scholarly journals Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus

2010 ◽  
Vol 120 (8) ◽  
pp. 2858-2866 ◽  
Author(s):  
Federica Di Nicolantonio ◽  
Sabrina Arena ◽  
Josep Tabernero ◽  
Stefano Grosso ◽  
Francesca Molinari ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Signaling Pathways ◽  
Human Cancer ◽  
Human Cancer Cells

scholarly journals DOX-Vit D, a Novel Doxorubicin Delivery Approach, Inhibits Human Osteosarcoma Cell Proliferation by Inducing Apoptosis While Inhibiting Akt and mTOR Signaling Pathways

Pharmaceutics ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 144 ◽  
Author(s):  
Zaid Maayah ◽  
Ti Zhang ◽  
Marcus Forrest ◽  
Samaa Alrushaid ◽  
Michael Doschak ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cancer Cells ◽  
Signaling Pathways ◽  
Human Cancer ◽  
Death Receptor ◽  
Osteosarcoma Cell ◽  
Acquired Drug Resistance ◽  
Human Cancer Cells ◽  
Mg63 Cells ◽  
Delivery Approach

Doxorubicin (DOX) is a very potent and effective anticancer agent. However, the effectiveness of DOX in osteosarcoma is usually limited by the acquired drug resistance. Recently, Vitamin D (Vit-D) was shown to suppress the growth of many human cancer cells. Taken together, we synthesized DOX-Vit D by conjugating Vit-D to DOX in order to increase the delivery of DOX into cancer cells and mitigate the chemoresistance associated with DOX. For this purpose, MG63 cells were treated with 10 µM DOX or DOX-Vit D for 24 h. Thereafter, MTT, real-time PCR and western blot analysis were used to determine cell proliferation, genes and proteins expression, respectively. Our results showed that DOX-Vit D, but not DOX, significantly elicited an apoptotic signal in MG63 cells as evidenced by induction of death receptor, Caspase-3 and BCLxs genes. Mechanistically, the DOX-Vit D-induced apoptogens were credited to the activation of p-JNK and p-p38 signaling pathway and the inhibition of proliferative proteins, p-Akt and p-mTOR. Our findings propose that DOX-Vit D suppressed the growth of MG63 cells by inducing apoptosis while inhibiting cell survival and proliferative signaling pathways. DOX-Vit D may serve as a novel drug delivery approach to potentiate the delivery of DOX into cancer cells.

Indirubin derivatives inhibit SFKs/Stat signaling associated with apoptosis in human cancer cells

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
S Nam ◽  
R Buettner ◽  
X Liu ◽  
J Turkson ◽  
D Kim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Stat Signaling

Antiproliferation Effects of Germinated-Korean Rough Rice Extract on Human Cancer Cells

2010 ◽  
Vol 39 (3) ◽  
pp. 325-330 ◽  
Author(s):  
Hyun-Young Kim ◽  
In-Guk Hwang ◽  
Eun-Mi Joung ◽  
Tae-Myoung Kim ◽  
Dae-Joong Kim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Rough Rice
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