scholarly journals Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer

2009 ◽  
Author(s):  
Lucia Regales ◽  
Yixuan Gong ◽  
Ronglai Shen ◽  
Elisa de Stanchina ◽  
Igor Vivanco ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Mouse Models ◽  
Resistance Mutation ◽  
Drug Resistance Mutation ◽  
Dual Targeting ◽  
Egfr Mutant ◽  
Major Drug

Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR

2005 ◽  
Vol 37 (12) ◽  
pp. 1315-1316 ◽  
Author(s):  
Daphne W Bell ◽  
Ira Gore ◽  
Ross A Okimoto ◽  
Nadia Godin-Heymann ◽  
Raffaella Sordella ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Resistance Mutation ◽  
Drug Resistance Mutation ◽  
Inherited Susceptibility

scholarly journals Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap–Core Interface of HIV-1 Protease

ACS Omega ◽  
2018 ◽  
Vol 3 (9) ◽  
pp. 12132-12140 ◽  
Author(s):  
Andres Wong-Sam ◽  
Yuan-Fang Wang ◽  
Ying Zhang ◽  
Arun K. Ghosh ◽  
Robert W. Harrison ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Resistance Mutation ◽  
Drug Resistance Mutation ◽  
Hiv 1

scholarly journals Cetuximab-modified mesoporous silica nano-medicine specifically targets EGFR-mutant lung cancer and overcomes drug resistance

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yuetong Wang ◽  
Hsin-Yi Huang ◽  
Liu Yang ◽  
Zhanxia Zhang ◽  
Hongbin Ji
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Mesoporous Silica ◽  
Egfr Mutant ◽  
Nano Medicine

scholarly journals Monitoring of HIV Drug Resistance Mutations in Newly Diagnosed Patients in Cyprus (2010–2012)

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S424-S424
Author(s):  
Ioannis Demetriades
Keyword(s):  
Drug Resistance ◽  
Phylogenetic Trees ◽  
Resistance Mutation ◽  
Drug Resistance Mutation ◽  
High Rate ◽  
Resistance Testing ◽  
Newly Diagnosed ◽  
Resistance Mutations ◽  
Subtype B ◽  
Hiv 1

Abstract Background A molecular epidemiology study of HIV-1 infection was conducted in 100 HIV-1 diagnosed and untreated patients in Cyprus representing 65.4 percent of all the reported HIV-1 infections in Cyprus between 2010 and 2012. Methods Eighty-two patients were newly diagnosed (genotypic drug resistance testing within six months from diagnosis), and 18 patients were HIV-1 diagnosed for a longer period or the diagnosis date was unknown. Results Phylogenetic trees of the pol sequences obtained in this study with reference sequences indicated that subtypes B and A1 were the most common subtypes present and accounted for 41.0 and 19.0% respectively, followed by subtype C (7.0%), F1 (8.0%), CRF02_AG (4.0%), A2 (2.0%), other CRFs (7.0%) and unknown recombinant forms, URFs (12%). Most of newly-diagnosed study subjects were Cypriots (63%), males (78%) with median age 39 (Interquartile Range, IQR 33–48) reporting having sex with other men, MSM (51%). Conclusion A high rate of clustered transmission of subtype B drug-sensitive strains to reverse transcriptase and protease inhibitors was observed among MSM. Twenty-eight out of forty-one MSM study subjects (68.0%) infected were implicated in five transmission clusters, two of which are subtype A1 and three subtype B strains. The two largest MSM subtype B clusters included nine and eight Cypriot men, respectively, living in all major cities in Cyprus. There were only three newly diagnosed patients with transmitted drug resistant HIV-1 strains, one study subject from the United Kingdom infected with subtype B strain and one from Romania with subtype A2 strain, both with the PI drug resistance mutation M46L and one patient from Greece with subtype A1 strain with the NNRTI drug resistance mutation K103N. Disclosures All authors: No reported disclosures.

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