scholarly journals Nurse-like cells from bone marrow and synovium of patients with rheumatoid arthritis promote survival and enhance function of human B cells.

1998 ◽  
Vol 102 (3) ◽  
pp. 606-618 ◽  
Author(s):  
Y Shimaoka ◽  
J F Attrep ◽  
T Hirano ◽  
K Ishihara ◽  
R Suzuki ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Marrow ◽  
B Cells ◽  
Human B Cells

scholarly journals B cells suppress medullary granulopoiesis by an extracellular glycosylation-dependent mechanism

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Eric E Irons ◽  
Melissa M Lee-Sundlov ◽  
Yuqi Zhu ◽  
Sriram Neelamegham ◽  
Karin M Hoffmeister ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
B Cells ◽  
Progenitor Cell ◽  
Hematopoietic Progenitors ◽  
Myeloma Cells ◽  
Human B Cells ◽  
Extrinsic Cues ◽  
Bone Marrow Niches ◽  
Dependent Mechanism

The immune response relies on the integration of cell-intrinsic processes with cell-extrinsic cues. During infection, B cells vacate the marrow during emergency granulopoiesis but return upon restoration of homeostasis. Here we report a novel glycosylation-mediated crosstalk between marrow B cells and hematopoietic progenitors. Human B cells secrete active ST6GAL1 sialyltransferase that remodels progenitor cell surface glycans to suppress granulopoiesis. In mouse models, ST6GAL1 from B cells alters the sialylation profile of bone marrow populations, and mature IgD+ B cells were enriched in sialylated bone marrow niches. In clinical multiple myeloma, ST6GAL1 abundance in the multiple myeloma cells negatively correlated with neutrophil abundance. These observations highlight not only the ability of medullary B cells to influence blood cell production, but also the disruption to normal granulopoiesis by excessive ST6GAL1 in malignancy.

Mesenchymal stem cells from bone marrow of rheumatoid arthritis patients provide survival signals to T- and B- cells in vitro

2007 ◽  
Vol 74 (2) ◽  
pp. S217 ◽  
Author(s):  
Tomas Dallos ◽  
Monika Krivosikova ◽  
Lukasz Luszczyna ◽  
Magdalena Chorazy-Massalska ◽  
Ewa Warnawin ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
B Cells ◽  
T And B Cells ◽  
Survival Signals

scholarly journals Functional TLR9 modulates bone marrow B cells from rheumatoid arthritis patients

2009 ◽  
Vol 39 (5) ◽  
pp. 1211-1220 ◽  
Author(s):  
Weronika Rudnicka ◽  
Tomasz Burakowski ◽  
Ewa Warnawin ◽  
Magdalena Jastrzebska ◽  
Magdalena Bik ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Marrow ◽  
B Cells

scholarly journals A Refined Protocol for Identifying Citrulline-specific Monoclonal Antibodies from Single Human B Cells from Rheumatoid Arthritis Patient Material

BIO-PROTOCOL ◽  
2019 ◽  
Vol 9 (17) ◽  
Author(s):  
khaled Amara ◽  
Lena Israelsson ◽  
Ragnhild Stålesen ◽  
Peter Sahlström ◽  
Johanna Steen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Monoclonal Antibodies ◽  
Rheumatoid Arthritis Patient ◽  
B Cells ◽  
Human B Cells

Human Bone Marrow Mesenchymal Stem Cells Support Polyclonal Stimulation of Human B Cells

2007 ◽  
Vol 123 ◽  
pp. S119
Author(s):  
Elisabetta Traggiai ◽  
Alberto Martini ◽  
Antonio Uccelli ◽  
Lorenzo Moretta ◽  
Federica Benvenuto ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
B Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Human B Cells ◽  
Marrow Mesenchymal Stem Cells ◽  
Stimulation Of

scholarly journals B cells suppress medullary granulopoiesis by an extracellular glycosylation-dependent mechanism

2019 ◽  
Author(s):  
Eric E. Irons ◽  
Melissa M. Lee-Sundlov ◽  
Karin M. Hoffmeister ◽  
Joseph T.Y. Lau
Keyword(s):  
Bone Marrow ◽  
B Cells ◽  
Elevated Blood ◽  
Hematopoietic Progenitors ◽  
Myeloma Cells ◽  
Human B Cells ◽  
Extrinsic Cues ◽  
Bone Marrow Niches ◽  
Dependent Mechanism ◽  
Dependent Interaction

AbstractThe immune response relies on the timely integration of cell-intrinsic processes with cell-extrinsic cues. During infection, B cells vacate the bone marrow for the emergency generation of granulocytes. However, it is unclear if cross-talk between B cells and neutrophils also encourages the return to homeostasis. Here, we report that B cells remodel glycans on hematopoietic progenitors to suppress granulopoiesis. Human B cells secrete active ST6Gal-1 sialyltransferase to modify the sialylation and Gr-1 expression of co-cultured hematopoietic progenitors. After adoptive transfer, total hematopoietic and B cells modified the sialylation of non-self cells and elevated blood ST6Gal-1. Mature IgD+ B cells co-localized with megakaryocytes to sialylated bone marrow niches, suggesting their role in medullary extrinsic sialylation. Finally, ST6Gal-1 expression in multiple myeloma cells negatively correlated with neutrophil abundance in human patients. Our results highlight the growing significance of extracellular glycoslytransferases as mediators of a novel glycan-dependent interaction between B cells and granulocytes.

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